DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and CG8155

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_611029.3	Gene:	CG8155 / 36698	FlyBaseID:	FBgn0034009	Length:	1098	Species:	Drosophila melanogaster

Alignment Length:	1016	Identity:	205/1016 - (20%)
Similarity:	340/1016 - (33%)	Gaps:	296/1016 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TTASSAESQAK--MDVKGGALPGEEN--LPTSE-MDLLAKLEAANKLIESDAKSLNSLHSTHSRK 66
            |.....|::|.  ..:.|...|....  :|..| |..|..|..:.|.::.....|.|     |..
  Fly   108 TVVRECETEASPGRSITGAPAPATPAPFVPARELMSPLQSLGVSQKYVQHMQTKLGS-----SIL 167

  Fly    67 NSDTSQISLTSSGNSVAEE---------DIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFR 122
            |......|:.....:::||         .:..:...:..|..|.::||:.....:...||....|
  Fly   168 NQMEKTFSIVQKAFNLSEEHMANLPPRPPMCDSEFRLFLDALGQIQRKDELHRVIFLGGIDPSLR 232

  Fly   123 AIVWQQL----SGASDG---DKKQYAEYI--KATSACE----------------------KVIRR 156
            .:||:.|    .|.::|   |..|..|::  |:...|.                      .::::
  Fly   233 RVVWKHLLNVYPGGANGLALDGHQRMEFMRRKSEQYCRLRDTWKAAVKRGSVAGELAYVTSMVKK 297

  Fly   157 DIARTYPEVEFFK-EKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEE-EAFAVL 219
            |:.||.....|:. ..|.....||||::..|:|:...|.||||...|...||:.|.:| :|:...
  Fly   298 DVLRTDRLHPFYAGSDDNQNIAALFNILTTYALNHPSVSYCQGMSDIASPLLVTMNDEAQAYICF 362

  Fly   220 VQIMQQHRMRHMFKPSMSELGLCMYQ----LENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLY 280
            ..||.:.|...|..      |:.|.|    |...:....|:...:.:.|.....::...|.|
  Fly   363 CAIMSRMRGNFMLD------GIAMTQKFAHLTEALSFYDPEFWEYLKSQQADDLLFCYRWLL--- 418

  Fly   281 TTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTL--LCLDMEAMLKFFQKELPGRVEADV 343
                            |....||.|:.||.:|.....:|  .| |.|..|..|:||.....:|.|
  Fly   419 ----------------LELKREFPFEDALRMLEVQWSSLRYRC-DGEKELALFEKEFVPITDASV 466

  Fly   344 ---EGFFNLAYS------------------IKL--------------------------NTKRMK 361
               ...|:.:||                  .|:                          ||||:.
  Fly   467 PNSASTFSSSYSATPTSPSYLLTKPRESPYTKVCALRRQSSSASLSSLSSSVGTSHGLDNTKRLN 531

  Fly   362 -----KMEKEYQDLKKKEQEEMAELRRLRRENCL-------LKQRNELL--------EAESAELA 406
                 .|.:......::::...|::.:...|:.:       |..||..|        |.|..::.
  Fly   532 HSLDDNMSRHATAAARRQRRTSAKVHQSLDESKMLALIEGALDNRNVKLEQNLSAGEETEDDDVF 596

  Fly   407 DRL----------VRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLRLQEN 461
            ||.          .:....||.|.||     |..:...|::| .|....|.:|:......:||..
  Fly   597 DRKESPSFLETNPFKDDAQRAPERET-----TPPVSPGRAFL-CSSSSSNLDEDPSDRKAKLQHK 655

  Fly   462 NVSIDSNNSRQSSIDELCMKEEALKQ---------RDEMVSCLLEEL-VKVRQGLA---ESEDQ- 512
            |:...||...:..........|::|:         :|     |.|:| ...|.|::   |.||.
  Fly   656 NIMTVSNIIAKQLATNASQVSESMKRVSTSSGGHFKD-----LKEKLAASSRIGISFDGEGEDDG 715

  Fly   513 --------IRNLKAKVEELEEDKKTLRE---TTPDNS---------VAHLQDELIASKLREAEAS 557
                    ::|....:.....:|..:.:   |.|..:         |..|....:.|.|.|:::|
  Fly   716 DRKMPPKLVKNFNEFLNFATINKNRISDRFATQPQQTSGPISVTKPVVQLTKSGMGSSLDESDSS 780

  Fly   558 LSLKDLK----------QRVQELSS-QWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSKSS 611
             ||.:..          |:.||||| ..|..|..|...:.: .:|..|..|.:
  Fly   781 -SLPETSWSASTAATTIQQAQELSSYNLQLDLESNHPCDPD-DSNTPDQDPDQ------------ 831

  Fly   612 EHTQKLEEELMTTRIREMETLTELKELRLKVMELETQV--QVSTNQLRRQDEEHKKL-KEELEMA 673
                  |...|||.|        .:||||:...|:.||  ...|...:|:|.|::|| |:.|::.
  Fly   832 ------EYYPMTTAI--------TRELRLEAENLDRQVFGLPFTESEKREDIEYEKLDKDALDLV 882

  Fly   674 VTREK-------DMSNKAREQQHRYSDLESRMKDELMNVKIKFTEQSQTVAELKQEISRLETKNS 731
            ...::       |:|.....::.|.:...:.::....:....|.::||    |....|.|..:||
  Fly   883 EDLKENEIITCPDVSELHMRRRQRLAAKSNSVQQNESHAFNPFIDESQ----LMDGHSPLGMRNS 943

  Fly   732 EMLAE-----------------GELRANLDDSDKVRDLQDR------LADMKAELTALKSRGKFP 773
            ..|.|                 .|:..|.||.........|      ::.:.....||....:|.
  Fly   944 NSLPEVILPISTEPSLVEVSPLVEIATNADDESAYTRSPQRSTHLNGVSAVNTTAAALPPPTEFG 1008

  Fly   774 GAK---------LRSSSIQSIESTEIDFNDL-----NMVRR 800
            |..         |......:|....:|:|::     .|||:
  Fly  1009 GGNAFLMFLCLTLLLQHRNTIMKAGMDYNEIAMHFDKMVRK 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	55/245 (22%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	24/113 (21%)
CG8155	NP_611029.3	TBC	225..439	CDD:214540	54/238 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940