DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and EVI5L

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001153416.1	Gene:	EVI5L / 115704	HGNCID:	30464	Length:	805	Species:	Homo sapiens

Alignment Length:	748	Identity:	329/748 - (43%)
Similarity:	482/748 - (64%)	Gaps:	56/748 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVA--EEDIWTTW 91
            |||...|::||||||..|:|:|:|:||:.|::.  ||:||.:|.:|.:|:.::::  |||.|..|
Human    28 ENLSPDELELLAKLEEQNRLLEADSKSMRSMNG--SRRNSGSSLVSSSSASSNLSHLEEDTWILW 90

  Fly    92 ATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASDGD-KKQYAEYIKATSACEKVIR 155
            ..|.|:||...:||...:.||:|:||||||||||||.|..|:|.. |.||:|.:|.:|.|||:||
Human    91 GRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIR 155

  Fly   156 RDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLV 220
            |||||||||.||||.:|..|||.||||:|||||.||||||||||.||||||||||||||||.|.|
Human   156 RDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV 220

  Fly   221 QIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLN 285
            ::||::|:|.:|||||:|||||:||.|.::|||:||::.||:.|.|.|:||||||||||:.||..
Human   221 RLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFP 285

  Fly   286 VNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKELPGRVEADVEGFFNLA 350
            :.::.|:.|:|:.||:|.:|:|.||||...:..|:.||||.|.::||:.:|.:.::..:.....|
Human   286 LPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKA 350

  Fly   351 YSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVS 415
            |.:|.|.|:||::||||..:|.||.||..|::|||.||.|||||.|.||.|||.|||||::|||:
Human   351 YQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVT 415

  Fly   416 RAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLRLQENNVSIDSNNSRQSSIDELCM 480
            ||:|.|.:|.|:.||..:|:.....:..|:.|                        ||:|.:|..
Human   416 RAQEAEENYVIKRELAVVRQQCSSAAEDLQKA------------------------QSTIRQLQE 456

  Fly   481 KEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPD-NSVAHLQD 544
            ::|..:..::.||.|..||.:.|....|:...:|.::.||.::|:...:|    || |:||.||:
Human   457 QQENPRLTEDFVSHLETELEQSRLRETETLGALREMQDKVLDMEKRNSSL----PDENNVAQLQE 517

  Fly   545 ELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSK 609
            ||.|.|:||.:|..|.::||.::||||..||..||...|.:         .:|:||:..
Human   518 ELKALKVREGQAVASTRELKLQLQELSDTWQAHLARGGRWK---------ESPRKLVVG------ 567

  Fly   610 SSEHTQKLEEELMTTRIREMETLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELEMAV 674
                  :|::|||:.|:||.:.|.|.:|||.:|:|||||..:..|.|.|.:.|...|:|:|:...
Human   568 ------ELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRVEAERAALQEKLQYLA 626

  Fly   675 TREKDMSNKAREQQHRYSDLESRMKDELMNVKIKFTEQSQTVAELKQEISRLETKNSEMLAEGEL 739
            .:.|.:..:..|.:.:.::.|.:.|:|:|.|:::..:....|||::|.|:.||.:..|...:|:|
Human   627 AQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEMRQRIAELEIQREEGRIQGQL 691

  Fly   740 RANLDDSDKVRDLQDRLADMKAELTALKSRGKF 772
            . :.|.|..:|:|:|::.::|||:..||....|
Human   692 N-HSDSSQYIRELKDQIEELKAEVRLLKGPPPF 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	132/207 (64%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	34/103 (33%)
EVI5L	NP_001153416.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75		11/27 (41%)
		TBC	112..320	CDD:214540	132/207 (64%)
		SMC_prok_B	<376..719	CDD:274008	135/392 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..805
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1836
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1042
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46583
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm40765
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880