DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and evi5b

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_009300706.2	Gene:	evi5b / 553306	ZFINID:	ZDB-GENE-041111-244	Length:	837	Species:	Danio rerio

Alignment Length:	772	Identity:	350/772 - (45%)
Similarity:	508/772 - (65%)	Gaps:	58/772 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDT 70
            ||.|||.   |.:.....|.|.:  |...:::||||||..|:|:|:|:|||.|::.  ||:||.:
Zfish    41 TTVASST---ASLSSPSSASPTQ--LSPDDVELLAKLEEQNRLLETDSKSLRSVNG--SRRNSGS 98

  Fly    71 SQISLTSSGNSVA--EEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGAS 133
            |.:|.:|:.::::  |||.|..|..|:|:||...|:|...:.||||:|:||||||||||.|..|.
Zfish    99 SLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQLKELVRKGVPHHFRAIVWQLLCNAQ 163

  Fly   134 D-GDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQ 197
            : ..|:||:|.:|.||.|||:|||||||||||.|||||||..|||.||||:|||||.||||||||
Zfish   164 NLPIKEQYSELLKMTSPCEKLIRRDIARTYPEHEFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQ 228

  Fly   198 GSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQ 262
            ||.||||||||||||||||.|.|::||::|:|.:|||||:||||||||.|.::|||:|::|:|||
Zfish   229 GSAFIVGLLLMQMPEEEAFCVFVKLMQEYRLRELFKPSMAELGLCMYQFECMIQEQLPELHVHFQ 293

  Fly   263 QQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAM 327
            .|.|.|:|||||||||::.|:..:.::.||.|:|:.||:|.:|:|.:|:|...:..|:.||||.|
Zfish   294 AQSFHTSMYASSWFLTIFLTSFPLPVATRIFDIFMCEGLEIVFRVGMAILQMNQAELMQLDMEGM 358

  Fly   328 LKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLK 392
            |:.|||.:|.::::..:.....||.:|.|.|:|||:||||..:|.||.||..|::|||.||.|||
Zfish   359 LQHFQKVIPHQLDSGPDKVIQAAYQVKYNAKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLK 423

  Fly   393 QRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLR 457
            ||.:.||.|||.|||||::|||:||:|.|.:|.::.||..:::...|.|.|||.|...:|    :
Zfish   424 QRIDTLEKESASLADRLIQGQVTRAQEAEENYLVKRELATVKQHIEETSVQLEQAQSTIR----Q 484

  Fly   458 LQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEE 522
            ||:   .....|.|.:        ||::.|       |..|||:.|...|||:..::.::.|:.:
Zfish   485 LQQ---PFAKGNPRYT--------EESILQ-------LERELVQARLKEAESQCALKEMQDKILD 531

  Fly   523 LEEDKKTLRETTPD-NSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAENQRSES 586
            :|:...:|    || |:|..||:|||..|||||||...||:|:|:|::|...|||.||
Zfish   532 MEQRNTSL----PDENNVVRLQEELIGVKLREAEALTGLKELRQQVRDLEEHWQRHLA------- 585

  Fly   587 ERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREMETLTELKELRLKVMELETQVQV 651
             ||......:|:|        :.:||    |::|||:.|:||.|...||:|.|.:::|||||.|:
Zfish   586 -RTAGRWKDSPRK--------NAASE----LQDELMSVRLREAEAQAELRETRQRMLELETQNQI 637

  Fly   652 STNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLESRMKDELMNVKIKFTEQSQTV 716
            .:|||||.:.|.:.|::.|.:...:.|.:.::.:|.:.:.:::|.:.|:|:|.|:::..:....:
Zfish   638 HSNQLRRAELEARNLQDRLHVLSNQNKMLHSELQETKRKQAEIECKNKEEVMAVRLREADNIAAM 702

  Fly   717 AELKQEISRLETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSRGKFP 773
            |||:|:||.||.:..|...:|:|. |.|.|..:|||:|::||:|.|:..|:.....|
Zfish   703 AELQQQISELEIQKEEGKVQGQLN-NTDSSQYIRDLKDQIADLKHEIRCLRGHQGLP 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	133/207 (64%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	36/103 (35%)
evi5b	XP_009300706.2	TBC	143..351	CDD:214540	133/207 (64%)
evi5b	XP_009300706.2	SMC_N	<389..718	CDD:330553	143/374 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121902
Inparanoid	1	1.050	579	1.000	Inparanoid score	I998
OMA	1	1.010	-	-		QHG46583
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm25791
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	1	1.000	-	-		X1412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010