Protein Alignment Evi5 and plx

DIOPT Version :9

• Sequence 1: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 156/644 - (24%)
• Similarity: 275/644 - (42%)
• Gaps: 115/644 - (17%)

  Fly    28 EENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTH-------SRKNSDTSQISLTSSGNSVAE- 84
            :..:||   :.|:.:....|..:.||..|..|..|.       :|..::.:.:....:.|.:..
  Fly   830 DSEVPT---EFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRI 891

  Fly    85 ----EDIWTTWATILNDWEGALKR--------KNPCV-SELVRRGIPHHFRAIVW-----QQLSG 131
                |:|......::..||..::|        |:|.| ...:|.|:|...|..||     |....
  Fly   892 KLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMN 956

  Fly   132 ASDGDKKQYAEY-------IKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLH 189
            .:..|.|::..:       :|..:..:..|..|:.||:|..:|:|:..|.||.:|||::||||:.
  Fly   957 TAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSIL 1021

  Fly   190 DREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQI 254
            |.|:|||||.|||.|:||:...|..:|.:|..:|.:..||..:.|.|.:..|.:|||..||::.:
  Fly  1022 DPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHL 1086

  Fly   255 PDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTL 319
            ||:::...|.....|:||:.|.||::::...:....|:.|:...|..:.|||.|:|||...|..|
  Fly  1087 PDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQL 1151

  Fly   320 LCLD-MEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRR 383
            |..| .|.::.:.:..:|......:|....|.:|:.:. |::.:.:.||..|:::.......|..
  Fly  1152 LAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIG-KQLAEYKVEYNVLQEEITTTNHHLEM 1215

  Fly   384 LRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENAN 448
            |.||    |.:|:.|                    |::..:| |:.:.||..:......|:....
  Fly  1216 LNRE----KTQNQHL--------------------EQQLQFA-QSSIAQLETTRSSQQAQITTLQ 1255

  Fly   449 EEVRGLSLRLQ----------ENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVR 503
            .:|:.|.|.:|          |:|..::..|..:..:.:                  |::|.:.|
  Fly  1256 SQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQ------------------LDDLDRQR 1302

  Fly   504 QGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQ 568
            :....:|.:|....:....|....|.|.|.|.       :|||.:.:.::.|.:...:.|:|:
  Fly  1303 RKPIFTERKIGKSVSVNSHLGFPLKVLEELTE-------RDELGSPQKQKKEKTPFFEQLRQQ-- 1358

  Fly   569 ELSSQWQRQLAENQRSES--ERTTNAVDSTPKKLLTNF---------FDSSKSSEHTQK 616
                |.|.:|....:|.:  |..:....|.|.:||.|.         .|..|..||..|
  Fly  1359 ----QQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDK 1413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	74/218 (34%)
		DUF4527	627..>731	CDD:291689
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	9/47 (19%)
		TBC	933..1152	CDD:214540	74/218 (34%)
		RILP-like	<1176..1267	CDD:304877	23/116 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456556
Domainoid	1	1.000	109	1.000	Domainoid score	I1618
eggNOG	1	0.900	-	-		E1_KOG4436
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.870