DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dlg1 and dlg5

DIOPT Version :9

Sequence 1:NP_001162718.1 Gene:dlg1 / 32083 FlyBaseID:FBgn0001624 Length:1030 Species:Drosophila melanogaster
Sequence 2:XP_004916076.1 Gene:dlg5 / 779611 XenbaseID:XB-GENE-978275 Length:1971 Species:Xenopus tropicalis


Alignment Length:1796 Identity:297/1796 - (16%)
Similarity:507/1796 - (28%) Gaps:887/1796 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDSDTDSE---------REKSSDPN------------EGLLSSDDKTFHDDDEPAED---SSPAD 41
            |.||::|.         .:.||.|.            |.:||...:...:.||..:.   |||..
 Frog   109 MPSDSESSGSLSSIGTTNKPSSPPPTAADSLQVNEKIETILSQLRQVTRERDELRKRLALSSPGS 173

  Fly    42 DEEEPEEEECLLPQ-KKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDM---- 101
            ..::......|.|. ::.:::|.:....|..|....|:|::..:|         |||.:|.    
 Frog   174 TFDDCRSSPKLTPDYERLKVQCMKAMSELEALQSQHAKALKKCEE---------AAKEADFYHAL 229

  Fly   102 -------------DGDS-----------------------------QLEVME--HQMETVTEPDP 122
                         |.:|                             |||:.|  .|.:.|.:.:.
 Frog   230 HSRMLSDHTQLQEDSESMRRNHAQLQREFSHLQQSCQDLKHLHETDQLEMSELRRQQQLVVKQNG 294

  Fly   123 EPPKCPTSLRDSVRESVECFYSAQDLL--EYGHMLSSTSMVRTPDVESGYFEKSESD--ASRDEW 183
            . .:....|.::..:.:|......|.|  :|...:||.::      :.|..|:||.:  :.:.:.
 Frog   295 S-SELINKLYNTALDKLEGVKKDYDSLRRQYNEKVSSHNL------DLGRLEQSEEEKRSLQKQL 352

  Fly   184 EGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIETLERESLEKSQSE----- 243
            ||.......|        |......|||....:.::.||::.....:.|:|| :|:.|:|     
 Frog   353 EGLLKQRENA--------IHFQHQFSSSMRRYDSIQQELNKVTLQNKELQRE-MERLQAEATRFK 408

  Fly   244 -LQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWSTIFGQAGLAISQDEEERIADIQKAHR 307
             :||||..:|:...::|                     .::|.:..|.:| :.::.|.::.|...
 Frog   409 TMQLKASKEAEKYKEER---------------------DSVFNEYRLIMS-ERDQVIKEMDKMQT 451

  Fly   308 ALELLE------DYHARLSEPQDRALR-----IAIERVIRIF-------------------KSRL 342
            .|||.:      ....|::..:..|||     ..:||...||                   :..|
 Frog   452 ELELAQGRLKNTSSEKRVASEEMEALRQELNSALVERDRSIFERNELLEKYCHEVKDKAEAQKEL 516

  Fly   343 FQALLDIQ-------------------------EFYELTLLDDSKSIQQKTA------------- 369
            .||..||:                         |:|:...:.||.::..:.|             
 Frog   517 DQACKDIETVKEERDVARKERTEAIIQRDHLLREYYQARQIQDSATLDMERANKEIEVLRKQYEA 581

  Fly   370 --ETLQIATK----------W---EKD-----GQAVK-IADN---QRMRIESDTENAKEPTVEQQ 410
              ..|:.||:          |   |:|     .:::: :.||   :|.|..|:...|.....:.:
 Frog   582 MSHELKEATQEAEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRAVSELAEALRNLDDMR 646

  Fly   411 QKQQQAQQRSSRSPQQQNPQQQQGSKSR------SGSQTVNGDD-SWLYEDIQLERGN-----SG 463
            :::..|.:......::.:.|.::.::.|      |....::.|. .|..|.::.||..     ..
 Frog   647 KQKNDASRELKELKEKMDNQMEKEARFRQLMAHSSHDSAIDTDSLEWETEVVEFERDREDMDLKA 711

  Fly   464 LGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKK 528
            |||.:|.|.:.|....::.|::||:..|  :.|||||.:||.::.:|||.:.:......:.|:..
 Frog   712 LGFDVADGVNEPLFPGESCIFVTKVDKG--SIADGRLRVNDCLLKINDVDLANKDRKQLLKAVLS 774

  Fly   529 AGNVVKLHVKRKR--GTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHI 591
            .|.|:.:.::|::  |...........|..:||                   |.|:         
 Frog   775 GGEVINMVIRRRKSLGNRIITPLHIHLGSQKDS-------------------GISL--------- 811

  Fly   592 PGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAV--------------------------------- 623
              ::|:.|:.::.|..|..:|.|..||:::.:                                 
 Frog   812 --ESGVLVSAVVPGSPAAKEGSLVAGDRVVTINGISLDNKSVMECEALLRNCQESLNLSLLKVVP 874

  Fly   624 ---------------------------------------------------------RTNGSEKN 631
                                                                     || |||:.
 Frog   875 PNTSWSGQNLFENLKESCHVLSPNIHAQNKRNLKNNSSTQTDIFNPDILECKKNMGDRT-GSERA 938

  Fly   632 LENVTH---ELAVATL------------------------------------------------- 644
            |:...|   |.::::|                                                 
 Frog   939 LQLSCHSHSEHSLSSLGGEVFMGQGYDILDDGGHPLGFADTMEDNLVETATGKRSSGTWPKVMVS 1003

