DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and CG42795

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001287272.1	Gene:	CG42795 / 41252	FlyBaseID:	FBgn0261928	Length:	3213	Species:	Drosophila melanogaster

Alignment Length:	1064	Identity:	209/1064 - (19%)
Similarity:	359/1064 - (33%)	Gaps:	348/1064 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DLLAKLEAANKLIESD--------------AKSLNSLHSTHSRKNSDTSQISLTSSG-NSVAEED 86
            ::|.:...|..::|||              .|::.|...|...|||.:|..::|:.| |:.:...
  Fly   101 EVLCEFVTAVLIVESDDAQPKMRFSLSPPPQKAITSARLTSPTKNSLSSNNTITTPGSNNRSPSS 165

  Fly    87 IWTTWAT-------------------------------ILNDWEGALKRKNPCVSELVRR---GI 117
            ..||..|                               ..|.|..|:|        ||.|   |.
  Fly   166 TKTTMLTRNGGGHGTSPTASGSGHAPSATAAADDEATSDYNQWLHAMK--------LVARLPGGT 222

  Fly   118 PHHFRAIVWQQLSGASDGDKKQYAEYIKATSA----------CEK----------VIRRDIARTY 162
            |..||..:|..|:     ||     |:|:.:.          ||:          .|.:|:.||.
  Fly   223 PPEFRRKLWLSLA-----DK-----YLKSKNVDWAQQREKCFCEEWREDDEELGIQIVKDLHRTG 277

  Fly   163 PEVEFFKEKDGP----GQEALFNVIKAYSLHDREVGYCQGSGFIVGLLL--MQMPEEEAFAVLVQ 221
            ..:     ..||    .|..|..::..|:.::.|||||||...:..|:|  |...|||:..|::.
  Fly   278 SNL-----CTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIY 337

  Fly   222 IMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQ-QG-----FQ---TTMYASSWFL 277
            :::.......|..||..|...|.....|:|.::|.:..|.|: ||     |:   |.::...|||
  Fly   338 LVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFL 402

  Fly   278 TLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCL----DMEAMLKFFQKELPGR 338
            |::.|.|.::...|:.|:.|.||.:.:.:.||.|....::.::.:    :....:..:..||...
  Fly   403 TMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGKMGSYSSELLNG 467

  Fly   339 VEADVEGFFNLAYSIKLNTKRMKKME--KEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAE 401
            ...|..|..          :|:.|:.  ::.:.|:.|....:|.||  .::...|....|...::
  Fly   468 HLVDSNGLI----------ERVVKLGPIEDLRQLRDKHLYNIAPLR--HKQGLQLYYDEEDTHSD 520

  Fly   402 SAELADRLV-------RGQVSRA----EEEETSYAIQTELMQLRRSYLEVSHQLENA-------- 447
            ...||...|       ||.|..|    ::.|....:..::..|::.|..:..:.:.|
  Fly   521 EERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQKQAHVILTTAC 585

  Fly   448 --------------------NEEVRG--------------------------------------L 454
                                |:.:.|                                      .
  Fly   586 STAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVLHTKPTSEK 650

  Fly   455 SLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNL--- 516
            .||..|..:..|::.||:.. |.|..||  :|         .:....:|:|:..|..:.:.|
  Fly   651 QLRRGETLLWRDTDPSRRRR-DSLTWKE--IK---------ADRAAMIREGVDVSSVRTQKLRTR 703

  Fly   517 --KAKVEELEEDKKTLRE--------TTPDNSVAHLQDELIASKLREAEASLS--LKDLKQRVQE 569
              |:......||....:|        ::.|.|:....|.....|..:.:|.|:  ||:.||....
  Fly   704 FGKSDSSSYSEDSDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQLAGS 768

  Fly   570 LSSQWQRQ--------------------------------------LAENQRSES-----ERTTN 591
            ..:..:||                                      .||:..:||     :|..:
  Fly   769 RETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGDQAEDSATESGHYEFDRELH 833

  Fly   592 AVDSTPKKLLTNF---FDSSKS------SEHTQKLEEELMT-----------------TRIREME 630
            .|.|..:.|...|   |....|      .....:.||:|:.                 .|:..:|
  Fly   834 LVSSKMEPLKLPFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPFDVSDDGVTNQYFERVNSVE 898

  Fly   631 TLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKE--ELEMAVTREKD--MSNKAREQQHRY 691
            ....| ||...:.|.||.......:.|.:.|.|...:|  .|.....||.|  :....:..|.|.
  Fly   899 RPNRL-ELTYSLNEEETDTNAIYLEEREKVEGHSGDREYNSLPPFYPRENDDGVQGGGKVPQIRD 962

  Fly   692 SDLESRMKD---ELMNVKI----------------------------KFTEQSQTVAELKQEISR 725
            .::....||   ||:::.|                            |...:|.|: |:::....
  Fly   963 DNIPGENKDDYKELLSMTIEENTVYKPPTPTASTLSNASRKRRDPRRKTLTRSSTI-EIEERYQA 1026

  Fly   726 LETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSR-------GKFPGAKLRSSSIQ 783
            ||.:.|:....|:.:|....|...  |::|...::.:|:|.|.|       .::|   ::|..|.
  Fly  1027 LERRISQDQPSGDRQAKYIPSTAA--LEERFNTLEKQLSAEKQRKELSEMEAEYP---IKSERIP 1086

  Fly   784 SIESTEIDFNDLNMVRRGSTELST 807
            |....|..||.|.. :..|:|.|:
  Fly  1087 STADLESRFNSLTK-QMSSSESSS 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	65/244 (27%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	28/138 (20%)
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:278964	51/179 (28%)
		DUF4682	560..684	CDD:292361	16/135 (12%)
		DBP	1112..1415	CDD:289157
		SWIRM-assoc_2	<2376..2482	CDD:293105
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840