DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and gyp51

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_594886.1	Gene:	gyp51 / 2542680	PomBaseID:	SPAC26F1.09	Length:	1031	Species:	Schizosaccharomyces pombe

Alignment Length:	506	Identity:	122/506 - (24%)
Similarity:	226/506 - (44%)	Gaps:	70/506 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LNSLHSTHSRKNSDTSQISL---TSSGNSVAEEDIWTTWATILNDWEGALKRKNP------CVSE 111
            |.|:..:..|...|..::.:   ..|.:|.....::|..:..:         :||      |..|
pombe   547 LESVFISKPRSIGDAQKLEILEYLQSQSSTVSNQVFTLLSNFI---------QNPLFVLDECFDE 602

  Fly   112 ---LVRRGIPHHFRAIVWQQLSGASDGD-KKQYAEYIKATSACEKVIRRDIARTY-PEV--EFFK 169
               |:.....|....:||:.:|..:..| :.||:.........:|.||:|:.||: ||:  .||.
pombe   603 FRNLILMHNSHTVHTVVWKTISSWTSYDYEMQYSSLSIKNCDSDKAIRKDLDRTFAPEILSHFFS 667

  Fly   170 EK------DGPGQEA--LFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQH 226
            .:      |...:..  |..|:::.::...:|||.||..:|.|.|||.:|..:|||:||.:.:.:
pombe   668 NRQQLEPTDNIAESTANLHRVLRSLAIVLPQVGYTQGMSWIAGALLMHLPAPQAFALLVFLFKNY 732

  Fly   227 RMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCR 291
            .::::|...|..|...::|...||::.:|.:.|||::|..:|..|||.|||||:.....:.:...
pombe   733 HLQNIFSSEMRGLSRVLHQFTRLVEDYMPSLAIHFKRQDIKTCSYASEWFLTLFAYKFPLEVVAH 797

  Fly   292 IMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKELPGRVEADVEG-------FFNL 349
            :.|:....|...:|...||||...:::||.|:|:.::.:.::::....:...||       |...
pombe   798 LYDILFLYGPGILFNFGLALLSHSQESLLKLNMDRLISYLKEDIFLAFKETQEGENYDTSLFVKT 862

  Fly   350 AYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQV 414
            |:|.::....:.:...||..|.|.|.|..:.|..:|       .|::.|......|:|.:...||
pombe   863 AFSFEIQPDVLDRYGNEYDILLKSEHELDSSLEEMR-------NRHKSLNEHFIMLSDSMANLQV 920

  Fly   415 SRAEEEETSYAIQTELMQLRRSYLE----------VSHQLENANEEVR-----GLSLRLQEN-NV 463
               |.|..|..:..|.|.|:...:|          ::.||.....|:.     .:...:.|| .:
pombe   921 ---EHENMSALLLKEKMYLKNQTVEQASLKSEIASLNSQLAKQKSEIEQAFQGDMEAIIAENLEI 982

  Fly   464 SIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIR 514
            .::|    ||..||:..||:.|.:....::.|.|:.:...|..::..::|:
pombe   983 MVES----QSLEDEIFRKEKQLAETKVNLAVLDEDHMMALQKWSQLMNRIK 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	63/218 (29%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
gyp51	NP_594886.1	COG5210	233..890	CDD:227535	89/351 (25%)
		TBC	569..826	CDD:214540	71/265 (27%)
		PspA	889..>1024	CDD:224755	32/148 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm47026
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.800