DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and TBC1D1

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_011511961.1	Gene:	TBC1D1 / 23216	HGNCID:	11578	Length:	1295	Species:	Homo sapiens

Alignment Length:	535	Identity:	139/535 - (25%)
Similarity:	243/535 - (45%)	Gaps:	99/535 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PGEENLPTS------------EMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSS 78
            |.||...||            :..||.::|..|:.:::....|     .:.|...|..:|
Human   836 PPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDL-----LNKRLKLDYEEI----- 890

  Fly    79 GNSVAEEDIWTTWATILN-DWEGALKRKNPCVSELVRRGIPHHFRAIVWQ----------QLSGA 132
              :...:::.|.|..:|: .....:|.....:...|.:|:|.|.|..:|:          |....
Human   891 --TPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSK 953

  Fly   133 SDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQ 197
            .......|.|.:|..::.:..|..|:.||:|...:|..:.|.||.:|:|::|||||.|:||||||
Human   954 QQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQ 1018

  Fly   198 GSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQ 262
            |..|:.|:||:.|.|||||.:|..:|....:|..::|.|..|.:.||||..|:.:...|::.|.:
Human  1019 GLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLE 1083

  Fly   263 QQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLD-MEA 326
            :.....::||:.||||::.:...:....|:.|:...:|.|.||||||:||.:.|..:|..: :|.
Human  1084 EHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLET 1148

  Fly   327 MLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLL 391
            ::.|.:..||......:|...|..:.:.: .|:::..|.||..|    |||:
Human  1149 IVDFIKSTLPNLGLVQMEKTINQVFEMDI-AKQLQAYEVEYHVL----QEEL------------- 1195

  Fly   392 KQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSL 456
                    .:|:.|:|   ..::.:.|:..:|         ||:..|::..||:.||..::.|
Human  1196 --------IDSSPLSD---NQRMDKLEKTNSS---------LRKQNLDLLEQLQVANGRIQSL-- 1238

  Fly   457 RLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVE 521
                           :::|::|...|..|||  .|::..||     |..|.::.:::|...|:..
Human  1239 ---------------EATIEKLLSSESKLKQ--AMLTLELE-----RSALLQTVEELRRRSAEPS 1281

  Fly   522 ELEEDKKTLRETTPD 536
            : .|.:.|..|.|.|
Human  1282 D-REPECTQPEPTGD 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	76/216 (35%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
TBC1D1	XP_011511961.1	PTB	21..150	CDD:269911
		PTB_TBC1D1_like	164..391	CDD:269967
		CytochromB561_N	563..>871	CDD:286826	9/34 (26%)
		DUF3350	822..872	CDD:288663	9/35 (26%)
		TBC	924..1141	CDD:214540	76/216 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810