Protein Alignment Evi5 and TBC1D8

DIOPT Version :10

• Sequence 1: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001317277.1
• Gene: TBC1D8 / 11138
• HGNCID: 17791
• Length: 1155
• Species: Homo sapiens
• Alignment Length: 847
• Identity: 169/847 - (19%)
• Similarity: 294/847 - (34%)
• Gaps: 261/847 - (30%)

  Fly    38 LLAKLEA--ANKLIESDAKSLNSL-----HSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATIL 95
            |||:|:.  ||..:..|..:.:.:     |||....:.....:.:.||.||...|
Human   402 LLARLKQVHANHPVHYDTSADDDMASLVFHSTSMCSDHRFGDLEMMSSQNSEESE---------- 456

  Fly    96 NDWEGALKRKNP--------------------------------------------C------VS 110
                   |.|:|                                            |      :.
Human   457 -------KEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIR 514

  Fly   111 ELVRRGIPHHFRAIVWQQLSGASDGDKKQYAEYI-----KATSAC---EKVIRRDIARTYPEVEF 167
            :||..|||...|..:|...|.|.. |...:..|.     ::...|   .:.|.||:.|:.||...
Human   515 KLVAMGIPESLRGRLWLLFSDAVT-DLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPA 578

  Fly   168 FKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQ------- 225
            |:.:.|..  ||..|:.||:..:.::||||....:..:||:...|||||.:||.:.::
Human   579 FQNETGIA--ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFN 641

  Fly   226 HRMRHMFKPSMSELGLCMYQ--LENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNL 288
            ||:          :|..:.|  .|.|::..:|::..|........:: :.||||||:.:.:.:..
Human   642 HRV----------IGAQVDQSVFEELIKGHLPELAEHMNDLSALASV-SLSWFLTLFLSIMPLES 695

  Fly   289 SCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCL---DMEAML---KFF----QKELPGRVEADV 343
            :..::|.|..:|::.||::.||:|....:. ||.   |.:|::   :|.    .::.||......
Human   696 AVNVVDCFFYDGIKAIFQLGLAVLEANAED-LCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSH 759

  Fly   344 EGFFN---LAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLR---------RENCL--LKQR 394
            ..||:   ..|.:...:..::...:::.|...::.|.:....|:|         ::|.|  :...
Human   760 HAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHRIRVLQGHEDTTKQNVLRVVIPE 824

  Fly   395 NELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLR----RSYLE---------------V 440
            ..:|..:..||.|...|      |...:.|..|...|..|    |.|.|               |
Human   825 VSILPEDLEELYDLFKR------EHMMSCYWEQPRPMASRHDPSRPYAEQYRIDARQFAHLFQLV 883

  Fly   441 SHQLENANEEVRG-LSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCL-------LE 497
            |.....|:.|:.. .:.||.::|:                   :.|.:....||||       :.
Human   884 SPWTCGAHTEILAERTFRLLDDNM-------------------DQLIEFKAFVSCLDIMYNGEMN 929

  Fly   498 ELVKVRQGL----------AESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLR 552
            |.:|:...|          .:|:..:||      .|....:.|....|:......|
Human   930 EKIKLLYRLHIPPALTENDRDSQSPLRN------PLLSTSRPLVFGKPNGDAVDYQ--------- 979

  Fly   553 EAEASLSLKDLKQRVQELSSQWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKL 617
                    |.|||.:::|:            .|.::|...:....::....|..:..|..|....
Human   980 --------KQLKQMIKDLA------------KEKDKTEKELPKMSQREFIQFCKTLYSMFHEDPE 1024

  Fly   618 EEELMTTRIREMETLTEL----------------------KELRLKVMELETQVQVSTNQLRRQD 660
            |.:|    .:.:.|:|.|                      :|||......|..|...|.: ..||
Human  1025 ENDL----YQAIATVTTLLLQIGEVGQRGSSSGSCSQECGEELRASAPSPEDSVFADTGK-TPQD 1084

  Fly   661 EEHKKLKEELEMAVTREKDMSNKAREQQ-HRYSDLESRMKDELMNVKIK------FTEQSQTVAE 718
            .:......|.:..|:.|..:::...||. ..:.:....||.:|.|.||.      |....|:.:|
Human  1085 SQAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAKINQYNLKTFEMSHQSQSE 1149

  Fly   719 LK 720
            ||
Human  1150 LK 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	59/223 (26%)
		Smc	<358..>761	CDD:440809	80/440 (18%)
TBC1D8	NP_001317277.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160	3/3 (100%)
		TBC	520..726	CDD:214540	58/220 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1085		7/39 (18%)