DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and CG7324

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_649305.1	Gene:	CG7324 / 40361	FlyBaseID:	FBgn0037074	Length:	1291	Species:	Drosophila melanogaster

Alignment Length:	885	Identity:	202/885 - (22%)
Similarity:	343/885 - (38%)	Gaps:	180/885 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNS--DTSQISLTSSGNSV--------- 82
            ||:|.    :.|.:.....||......|..:|...||:.:  |.|....|:..|:.
  Fly   366 ENVPF----MFAHIVDRAVLISKITDLLARVHVPLSRERAKYDISWSKQTALMNTFKTQFSAEII 426

  Fly    83 -AEEDIWTTWATILNDW-EGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASDGDKKQ----YA 141
             .:|:....|.....|: .|....:...|..|:..|||...|..:|...|||.. ||:.    |.
  Fly   427 QKQEEKMVRWEAHFRDFGRGIGMFRTTDVINLIVEGIPDKLRQEIWLIFSGAIH-DKEMNPGLYE 490

  Fly   142 EYIKATSACEK------VIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSG 200
            :.:: .:||.|      .|.||:.|:.||...|:..||.|  ||..|::||:|.:.:|||||...
  Fly   491 DLVE-KAACIKNCFAHDEIDRDLPRSLPEHPAFQSTDGIG--ALRRVLQAYALRNPQVGYCQAMN 552

  Fly   201 FIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQG 265
            .:..:.|:...||.||.:|..:. ::.:...:|..:....:....|..||:..:||:|.|.:|.|
  Fly   553 IVSSVFLLFCDEENAFWMLASLC-ENLLPDYYKDKVVGAQIDQGVLNELVETHLPDLHGHLEQLG 616

  Fly   266 FQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCL--DMEAML 328
            . ..|.:.|||||::.:.::...|..|:|.|..||.:.||.::|.::...:|.||..  |.||||
  Fly   617 V-IKMISISWFLTIFMSVISYESSLHILDCFFYEGAKIIFMISLQIIEWNRDKLLICQDDGEAML 680

  Fly   329 KFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQ---------DLKKKEQEEMAELR-- 382
            .         ::..:||.:|..|.:...|.: :|||::.|         :...|..|::.:.|
  Fly   681 V---------LQNYLEGVYNPEYQVPPTTDK-RKMERKVQTQTVQTLIHEAYTKFGEDITQQRIE 735

  Fly   383 RLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENA 447
            .||.::..|..|...::.|..     :|:..|      :..|..::||..|.....|..|.|::.
  Fly   736 ELRNKHRRLTMRQFDIDNEKT-----IVKAYV------QNPYFNRSELHMLLTIIREEKHALKSL 789

  Fly   448 NEEVRGLSLRLQENNVSIDSNNSRQSSIDELCM---KEEALKQRDEMVSCLLEELVKVRQGLAES 509
            .::.:.:...|.|....:..:.||  .|.:...   :.||.....|:...|..||...|
  Fly   790 QQQQQKVQCPLSETPQLVPQSTSR--PIQDAGASGGRYEAYSVSYEVFHTLFTELTPWR------ 846

  Fly   510 EDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQD--ELIASKLREAEASLSLKDLKQRVQELSS 572
                     |...::..:|..|.|  |.....:.|  :||        .:|.|....:.:::|..
  Fly   847 ---------KCVSVDIGEKLFRLT--DKKGTGVLDFGQLI--------NALGLVCSNKNMEKLKL 892

  Fly   573 QWQRQL------AENQRSESERTTNAVDSTPKKLLTNFFDSSKS---------SEHTQKLEEELM 622
            .:...|      ||.:||...|.....|:.......:|||:..|         |:|....::..:
  Fly   893 LYVLHLPPLLSKAEIERSRRPRPRTKDDAEEAFEAEDFFDNDASESMEALPSPSDHNFDADDFAL 957

  Fly   623 TTRIREMETLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELEMA----------VTRE 677
            .:..:.:..|..:.....  |:|.....:|.|. ......|:.....:::.          ..|:
  Fly   958 ISATQHLHNLAGISGNTF--MDLSRTPNLSVNS-NTSSLAHRSSTFYVDLPGFQGTATSTDAGRD 1019

  Fly   678 KDMSNKAREQQHRY---------SDL---------------------ESRMKDE-LMNVKI--KF 709
            :|...:...||.||         |||                     .|...|. |:||:.  .|
  Fly  1020 EDELQRQLRQQGRYESIDTFSDISDLGAARITPPEAGVGADVVAGAASSAAADHMLLNVETISNF 1084

  Fly   710 TEQSQTVAELKQEISRLETKNSEMLAEGELRANLDDSDK-VRDLQDRLADMKAELTALKSRG--K 771
            ::.|..||..:.|  |:::..:::.:.|.|...||..|: ..:.|..:..|:.|...|..|.  :
  Fly  1085 SQISDLVAATRLE--RVDSNATDLRSLGSLGYLLDQPDEGASNSQHSIPHMRKENFQLLWRSIIE 1147

  Fly   772 FPG--------------AKLRSSSIQSIESTEIDFNDLNM 797
            ..|              .:|.:|:|:...|.| .|..|||
  Fly  1148 IMGLVQDEEMQRAYENLLELGNSNIKKEPSLE-SFTQLNM 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	67/216 (31%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	26/146 (18%)
CG7324	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	6/26 (23%)
		TBC	462..670	CDD:214540	67/213 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940