DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Evi5 and SPBC1778.09

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_596292.1	Gene:	SPBC1778.09 / 2539715	PomBaseID:	SPBC1778.09	Length:	414	Species:	Schizosaccharomyces pombe

Alignment Length:	332	Identity:	82/332 - (24%)
Similarity:	135/332 - (40%)	Gaps:	47/332 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILN 96
            ||.:....|| ...||||..|          ...|..|.| |.:...|.|....:|.....:.:.
pombe    74 PTLDKPNPAK-RLGNKLIGHD----------DMLKYVDES-IFMVVPGESHDRNEISAKELSRIQ 126

  Fly    97 DWEGALKRKNPCVSELVR------------------RGIPHHFRAIVWQQLSGASDGDKKQYAEY 143
            .|      |:.|...||.                  :|||..:|:|.|......|..|||...:|
pombe   127 KW------KSMCSIHLVSGNQLHSFRKTRKLILRTFKGIPDCWRSIAWWSFLVDSLPDKKLIDKY 185

  Fly   144 IKAT-SACEKVIR--RDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGL 205
            .:.. ..|:..::  .|:.||......|:::...||..||.|:.|.:|:...|||.||...|...
pombe   186 YQLNEQICDYDVQIDLDVPRTAATHFLFRKRYIGGQRLLFRVLHAVALYIPRVGYVQGMASIAAT 250

  Fly   206 LLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTM 270
            ||:..|||:||.::|.:::...|..:|......|......|::  :........|..:.|.:.:.
pombe   251 LLIYYPEEQAFIMMVNLLENRGMGDLFSSGFDTLLKAFDMLKH--ELSFTQSGRHLAEIGAEPSA 313

  Fly   271 YASSWFLTLYTTTLNVNLSCRIMD-VFLSEG-----MEFIFKVALALLLTGKDTLLCLDMEAMLK 329
            :|:.|:||::...:..:...||.| :||..|     :..:...:||::....|||:..|.|.:::
pombe   314 FATRWYLTVFHQCVPFHTQLRIWDLLFLLGGSKGQTVRLLQATSLAVIQGMWDTLIDADFEVVMQ 378

  Fly   330 FFQKELP 336
            .....:|
pombe   379 ALSGVIP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	58/233 (25%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
SPBC1778.09	NP_596292.1	COG5210	1..403	CDD:227535	82/332 (25%)
SPBC1778.09	NP_596292.1	RabGAP-TBC	198..340	CDD:278964	38/143 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910