DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and Evi5l

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_038945835.1	Gene:	Evi5l / 304201	RGDID:	1561962	Length:	815	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	332/780 - (42%)
Similarity:	491/780 - (62%)	Gaps:	60/780 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLTT----TTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHS 61
            |:|:|    |.:..|:..:|............|||...|::||||||..|:|:|:|:||:.|::.
  Rat     1 MSLSTMASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG 65

  Fly    62 THSRKNSDTSQISLTSSGNSVA--EEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAI 124
              ||:||.:|.:|.:|:.::::  |||.|..|..|.|:||...:||...:.||:|:|||||||||
  Rat    66 --SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAI 128

  Fly   125 VWQQLSGASDGD-KKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSL 188
            |||.|..|:|.. |.||:|.:|.:|.|||:|||||||||||.||||.:|..|||.||||:|||||
  Rat   129 VWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSL 193

  Fly   189 HDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQ 253
            .||||||||||.||||||||||||||||.|.|::||::|:|.:|||||:|||||:||.|.::|||
  Rat   194 VDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQ 258

  Fly   254 IPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDT 318
            :||::.||:.|.|.|:||||||||||:.||..:.::.|:.|:|:.||:|.:|:|.||||...:..
  Rat   259 LPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQTE 323

  Fly   319 LLCLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRR 383
            |:.||||.|.::||:.:|.:.::..:.....||.:|.|.|:||::||||..:|.||.||..|::|
  Rat   324 LMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKR 388

  Fly   384 LRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENAN 448
            ||.||.|||||.|.||.|||.|||||::|||:||:|.|.:|.|:.||..:|:.....:..|:.|
  Rat   389 LRTENRLLKQRIETLEKESAALADRLIQGQVTRAQEAEENYVIKRELAVVRQQCSSTAEDLQKA- 452

  Fly   449 EEVRGLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQI 513
                                   ||:|.:|..::|..:..::.||.|..||.:.|....|:...:
  Rat   453 -----------------------QSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGAL 494

  Fly   514 RNLKAKVEELEEDKKTLRETTPD-NSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQ 577
            |.::.||.::|:...:|    || |:||.||:||.|.|:||.||..|.::||.::||||..||..
  Rat   495 REMQDKVLDMEKRNSSL----PDENNVARLQEELKALKVREGEAVASARELKLQLQELSDTWQAH 555

  Fly   578 LAENQRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREMETLTELKELRLKV 642
            ::...|.:         .:|:||:..            :|::||||.|:||.:.|.:.:|.|.:|
  Rat   556 VSRGGRWK---------ESPRKLVLG------------ELQDELMTMRLREAQALADGREWRQRV 599

  Fly   643 MELETQVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLESRMKDELMNVKI 707
            :|||||..:..|.|.|.:.|...|:|:|:....:.|.:..:..|.:.:.::.|.:.|:|:|.|::
  Rat   600 VELETQDNIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRL 664

  Fly   708 KFTEQSQTVAELKQEISRLETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSRGKF 772
            :..:....|||::|.|:.||.:..|...:|:|. :.|.|..:|:|:|::.::|.|:..||....|
  Rat   665 READSMAAVAEMRQRIAELEIQREEGRIQGQLN-HSDSSQYIRELKDQIEELKTEVRLLKGPPTF 728

Fly 773 772
Rat 729 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	132/207 (64%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	32/103 (31%)
Evi5l	XP_038945835.1	TBC	117..325	CDD:214540	132/207 (64%)
Evi5l	XP_038945835.1	SMC_prok_B	<381..719	CDD:274008	130/387 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1814
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm44905
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1412
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920