Protein Alignment Evi5 and tbc1d4

DIOPT Version :10

• Sequence 1: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_002663441.2
• Gene: tbc1d4 / 321065
• ZFINID: ZDB-GENE-030131-9881
• Length: 1246
• Species: Danio rerio
• Alignment Length: 584
• Identity: 140/584 - (23%)
• Similarity: 252/584 - (43%)
• Gaps: 138/584 - (23%)

  Fly    12 AESQAKMDVKGGALP-----GEENLPTS----------EMDLLAKLEAANKLIESDAKSLNSLHS 61
            |.:|.:.|..|...|     |::..|..          :..||.::|..|:.:|:....|
Zfish   759 ALTQDQGDQTGPQSPEQSSAGQKRSPADYRGLWKKAIHQQILLIRMEKENQRLEASRDEL----- 818

  Fly    62 THSRK-NSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPC----------VSELVRR 115
             |.|| ..|..::...|       :::...|..         |..:||          :...|.:
Zfish   819 -HIRKMKLDYQEVCSCS-------KELQALWDR---------KLSSPCRTKVQWNKEEIHSAVCQ 866

  Fly   116 GIPHHFRAIVW----------QQLSGASDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKE 170
            |:|...|..||          |:|.......:..:.:.:|..:|.:..|..|:.||:|..::|..
Zfish   867 GVPKSRRGEVWLLLSQQHRLRQRLPHRQQPPETPFQDLLKQLTAQQHAILVDLGRTFPTHQYFSA 931

  Fly   171 KDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPS 235
            :.|.||.:|:|::|||||.|.|||||||..|:.||||:.|.||::|..|..:|....:|..::|.
Zfish   932 QLGAGQLSLYNLLKAYSLLDTEVGYCQGISFVAGLLLLHMSEEQSFDTLKFLMYDLGIRRQYRPD 996

  Fly   236 MSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEG 300
            |..|.:.||||..|:.:...:::.|..:.....::||:.|||||:.:...:....||.|:...:|
Zfish   997 MISLQIQMYQLSRLLHDYHRNLYSHLDEHEICPSLYAAPWFLTLFASQFPLGFVARIFDLLFVQG 1061

  Fly   301 MEFIFKVALALLLTGKDTLL-CLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKME 364
            .|.||||||.||.:.:..:| |...|:::.:.:..:|....:.:|.....|..:.: :|:::..|
Zfish  1062 TEVIFKVALCLLSSHEGEILECDSFESIVDYLKSTIPTLTHSQMEEIITKAIEMDI-SKQLQAYE 1125

  Fly   365 KEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTE 429
            .||..|    |:|:::...|                  :|.:|||     .:.|:..|
Zfish  1126 VEYHVL----QDELSDAPPL------------------SEDSDRL-----DKLEKANT------- 1156

  Fly   430 LMQLRRSYLEVSHQLENANEEVRGLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSC 494
              |||:..:::..:|:.|.       |::|....|::|..||:|.:..|
Zfish  1157 --QLRKQNMDLLEKLQAAR-------LKIQTLESSVESFLSRESKMKHL---------------- 1196

  Fly   495 LLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQ-DELIASKLREAEAS 557
                              ||:|:.:....::..:.:|.:.|.::.|.:: .:|.:|...:|:|:
Zfish  1197 ------------------IRSLEQEKASYQKTIERMRNSLPSDTTAEVEMTQLKSSTNGKAKAA 1242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	75/216 (35%)
		Smc	<358..>761	CDD:440809	37/201 (18%)
tbc1d4	XP_002663441.2	PTB	16..159	CDD:214675
		PTB_TBC1D1_like	161..415	CDD:269967
		DUF3350	751..812	CDD:463365	11/52 (21%)
		TBC	866..1081	CDD:214540	74/214 (35%)
		HEC1	<1085..1241	CDD:444066	40/233 (17%)