Protein Alignment Evi5 and TBC1D9

DIOPT Version :10

• Sequence 1: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_055945.2
• Gene: TBC1D9 / 23158
• HGNCID: 21710
• Length: 1266
• Species: Homo sapiens
• Alignment Length: 768
• Identity: 177/768 - (23%)
• Similarity: 277/768 - (36%)
• Gaps: 235/768 - (30%)

  Fly     3 LTTTTTASSAESQAKMDVKGGALPGEENLPT-----------SEMDLLAK-----LEAANKLIES 51
            |...|....|:|.:       .||...::.|           .:.|.|.:     |:.....|.|
Human   351 LREVTIVEKADSSS-------VLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYS 408

  Fly    52 D---AKSLNS----LHSTHSRKNSDTSQISLTS----------SGNSV--AEEDIWT-------- 89
            |   |.|.||    ::|..|...|.:.|.|.:|          :||||  |.:.:.|
Human   409 DKEFAGSYNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPE 473

  Fly    90 --------------TWATILNDW-EGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGA------- 132
                          .|.....:: :|....:.....|||.:|||...|..:|..||||
Human   474 EFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATH 538

  Fly   133 ----SDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREV 193
                .|..:|...:|..||    :.|.||:.|:.||...|:.:  .|..||..|:.||:..:..:
Human   539 PGYYEDLVEKSMGKYNLAT----EEIERDLHRSLPEHPAFQNE--MGIAALRRVLTAYAFRNPNI 597

  Fly   194 GYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQ--LENLVQEQIPD 256
            ||||....:..:||:...|||||.:||.:.:  ||...:. :...:|..:.|  .|.|.::.:|.
Human   598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCE--RMLPDYY-NTRVVGALVDQGVFEELARDYVPQ 659

  Fly   257 MHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLL- 320
            ::...|..|..:|: :.||||||:.:.:....:..::|.|..||::.||::|||:|....|.||
Human   660 LYDCMQDLGVISTI-SLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLN 723

  Fly   321 CLD----MEAMLKFFQK------------ELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQD 369
            |.|    |..:.::...            .|...:..|||.:                .|.:...
Human   724 CKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPY----------------PEVDIFR 772

  Fly   370 LKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQ--TELMQ 432
            |.:...|:...:|....|....|||.::::.    |.|...| .|.|....|||:.|.  .||..
Human   773 LIRTSYEKFGTIRADLIEQMRFKQRLKVIQT----LEDTTKR-NVVRTIVTETSFTIDELEELYA 832

  Fly   433 LRRS-----------------------YLEVSHQLENANEEVRG----------------LSLR- 457
            |.::                       |||   |.....|:.:|                |:.|
Human   833 LFKAEHLTSCYWGGSSNALDRHDPSLPYLE---QYRIDFEQFKGMFALLFPWACGTHSDVLASRL 894

  Fly   458 ---LQENNVSIDSNNSRQSSIDELCMKE--EALK-------------QRDEMVSC------LLEE 498
               |.||..|:.:.....|.:...|..:  |.||             .:||..|.      ..|:
Human   895 FQLLDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFED 959

  Fly   499 LV-----------KVRQGLAESED-----QIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELI 547
            :.           :.:||   ::|     .::..|.|....:|::..||..||:|.
Human   960 ITPECTHVVGLDSRSKQG---ADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENK--------- 1012

  Fly   548 ASKLREAEASLSLKDLKQRVQ----ELSSQWQRQLAEN-QRSESERTTNAVDS 595
             ||.:.|      |||.:..|    ||........:|: ...|....|.||.|
Human  1013 -SKSKNA------KDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTS 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	68/219 (31%)
		Smc	<358..>761	CDD:440809	67/325 (21%)
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	9/54 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..456		11/40 (28%)
		TBC	512..722	CDD:214540	68/219 (31%)
		EFh	<893..923	CDD:415501	7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1075..1095
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1132..1164