DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and myo-1

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_492053.1	Gene:	myo-1 / 172471	WormBaseID:	WBGene00002348	Length:	1938	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	181/909 - (19%)
Similarity:	351/909 - (38%)	Gaps:	255/909 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSL-HSTHSRKNSDT 70
            |.||..:.:|.:...|..:..|:.| .:.:...:| |.|.::||.:    :.| |...||..:|.
Worm  1083 TDASLKKKEADIHALGVRIEDEQAL-ANRLTRQSK-ENAQRIIEIE----DELEHERQSRSKADR 1141

  Fly    71 SQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASDG 135
            ::..|...                |::....|..:|                    :||....|.
Worm  1142 ARAELQRE----------------LDELNERLDEQN--------------------KQLEIQQDN 1170

  Fly   136 DKKQYAEYIKATSACEKVIRRDI----ARTYPEVEFFKEKDGPGQEALFNVI----KAYSLHDRE 192
            :||:.:|.||        .|||:    .....::...:.|:.....||.|.:    |:.:..::|
Worm  1171 NKKKDSEIIK--------FRRDLDEKNMANEDQMAMIRRKNNDQISALTNTLDALQKSKAKIEKE 1227

  Fly   193 VGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDM 257
            .|..|..   :..:..|:.:|....|     :|.|:...::..::|       |:..|.||
Worm  1228 KGVLQKE---LDDINAQVDQETKSRV-----EQERLAKQYEIQVAE-------LQQKVDEQ---- 1273

  Fly   258 HIHFQQQGFQTTMYASSWFLTLYTTTL------NVNLSCRIMDVFLSEGMEFIFKVALALLLTGK 316
                            |..:..||:|.      |.:|:.::.::          ::.||.:...|
Worm  1274 ----------------SRQIGEYTSTKGRLSNDNSDLARQVEEL----------EIHLATINRAK 1312

  Fly   317 DTLLCLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAE- 380
            .......:||. |..:.||..|.|      |:.|         .|.:|.|.....:..:|::..
Worm  1313 TAFSSQLVEAK-KAAEDELHERQE------FHAA---------CKNLEHELDQCHELLEEQINGK 1361

  Fly   381 ---LRRLRRENCLLKQRNELLEAE---SAELADRLVRGQVSRAEE-EETSYAIQTELMQLRRSYL 438
               .|:|.|.|..:.|.....|.|   .:|..:.|.|.|::|..: :|...|.|.:::.|.::..
Worm  1362 DDIQRQLSRINSEISQWKARYEGEGLVGSEELEELKRKQMNRVMDLQEALSAAQNKVISLEKAKG 1426

  Fly   439 EVSHQLENANEEV-RGLS-------------------------LRLQENNVSIDSNNSR------ 471
            ::..:.|:|..:| |.|:                         ::.:.:..:.||.|:.
Worm  1427 KLLAETEDARSDVDRHLTVIASLEKKQRAFDKIVDDWKRKVDDIQKEIDATTRDSRNTSTEVFKL 1491

  Fly   472 QSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPD 536
            :||:|.|..:.|.|::.:::.|   :|:..:.:.:.:.....:.:...|..||::|..|:
Worm  1492 RSSMDNLSEQIETLRRENKIFS---QEIRDINEQITQGGRTYQEVHKSVRRLEQEKDELQ----- 1548

  Fly   537 NSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAENQRSESERT----TNAVDSTP 597
                |..||  |....|||.|..|: |:..||::.|:.::::.|.: .|.|.|    ..|::|..
Worm  1549 ----HALDE--AEAALEAEESKVLR-LQIEVQQIRSEIEKRIQEKE-EEFENTRKNHQRALESIQ 1605

  Fly   598 KKLLTNFFDSSKSSEHTQKLEEELMTTRI-------REMETLTELKELRLKVMELETQVQVSTNQ 655
            ..|.|.....::.:...:|||.::....|       ..::....||:|..:|.||  |.||...|
Worm  1606 ASLETEAKSKAELARAKKKLETDINQLEIALDHANKANVDAQKNLKKLFDQVKEL--QGQVDDEQ 1668

  Fly   656 LRRQD--EEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLE--------------------SRM 698
            .||::  |.:...::.|.:|::..:|::::..........||                    |.|
Worm  1669 RRREEIRENYLAAEKRLAIALSESEDLAHRIEASDKHKKQLEIEQAELKSSNTELIGNNAALSAM 1733

  Fly   699 KDELMN-VKIKFTEQSQTVAELK--QEISRLETKNSEMLAE-----------------------G 737
            |.::.| |:|...|..:.:.|||  :|.:|....:::.|||                       .
Worm  1734 KRKVENEVQIARNELDEYLNELKASEERARKAAADADRLAEEVRQEQEHAVHVDRQRKSLELNAK 1798

  Fly   738 ELRANLDDSDK---------VRDLQDRLADMKAELTALKSRGKFPGAKLRSSSIQSIESTEIDF 792
            ||:|.:||:::         :..::||:..::|||.:.:.|.:   ..::..:.|...:.|:.|
Worm  1799 ELQAKIDDAERAMIQFGAKALAKVEDRVRSLEAELHSEQRRHQ---ESIKGYTKQERRARELQF 1859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	38/220 (17%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	30/128 (23%)
myo-1	NP_492053.1	Myosin_N	33..71	CDD:280832
		Myosin_head	86..773	CDD:278492
		MYSc_class_II	98..773	CDD:276951
		Myosin_tail_1	854..1918	CDD:279860	181/909 (20%)
		P-loop_NTPase	<863..>1071	CDD:304359
		DUF2213	<1074..1224	CDD:303028	37/190 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000