DRSC/TRiP Functional Genomics Resources

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Protein Alignment dlg1 and DLG5

DIOPT Version :9

Sequence 1:NP_001162718.1 Gene:dlg1 / 32083 FlyBaseID:FBgn0001624 Length:1030 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:980 Identity:205/980 - (20%)
Similarity:348/980 - (35%) Gaps:258/980 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 EEEPEEEECLLPQKKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMDGD--- 104
            ||:.:|...|..|::..::.:.....|..|...:.:.:||.::..|......:.|.:..:.|   
Human   273 EEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSR 337

  Fly   105 ------------SQLEVMEHQMETVTEPDPEPPKCPTSLR--DSVRESV-ECFYSAQDLLEYGHM 154
                        .|.|::..|.:|..:...:   |..|||  :::...: :.....:||.....:
Human   338 LEQLGEENQRLLKQTEMLTQQRDTAIQLQHQ---CALSLRRFEAIHHELNKATAQNKDLQWEMEL 399

  Fly   155 LSS------TSMVRTPDVESGYFEKSESDASRDEWEGPSSSSSGAARCRLLSGISGLSVSSSSRH 213
            |.|      |:.|:|......|  :.|.||...|::                    |.:|...:.
Human   400 LQSELTELRTTQVKTAKESEKY--REERDAVYSEYK--------------------LIMSERDQV 442

  Fly   214 SAEGLRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERG 278
            .:|                    |:|.|:|::| |:||.|....::.    ||.|   |..:.|.
Human   443 ISE--------------------LDKLQTEVEL-AESKLKSSTSEKK----AANE---EMEALRQ 479

  Fly   279 FWSTIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLF 343
            ...|:...||               :|::.:|:|......|.:....||:.|  .|.:..:...|
Human   480 IKDTVTMDAG---------------RANKEVEILRKQCKALCQELKEALQEA--DVAKCRRDWAF 527

  Fly   344 QALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVE 408
            |.             .|....::.:..||....:.|:|....::|  :.:|...||...|. .|.
Human   528 QE-------------RDKIVAERDSIRTLCDNLRRERDRAVSELA--EALRSLDDTRKQKN-DVS 576

  Fly   409 QQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDS--WLYEDIQLERGN-----SGLGF 466
            ::.|:.:.|..|....:.:..|....|...|...|    ||  |..|.::.||..     ..|||
Human   577 RELKELKEQMESQLEKEARFRQLMAHSSHDSAIDT----DSMEWETEVVEFERETEDIDLKALGF 637

  Fly   467 SIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGN 531
            .:|.|.:.|....|..|::||:..|  :.|||||.:||.::.:|||.:::.....|:.||.....
Human   638 DMAEGVNEPCFPGDCGIFVTKVDKG--SIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEG 700

  Fly   532 VVKLHVKRKR---GTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPG 593
            .:.:.|:|::   |...||                   :.|:| .|.|..|.|:           
Human   701 AINMVVRRRKSLGGKVVTP-------------------LHINL-SGQKDSGISL----------- 734

  Fly   594 DNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKT 658
            :||:|...::.|..|..:|.|::||:::|:  ||..  |:|.:.....:.|:|..|.:||.:.|.
Human   735 ENGVYAAAVLPGSPAAKEGSLAVGDRIVAI--NGIA--LDNKSLNECESLLRSCQDSLTLSLLKV 795

  Fly   659 QHLTTSASGGGGGGLSSGQQLSQSQSQLA--TSQSQSQVHQQQHATPMVNSQST----------- 710
            ...::|.|     |.:..:.:..|...|:  ....:.|.|.:::.....||..|           
Human   796 FPQSSSWS-----GQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDR 855

  Fly   711 -EPGSRYASTNVLAAVPPGTP--------------------------RAVSTEDIT-REP-RTIT 746
             |||....|::.|....||.|                          |.....|:. |.| ....
Human   856 KEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFE 920

  Fly   747 IQKGPQGLGFNIVGGEDGQGIYVSFILAGG------------PADLGSELKRGDQLLSVNNVN-- 797
            .:.||.|:|...:...|.:|..     :||            |..| |..|:..|..|:.:.|  
Human   921 TEVGPCGVGEASLDKADSEGSN-----SGGTWPKAMLSSTAVPEKL-SVYKKPKQRKSIFDPNTF 979

  Fly   798 ------------LTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGS- 849
                        |.......:.|..|.:|.:.......|.:.. :|:.|::...:..|...|.| 
Human   980 KRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSI-KFQHRLETSSESEATLVGSSP 1043

  Fly   850 --------------GTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEW 900
                          |..:..:..|...||....|.|..|.  .|..||.|......:|:...||.
Human  1044 STSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDG--DSSHLPAKKSCDEDLTSQKVDEL 1106

  Fly   901 WQARR 905
            .|.||
Human  1107 GQKRR 1111

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dlg1NP_001162718.1 L27_1 303..359 CDD:286187 10/55 (18%)
PDZ 454..540 CDD:214570 27/90 (30%)
PDZ_signaling 566..655 CDD:238492 25/88 (28%)
PDZ_signaling 742..820 CDD:238492 20/104 (19%)
SH3_DLG-like 862..922 CDD:212795 15/44 (34%)
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142
Takusan 130..212 CDD:282652
TPR_MLP1_2 231..353 CDD:285204 13/79 (16%)
COG1340 295..587 CDD:224259 70/377 (19%)
FliJ 310..449 CDD:304890 29/183 (16%)
BAR 417..601 CDD:299863 50/266 (19%)
PDZ_signaling 620..707 CDD:238492 26/88 (30%)
DegQ <702..771 CDD:223343 24/103 (23%)
PDZ_signaling 722..790 CDD:238492 23/83 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122 40/194 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306
PDZ 1347..1429 CDD:214570
dbPDZ_assoc 1427..1499 CDD:293216
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493
PDZ 1499..1582 CDD:214570
SH3_DLG5 1597..1659 CDD:212794
GuKc 1732..1908 CDD:214504
Guanylate_kin 1740..1907 CDD:279019
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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