Protein Alignment Evi5 and Tbc1d4

DIOPT Version :9

• Sequence 1: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_006518822.1
• Gene: Tbc1d4 / 210789
• MGIID: 2429660
• Length: 1307
• Species: Mus musculus
• Alignment Length: 578
• Identity: 144/578 - (24%)
• Similarity: 247/578 - (42%)
• Gaps: 134/578 - (23%)

  Fly    25 LPGEENLPTSEMDLL----------AKLEAANKLIESDAKSL--NSLH--------STHSRKNSD 69
            ||.....||.|.:.|          .|:|...|  ..:.|||  .::|        ...::|..:
Mouse   811 LPLSPLSPTMEEEPLIIFLSGDEDTEKVEEKKK--SKELKSLWKKAIHQQILLLRMEKENQKLEE 873

  Fly    70 TSQISLTSSGNSVAEEDIWTTWATILNDWEGAL---KRKNPC----VSELVRRGIPHHFRAIVWQ 127
            ..:..|.|....:..|::.|....||..|:..|   :.|..|    :...::.|:|...|..:||
Mouse   874 ARRDELQSRKVKLDYEEVGTCQKEILIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQ 938

  Fly   128 ----------QLSGASDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNV 182
                      :|..........|.|.:|..:|.:..|..|:.||:|...:|..:.|.||.:|||:
Mouse   939 FLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNL 1003

  Fly   183 IKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLE 247
            :|||||.|:|||||||..|:.|:||:.|.||:||.:|..:|.....|..::|.|..|.:.||||.
Mouse  1004 LKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLS 1068

  Fly   248 NLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALL 312
            .|:.:...:::.|.::.....::||:.|||||:.:...:....|:.|:...:|.|.||||||: |
Mouse  1069 RLLHDYHRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALS-L 1132

  Fly   313 LTGKDTLL--CLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQ 375
            |:.::.|:  |.:.|.:::|.:..||.....::|......:.:.: :|::...|.||..|
Mouse  1133 LSSQEALIMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDI-SKQLHAYEVEYHVL----- 1191

  Fly   376 EEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEV 440
                              ::||||:..|             .|:.|:...::....||:|..:::
Mouse  1192 ------------------QDELLESSYA-------------CEDNESLEKLERANNQLKRQNMDL 1225

  Fly   441 SHQLENANEEVRGLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQG 505
            ..:|:.|:.:::.|                 :|:::.|..:|
Mouse  1226 LEKLQVAHAKIQAL-----------------ESNLETLLTRE----------------------- 1250

  Fly   506 LAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDL 563
                    ..:||.:..||:||...::|     |..::..|.|..|  |...|.||||
Mouse  1251 --------TKMKALIRTLEQDKMAYQKT-----VEQIRKLLPADAL--ANCELLLKDL 1293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	75/216 (35%)
		DUF4527	627..>731	CDD:291689
Tbc1d4	XP_006518822.1	PTB	31..190	CDD:214675
		PTB_TBC1D1_like	193..444	CDD:269967
		DUF3350	814..872	CDD:371748	12/59 (20%)
		TBC	927..1141	CDD:214540	76/214 (36%)
		PTZ00440	<1141..>1272	CDD:240419	34/220 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840