DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and dlg1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_031757617.1	Gene:	dlg1 / 733937	XenbaseID:	XB-GENE-1016132	Length:	939	Species:	Xenopus tropicalis

Alignment Length:	811	Identity:	356/811 - (43%)
Similarity:	470/811 - (57%)	Gaps:	146/811 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 QKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQ- 366
            |...|||.|||:|..:|.:.:|:.||.:|||||.||:|.|||||:|||||||:||||:.||...
Frog     6 QDTQRALTLLEEYRCKLHQTEDKQLRKSIERVIGIFQSNLFQALIDIQEFYEVTLLDNPKSSDNA 70

  Fly   367 KTAETLQIATKWEKDG-----------QAVKIADNQRMRIESDTENAKEPT-------------- 406
            |..|.:|....||...           .:..|.:.::.|...|...::||:
Frog    71 KPTEPVQTINTWEYSSLPNSTATCETLPSSLILNVEKYRYPDDDITSQEPSSPHMLNDGRNVELV 135

  Fly   407 ------VEQQQKQQQAQQRSSRSP---------------------------------QQQNPQQQ 432
                  :.|::..|.....|..||                                 .|.||...
Frog   136 QISEKNISQKENIQGLVSHSLISPLKTPEADTPCPPIVPVIPVIPVPAESNVIPSSTPQANPPPV 200

  Fly   433 QGSKSRSGSQTVNGDDS-WLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAA 496
            ..:........|||.|: :.||:|.||||.|||||||||||||||||.|.||:|||:|||||||.
Frog   201 IVNTDLETPAYVNGTDAEYEYEEITLERGTSGLGFSIAGGTDNPHIGDDISIFITKIISGGAAAQ 265

  Fly   497 DGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAA 561
            ||||.:||.|:.||:|.|.||.|:.||:|||:||::|:|:|:|::...
Frog   266 DGRLRVNDCILRVNEVDVHDVTHSKAVEALKEAGSIVRLYVRRRKPVT----------------- 313

  Fly   562 SGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTN 626
              .|:::|.||||.||||||||||:|||||||||.|||||:::||||..||||.|||||:||.|
Frog   314 --EKIMDIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKLLAVNT- 375

  Fly   627 GSEKNLENVTHELAVATLKSITDKVTLIIGK--TQHLTTSASGGGGGGLSSGQQLSQSQSQLATS 689
               ..||.|:||.||..||:.:|.|.|.:.|  |.::..                :.:...:..|
Frog   376 ---VCLEEVSHEDAVTALKNTSDFVNLKVAKPTTMYMND----------------NYAPPDITNS 421

  Fly   690 QSQSQVHQQQHATP---MVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGP 751
            .|| ||  ..|.:|   :.:.....|| ||:         |.....:..:|:|||||.:.:|:|.
Frog   422 YSQ-QV--DNHISPSGFIGHPLPPSPG-RYS---------PAPKGMLEDDDLTREPRKVVLQRGT 473

  Fly   752 QGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGV 816
            .||||||||||||:||::|||||||||||..||::||:::|||.|:|..||||:||.|||.:|..
Frog   474 TGLGFNIVGGEDGEGIFISFILAGGPADLSGELQKGDRIMSVNGVDLKSATHEQAAAALKNAGQT 538

  Fly   817 VTLLAQYRPEEYNRFEARIQELKQQAALG--AGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPS 879
            ||::||||||||:||||:|.:|::|....  :.|||: |||:||||||||||||||..:|.||||
Frog   539 VTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGS-LRTSQKRSLYVRALFDYDKTKDSGLPS 602

  Fly   880 RGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAAN 944
            :||.||.||||||.|||||||||||:|..|.|.|:||::|||||.|:|.|||.::|||...|..:
Frog   603 QGLNFKFGDILHVVNASDDEWWQARQVTADGESEEIGVIPSKRRVEKKERARLKTVKFNSKARGD 667

  Fly   945 NNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGGEIIYRVELPD 1009
            ..   ||..|::|||. |||||||.|::|:...:.||.:..:      .:||...|..|.:.:.|
Frog   668 KG---QSFNDKRKKNL-FSRKFPFYKNKDQSEMETSDVDQHV------TSNASDSESSYLILITD 722

  Fly  1010 --------MEQITLIY--LENNDADYRKSSI 1030
                    .|:..|.|  :...:.:|.:..|
Frog   723 EYGCSQGGQEEYVLSYEPVNQQEVNYSRPVI 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	34/55 (62%)
		PDZ	454..540	CDD:214570	59/85 (69%)
		PDZ_signaling	566..655	CDD:238492	57/88 (65%)
		PDZ_signaling	742..820	CDD:238492	50/77 (65%)
		SH3_DLG-like	862..922	CDD:212795	43/59 (73%)
dlg1	XP_031757617.1	L27_1	2..62	CDD:401120	34/55 (62%)
		MAGUK_N_PEST	106..222	CDD:402306	64/169 (38%)
		PDZ_signaling	223..307	CDD:238492	41/83 (49%)
		PDZ_signaling	316..402	CDD:238492	29/87 (33%)
		PDZ_assoc	403..465	CDD:402299	23/64 (36%)
		PDZ	463..547	CDD:214570	54/83 (65%)
		SH3_DLG1	582..648	CDD:212964	42/65 (65%)
		Guanylate_kin	748..926	CDD:395500

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1362
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20869
Inparanoid	1	1.050	922	1.000	Inparanoid score	I358
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm47450
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3167
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110