DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and Tbc1d4

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_038949896.1	Gene:	Tbc1d4 / 306117	RGDID:	1561609	Length:	1300	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	138/545 - (25%)
Similarity:	237/545 - (43%)	Gaps:	131/545 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGAL 102
            ||.::|..|:.:|:....|      .|||      :.|.       .|::.|....:|..|:..|
  Rat   854 LLLRMEKENQKLEARRDEL------QSRK------VKLD-------YEEVGTCQKEVLIAWDKKL 899

  Fly   103 ---KRKNPC----VSELVRRGIPHHFRAIVWQ----------QLSGASDGDKKQYAEYIKATSAC 150
               :.|..|    :...::.|:|...|..:||          :|..........|.|.:|..:|.
  Rat   900 LNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQ 964

  Fly   151 EKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEA 215
            :..|..|:.||:|...:|..:.|.||.:|||::|||||.|:|||||||..|:.|:||:.|.||:|
  Rat   965 QHAILVDLGRTFPTQPYFSVQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQA 1029

  Fly   216 FAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLY 280
            |.:|..:|.....|..::|.|..|.:.||||..|:.:...|::.|.::.....::||:.|||||:
  Rat  1030 FEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLF 1094

  Fly   281 TTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLL--CLDMEAMLKFFQKELPGRVEADV 343
            .:...:....|:.|:...:|.|.||||||: ||:.::.|:  |.:.|.:::|.:..||.....::
  Rat  1095 ASQFPLGFVARVFDIIFLQGTEVIFKVALS-LLSSQEALVMECENFENIVEFLKSTLPDMNTTEM 1158

  Fly   344 EGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADR 408
            |......:.:.: :|::...|.||..|                       ::||||:..|
  Rat  1159 EKIITQVFEMDI-SKQLHAYEVEYHVL-----------------------QDELLESSYA----- 1194

  Fly   409 LVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLRLQENNVSIDSNNSRQS 473
                    .|:.|:...::....||:|..:::..:|:.|:.:::.|                 :|
  Rat  1195 --------CEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQAL-----------------ES 1234

  Fly   474 SIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNS 538
            :::.|..:|                               ..:||.:..||:||...::|
  Rat  1235 NLETLLTRE-------------------------------TKMKALIRTLEQDKMAYQKT----- 1263

  Fly   539 VAHLQDELIASKLREAEASLSLKDL 563
            |..::..|.|..|  |...|.||||
  Rat  1264 VEQIRKLLPADAL--ANCELLLKDL 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	76/216 (35%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
Tbc1d4	XP_038949896.1	PTB	31..190	CDD:214675
		PTB_TBC1D1_like	193..446	CDD:269967
		DUF3350	803..866	CDD:403130	4/11 (36%)
		TBC	920..1130	CDD:214540	76/210 (36%)
		PTZ00440	<1134..>1265	CDD:240419	34/220 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910