DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Magi3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001152826.1	Gene:	Magi3 / 99470	MGIID:	1923484	Length:	1476	Species:	Mus musculus

Alignment Length:	1225	Identity:	246/1225 - (20%)
Similarity:	411/1225 - (33%)	Gaps:	384/1225 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EREKSSDPNEGLLSSD--DKTFHDDDEPAEDSSP----------ADDEEEPEEE----------- 49
            |:.|:.:.:..||.|.  |..|:...:|..:.||          .|:|.:.|.:
Mouse   168 EQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKME 232

  Fly    50 --ECLLPQKKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDD-----------TNPVAVAAKASDM 101
              :..||::      ::|:....|....|.|..|:..|..|           ||        |.|
Mouse   233 RMDSSLPEE------EEDEDKEAVNGSGSMETREMHSETSDCWMKTVPSYNQTN--------SSM 283

  Fly   102 D------GDSQLE-----------------VMEHQMETVTEPDP---EPPKCPTSLRDSVRESVE 140
            |      .|..||                 .::|..:|.|..||   :..|.|....|.     |
Mouse   284 DFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDG-----E 343

  Fly   141 CFYSAQDLLE------YGHMLSSTSMVRTP--------------------DVESGYFEKSESDAS 179
            ..|..:.:.:      |...|:..:....|                    |||..:|.:..|...
Mouse   344 LPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQAEIHSAKTDVERAHFTRDPSQLK 408

  Fly   180 ------------------------RDEW--------EGPSSSSSGAARCRLLSGISGLSVSSSSR 212
                                    .||:        :||::.....|...::..|:|..|...:.
Mouse   409 GVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 473

  Fly   213 HSA----------EGLRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKPKP-------KQRS 260
            ...          :.:.:.|.|...:.:..|...::...:...:..:|..|.:.       |..:
Mouse   474 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNTQDFKLGA 538

  Fly   261 HVQDAAGESGSEQGSER--GFWSTIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSEPQ 323
            .|.|..|:||....|:|  |...:...:|.||.|...:..:..|              ..:..|:
Mouse   539 MVLDQNGKSGQILASDRLNGPSESSEQRASLASSGSSQPELVTI--------------PLIKGPK 589

  Fly   324 DRALRIAI----ERVIRIFKSRLFQALLD---IQEFYELTLLDDSKSIQQKTAETLQIATKWEKD 381
            .....||.    ::|..|..|:..|.|..   |:|.|.       :::|..|  .||:.   |..
Mouse   590 GFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYH-------QNVQNLT--HLQVV---EVL 642

  Fly   382 GQAVKIADNQRMRIE----SDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQ 442
            .|....||...:.:.    |.|:.||..|   ..|:......:...|..| |.....|..||||.
Mouse   643 KQFPVGADVPLLILRGGPCSPTKTAKTKT---DTKENSGSLETINEPIPQ-PMPFPPSIIRSGSP 703

  Fly   443 TVNGDDSW-----LYE---------DIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGA 493
            .::..:.:     |||         |:.|.:..||.||.:.||.     |.|.||||..:|..||
Mouse   704 KLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD-----GPDQSIYIGAIIPLGA 763

  Fly   494 AAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKA---GNVV-----KLHVKRKRGTATTPAAG 550
            |..||||...|.::.::.:.|....|...:|.:..|   |:|:     |:....|:....:..|.
Mouse   764 AEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESHQAF 828

  Fly   551 SAAGDARDSAASGP------KVIEIDLV-KGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAA 608
            |..|..|.:.|..|      :..::.|. |..:|.||.|... .::..||.....:.:::||..|
Mouse   829 SQNGSPRLNRAELPTRSAPQEAYDVTLQRKENEGFGFVILTS-KSKPPPGVIPHKIGRVIDGSPA 892

  Fly   609 QVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTL-IIGKTQHLTTSASGGGGGG 672
            ...|.|.:||.:.||  ||  :::.:::|:..|..:|.....||| ::.:.:|      .|...|
Mouse   893 DRCGGLKVGDHISAV--NG--QSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEH------HGPPSG 947

  Fly   673 LSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTE-PGSRYASTNVLAA-VPPGTPRAVST 735
            .:|.:            ||.:..|:     ||..:|:.. ||.|.|....:.. |......:.|.
Mouse   948 TNSAR------------QSPALQHR-----PMGQAQANHIPGDRIALEGEIGRDVCSSYRHSWSD 995

  Fly   736 EDITREPRT------------------ITIQKGPQGLGFNIVGGED-GQGIYVSFILAGGPADLG 781
            .....:|.|                  :.:::||:|.||::.||:: ..|:::..:...|||...
Mouse   996 HKHLAQPDTAVISVVGSRHNQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKD 1060

  Fly   782 SELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRP--------------------- 825
            ..:..|||::.:|.......||..|.:.::..|..|.||  .||
Mouse  1061 GRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLL--LRPGTGLIPDHGDWDTNSPSSSNV 1123

  Fly   826 ------------EEYNRFE-----------ARIQ------ELK---QQAALGAGGSGTLLRTTQK 858
                        ...:.||           .|:|      |||   |:......||    :...|
Mouse  1124 IYDEQPPPLPSSHSASTFEESHVPATEDSLTRVQICEKAEELKDTVQEKKSTLNGS----QPEMK 1184

  Fly   859 RSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDN------------- 910
            .....:.:...||.|..|         ||              :..|:.|:|
Mouse  1185 YQSVHKTMSKKDPPRGSG---------HG--------------EKSRLKGENGVTRRGRSASPKK 1226

  Fly   911 -----EDEQIGIVPSKRRWERKMRARDRSVK-FQGHAAANNNLDKQSTLDRKKKN 959
                 .:|.:..:|...:.:.|.::||||:. .:|.:.....:...|..|..:|:
Mouse  1227 SVNRHSEEHLEKIPRPLKSDPKEKSRDRSLSPRKGESKGRLTIKAGSGQDPNRKD 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	11/62 (18%)
		PDZ	454..540	CDD:214570	30/93 (32%)
		PDZ_signaling	566..655	CDD:238492	25/90 (28%)
		PDZ_signaling	742..820	CDD:238492	22/96 (23%)
		SH3_DLG-like	862..922	CDD:212795	11/77 (14%)
Magi3	NP_001152826.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:15652357	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:302627	8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		16/87 (18%)
		WW	297..329	CDD:197736	5/31 (16%)
		WW	345..375	CDD:238122	4/29 (14%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		9/81 (11%)
		PDZ	416..496	CDD:214570	9/79 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..575		7/23 (30%)
		PDZ	578..659	CDD:214570	20/106 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..691		7/30 (23%)
		PDZ	729..812	CDD:214570	29/87 (33%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		29/86 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		7/25 (28%)
		PDZ_signaling	851..936	CDD:238492	25/89 (28%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		25/91 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..966		9/49 (18%)
		PDZ_signaling	1023..1101	CDD:238492	22/79 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1151		2/41 (5%)
		MIP-T3	<1166..>1431	CDD:287245	25/143 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1476		24/141 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810