DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and CARD11

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001311210.1	Gene:	CARD11 / 84433	HGNCID:	16393	Length:	1154	Species:	Homo sapiens

Alignment Length:	917	Identity:	178/917 - (19%)
Similarity:	298/917 - (32%)	Gaps:	293/917 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ESGYFEKSESDASRDEW-EGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIE 230
            |..|..|.|.|:..||. :....:.:.|.|...||....::|..|     ..|::|:.:.:..:.
Human   178 ERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRS-----RDLQLEIDQLKHRLN 237

  Fly   231 TLERE-SLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWSTIFGQAGLAISQD 294
            .:|.| .||::||   ||.|:..:.:|| :..|.:...|:...:...:...|.|  |||.....|
Human   238 KMEEECKLERNQS---LKLKNDIENRPK-KEQVLELERENEMLKTKNQELQSII--QAGKRSLPD 296

  Fly   295 EEERIADI-----------------------QKAHRALELLEDYHARLSEPQDRALRIA-IERVI 335
            .::.|.||                       ::|.:|.||.:.|   |.|.:|..|:.: :.:..
Human   297 SDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKY---LEEKEDLELKCSTLGKDC 358

  Fly   336 RIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIAD----NQRMRIE 396
            .::|.|:...:|.::   |:....|.....:..|:|.......|||....:|.:    |..||||
Human   359 EMYKHRMNTVMLQLE---EVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIE 420

  Fly   397 SDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQ--------QQQGSKS-RSGSQTVNGDDSWLY 452
            .   ..:|..:...:.:.:...:.|.:..|..|:        |..|..| |:..|  ..|||...
Human   421 M---VRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQ--EADDSSTS 480

  Fly   453 ED----------------------IQLERGNSGLG------FSIAGGTDNPHIGTDTSIYITKLI 489
            |:                      |||:|..|.:.      |...|..:.   |||.|
Human   481 EESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEE---GTDAS------- 535

  Fly   490 SGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRG-----TATTPAA 549
                                          .|:..:|....:..|:...|.|.     ||..|..
Human   536 ------------------------------PSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGN 570

  Fly   550 GSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRL 614
            .|.....::.|.....|.|                         ||.       .||...:|
Human   571 DSIVRRYKEDAPHRSTVEE-------------------------DND-------SGGFDALD--- 600

  Fly   615 SIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQL 679
                             |::.:||                                       :.
Human   601 -----------------LDDDSHE---------------------------------------RY 609

  Fly   680 SQSQSQLATSQSQSQ-----VHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDIT 739
            |...|.:.:|.|..|     .:..:....|....|.|...|.:.|:|.....||.    |.:..|
Human   610 SFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGP----SVQHTT 670

  Fly   740 REPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSV--------NNV 796
            ....::|.|       ..::|| :.:|.:|..:..|..|:... |:.|.|||.:        .:|
Human   671 LNGDSLTSQ-------LTLLGG-NARGSFVHSVKPGSLAEKAG-LREGHQLLLLEGCIRGERQSV 726

  Fly   797 NLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSL 861
            .|...|.|||...::...|.|||..:...|.|.:....:::            |.:   |...|.
Human   727 PLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMED------------GLI---TSGDSF 776

  Fly   862 YVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNA---SDDEWWQARRVLGDNEDEQIGIVPSKRR 923
            |:|    .:.|....|.:..:..|..|::||.:.   ...||..||.....:.|..:|.:||..|
Human   777 YIR----LNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSR 837

  Fly   924 WERKMRARDRSVKFQG---------HA--AANNNLDKQ---STLDRK------KKNFTFSRKFPF 968
            .::.:..:.:.:..:|         |.  |..|.|..:   ||.|.:      :.:|.|.:...|
Human   838 AQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQF 902

  Fly   969 MKSRDEK 975
            :...:.|
Human   903 VSRSENK 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	13/56 (23%)
		PDZ	454..540	CDD:214570	14/113 (12%)
		PDZ_signaling	566..655	CDD:238492	10/88 (11%)
		PDZ_signaling	742..820	CDD:238492	22/85 (26%)
		SH3_DLG-like	862..922	CDD:212795	16/62 (26%)
CARD11	NP_001311210.1	CARD_CARD11_CARMA1	22..107	CDD:260070
		Linker. /evidence=ECO:0000305\|PubMed:31296852	111..128
		BAR	<173..>257	CDD:299863	24/86 (28%)
		GBP_C	<252..418	CDD:303769	36/174 (21%)
		coiled coil	387..398	CDD:293879	2/10 (20%)
		coiled coil	407..418	CDD:293879	2/10 (20%)
		Inhibitory domain (ID). /evidence=ECO:0000303\|PubMed:31296852	450..666		54/352 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..626		45/298 (15%)
		PDZ_signaling	680..752	CDD:238492	21/73 (29%)
		SH3	777..839	CDD:302595	17/65 (26%)
		NK	<1009..1143	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810