DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and GUK1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_010742.1	Gene:	GUK1 / 852065	SGDID:	S000002862	Length:	187	Species:	Saccharomyces cerevisiae

Alignment Length:	169	Identity:	35/169 - (20%)
Similarity:	69/169 - (40%)	Gaps:	27/169 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 YGHMLSSTSMVRTP---DVESGYFEKSESDASRDEWEGPSSSSSGAARCRLLSGISGLSVSSSSR 212
            :|..:|||:  |||   :|..    |..:..|.||::....::......:......|.:|:|..:
Yeast    30 FGFSVSSTT--RTPRAGEVNG----KDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQ 88

  Fly   213 HSAEGLRMELSRFRTMIETLERESLE--KSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGS 275
            .|..|        :|.|..::.:.::  |:..||..:....|.|..:......:..|....|..:
Yeast    89 VSKSG--------KTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESIN 145

  Fly   276 ERGFWSTIFGQAGLAISQ-DEEERIA---DIQKAHRALE 310
            :|    ....||.||.:: ...:::.   |:.||::.|:
Yeast   146 KR----LSAAQAELAYAETGAHDKVIVNDDLDKAYKELK 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	3/8 (38%)
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492
		SH3_DLG-like	862..922	CDD:212795
GUK1	NP_010742.1	guanyl_kin	3..185	CDD:213788	35/169 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810