  Fly   645 -----------------KSITDKVTL----------------IIG-------------------- 656
                             |||.|..|.                ::|                    
 Frog  1004 PGHSQGEFTVFKKPRHRKSIFDPDTFKRPQTPPKISFLPPVQVLGHSPQPSKTERPPTPPTPPKR 1068

  Fly   657 ------KTQHLTTSAS------------------------------------------------- 666
                  |.:|.::|||                                                 
 Frog  1069 SDSIKFKHRHQSSSASDSTVTAGSPPTSPSPGPLPAETSHKAHHSRAIGSCCREDGIDCPLTGCI 1133

  Fly   667 GGG-------------------------------------------------------------- 669
            |.|                                                              
 Frog  1134 GTGDVEGCLQRAEEPELKRARPRSAPALRHRLAPVLIPHYALQKFSMNSEERLSPELAHDWIRFS 1198

  Fly   670 ----------------GGGLSSGQQLSQSQSQLATS--------------------QSQSQVHQQ 698
                            |.|:|.....|.:.....|:                    .|.:|:.||
 Frog  1199 PTRSPRHSDIFAASMYGPGMSGTVPRSLAPCPAVTAVLRNPIYTAWSHRVPSNNCPSSANQICQQ 1263

  Fly   699 ------QH--------------------------------ATPMVNSQSTE----PGS-RYASTN 720
                  ||                                ::..:.|..||    |.: ||..::
 Frog  1264 HLHSSAQHHGRLSLDLSNKHPNEFCDTSRSRVPHGSNSLPSSARLGSSRTERIKIPSTPRYPRSS 1328

  Fly   721 V---------------LAAVPPGTPRAVSTED-------------------------------IT 739
            |               ..|.||.:|..:.|..                               :.
 Frog  1329 VGSDRGSLSHSECSSPSLASPPHSPLNLETSSFASSQSQSSVASLPRISVSTVPIGERRKDRPLV 1393

  Fly   740 REPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHE 804
            .|||.:.:|||.:.||.:|.|||.| ||:||.:..|..|.... |:.|||||..|.:||.:||.:
 Frog  1394 EEPRHVKVQKGSEPLGISIGGGESG-GIFVSKVTTGSIAQQAG-LEYGDQLLEFNGINLRNATEQ 1456

  Fly   805 EAAQALKTSGGVVTLLAQYRPEE----YNRFEARI------------------------------ 835
            :|...:......:|:||||.|..    ::|..:|:                              
 Frog  1457 QARLIIGQQCDTITILAQYNPNMCQHIHSRSSSRLDTSTTHSTPHSSGAATPDNHSIIDTVSEQD 1521

  Fly   836 -------------------------------QEL------KQQAALG---AGGS----------- 849
                                           .||      |....||   .||:           
 Frog  1522 EGTMTPPSKESTPSTSPCSSLRTNAEGIKRHSELRVVTLSKSPEKLGIQICGGNLHGIFVLDIEE 1586

  Fly   850 ----GTLL---------------RTTQKRSL-------------------------------YVR 864
                |.||               ||.::..|                               |:|
 Frog  1587 ENVVGGLLKGDMVLEYGSVDMRNRTAEEAYLEMLKPAENIKVKVQQKIDEFNKLKDLPGDGFYIR 1651

  Fly   865 ALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDD--------EW--WQARRVLGDNEDE-QIGIV 918
            ||:|    |...|||. |.||..|||:|    ||        .|  ||    |.:|..: |.|.|
 Frog  1652 ALYD----RQAELPSE-LSFKKDDILYV----DDTLPQGTFGTWMAWQ----LDENAQKLQRGQV 1703

  Fly   919 PSKRRWERKMRARDRSVKFQGHAAANNNLD---KQSTLDRKKKNFTFSRKFPFMKSRDEKNEDG- 979
            |||...|::...|....:.:....|:..|.   ::|...||.|:....       |||.|:..| 
 Frog  1704 PSKYMMEQEFSRRLSMSEGRDETMASKTLSAAARRSFFRRKNKHKRSG-------SRDGKDLQGL 1761

  Fly   980 ----SDQEPFMLCYTQDDANAEGGEIIYRVELPDMEQITLI 1016
                :|..||:     |::.:...:.:.||:......:.::
 Frog  1762 DTISTDSIPFL-----DESVSLAYQRVQRVDCTSPRPVLIL 1797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dlg1NP_001162718.1 L27_1 303..359 CDD:286187 19/110 (17%)
PDZ 454..540 CDD:214570 25/90 (28%)
PDZ_signaling 566..655 CDD:238492 24/263 (9%)
PDZ_signaling 742..820 CDD:238492 31/77 (40%)
SH3_DLG-like 862..922 CDD:212795 28/70 (40%)
dlg5XP_004916076.1 CARD 9..88 CDD:260018
Takusan 127..213 CDD:368141 17/85 (20%)
Smc <136..544 CDD:224117 81/454 (18%)
COG4372 443..>672 CDD:226809 37/228 (16%)
PDZ_signaling 697..784 CDD:238492 25/88 (28%)
PDZ_signaling 798..867 CDD:238492 13/98 (13%)
PDZ 1395..1477 CDD:214570 36/83 (43%)
dbPDZ_assoc 1475..1554 CDD:374667 4/78 (5%)
PDZ 1554..1633 CDD:214570 13/78 (17%)
SH3_DLG5 1649..1711 CDD:212794 29/74 (39%)
GuKc 1784..1960 CDD:214504 2/14 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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