DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and Evi5

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_006250585.2	Gene:	Evi5 / 100360066	RGDID:	2322879	Length:	882	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	353/812 - (43%)
Similarity:	509/812 - (62%)	Gaps:	81/812 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TLTTTTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRK 66
            ||:|.|.:.|:.|:...|               :::||||||..|:|||:|:|||.|::.  ||:
  Rat    77 TLSTPTQSPSSPSKLSPD---------------DLELLAKLEEQNRLIETDSKSLRSVNG--SRR 124

  Fly    67 NSDTSQISLTSSGNSVA--EEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQL 129
            ||.:|.:|.:|:.::::  |||.|..|..|:|:|:...|:|...|.||||:||||||||||||.|
  Rat   125 NSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWDDVRKKKEKQVKELVRKGIPHHFRAIVWQLL 189

  Fly   130 SGASDGD-KKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREV 193
            ..|.... |.||:|.:|.||.|||:|||||||||||..||||||..|||.||||:|||||.||||
  Rat   190 CDAQTMPVKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREV 254

  Fly   194 GYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMH 258
            ||||||.|||||||:||||||||.|..::||.:|:|.:|||||:||||||||.|.::||.:|::.
  Rat   255 GYCQGSAFIVGLLLLQMPEEEAFCVFFKLMQDYRLRELFKPSMAELGLCMYQFECMIQEYLPELF 319

  Fly   259 IHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLD 323
            :|||.|.|.|:|||||||||::.||..:.::.||.|:|:|||:|.:|:|.||||...:..|:.||
  Rat   320 VHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD 384

  Fly   324 MEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRREN 388
            ||.||:.|||.:|.:.:...|.....||.:|.|:|:|||:||||..:|.||.||..|::|||.||
  Rat   385 MEGMLQHFQKVIPHQFDGGPEKLIQSAYQVKYNSKKMKKLEKEYTTIKTKEMEEQGEIKRLRTEN 449

  Fly   389 CLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRG 453
            .|||||.|.||.|||.|||||::|||:||:|.|.:|.|:.||..:::.......:||.|...:|.
  Rat   450 RLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQTDAARAKLEQAESTIRE 514

  Fly   454 LSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKA 518
            |......:..|...|                    ::.|..|.:|||:.|...|||:..::.::.
  Rat   515 LQHHRHWHKCSSTYN--------------------EDFVLQLEKELVQARLSEAESQCALKEMQD 559

  Fly   519 KVEELEEDKKTLRETTPD-NSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAENQ 582
            ||.::|:...:.    || |::|.||:||||.|||||||.:.||:|:|:|::|...|||.:|
  Rat   560 KVLDIEKKNNSF----PDENNIARLQEELIAVKLREAEAIMGLKELRQQVRDLEEHWQRHVA--- 617

  Fly   583 RSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREMETLTELKELRLKVMELET 647
                 ||:......||:            ....:|:.|||:.|:||.||..|::|::.::||:||
  Rat   618 -----RTSGRWKDPPKR------------NAVSELQGELMSIRLREAETQAEMREMKQRMMEMET 665

  Fly   648 QVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLESRMKDELMNVKIKFTEQ 712
            |.|:::|||||.::|...|:|::.....:.|.:..:..|.:.|.:::|.:.|:|:|.|:::..:.
  Rat   666 QNQINSNQLRRAEQEVTSLQEKVCSLSLKNKGLLAQLSEAKRRQAEIECKNKEEVMAVRLREADS 730

  Fly   713 SQTVAELKQEISRLETKNSEMLAEGELRANLDDSDK---VRDLQDRLADMKAELTALK------S 768
            ...||||:|.|:.||.:..    ||:|:..|:.||.   :|:|:|::|::..||..||      |
  Rat   731 IAAVAELQQHIAELEIQKE----EGKLQGQLNRSDSKQYIRELKDQIAELTHELRCLKGQRDFSS 791

  Fly   769 RGKFPGAKLRSSSI---QSIESTEIDFNDLNM 797
            |..|.|..:.|..|   :|..|::.||.|.::
  Rat   792 RPPFDGIHIVSHLIGDDESFHSSDEDFIDSSL 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	133/207 (64%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	36/103 (35%)
Evi5	XP_006250585.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1814
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121902
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1265
OMA	1	1.010	-	-		QHG46583
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm44905
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880