DRSC/TRiP Functional Genomics Resources

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Protein Alignment dlg1 and PALS1

DIOPT Version :9

Sequence 1:NP_001162718.1 Gene:dlg1 / 32083 FlyBaseID:FBgn0001624 Length:1030 Species:Drosophila melanogaster
Sequence 2:NP_071919.2 Gene:PALS1 / 64398 HGNCID:18669 Length:675 Species:Homo sapiens


Alignment Length:638 Identity:121/638 - (18%)
Similarity:218/638 - (34%) Gaps:212/638 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 NQRMRIESDTE--NAKEPTVEQQQKQQQ-----------AQQRSSRSPQQQNPQQQQGSKSRSGS 441
            |..:..|||:|  |....:.|:.||.::           ......||.|.:..:|||        
Human     7 NGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQ-------- 63

  Fly   442 QTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDII 506
                       ||::..|...|         ....:..::|:.:.||                  
Human    64 -----------EDMRRRREEEG---------KKQELDLNSSMRLKKL------------------ 90

  Fly   507 VSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEI-D 570
                    ..:|..:.:|                     .|...:..|...:|.....|::|| |
Human    91 --------AQIPPKTGID---------------------NPMFDTEEGIVLESPHYAVKILEIED 126

  Fly   571 LVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENV 635
            |....|.:          ||          .|:|   :|....:|:   |:.:..|...:|...:
Human   127 LFSSLKHI----------QH----------TLVD---SQSQEDISL---LLQLVQNKDFQNAFKI 165

  Fly   636 THELAV------------ATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLAT 688
            .:.:.|            :..:.:..:|..::....|             ..||:|:   :.|.|
Human   166 HNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHH-------------KEGQELT---ALLNT 214

  Fly   689 SQSQSQV-------HQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTIT 746
            ...|:.:       .|:....|:.:.:..|...:|....|         :.|..|.....|...|
Human   215 PHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETV---------KIVRIEKARDIPLGAT 270

  Fly   747 IQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALK 811
            ::             .:...:.:|.|:.||.|:....|..||::|.:|.:.:......|....|.
Human   271 VR-------------NEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLS 322

  Fly   812 TSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDG 876
            ...|.:|.:.           ...|::|...|             ::..::|:|.|||||:.|..
Human   323 DMHGTLTFVL-----------IPSQQIKPPPA-------------KETVIHVKAHFDYDPSDDPY 363

  Fly   877 LPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQI-GIVPSKRRWERKMRARDRSVKFQ 938
            :|.|  ||.|:.||||||.:..|..||||.|. ||.:::.: |:||.| .::::..|..::::  
Human   364 VPCRELGLSFQKGDILHVISQEDPNWWQAYRE-GDEDNQPLAGLVPGK-SFQQQREAMKQTIE-- 424

  Fly   939 GHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQ 991
                .:...:|...|...|||....:|..:   ...||:|..::|  :|.|.:
Human   425 ----EDKEPEKSGKLWCAKKNKKKRKKVLY---NANKNDDYDNEE--ILTYEE 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dlg1NP_001162718.1 L27_1 303..359 CDD:286187
PDZ 454..540 CDD:214570 8/85 (9%)
PDZ_signaling 566..655 CDD:238492 16/101 (16%)
PDZ_signaling 742..820 CDD:238492 16/77 (21%)
SH3_DLG-like 862..922 CDD:212795 30/62 (48%)
PALS1NP_071919.2 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2 1..345 77/500 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 9/26 (35%)
Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2 21..140 30/213 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78 10/54 (19%)
L27_N 123..170 CDD:401122 14/72 (19%)
Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2 181..243 10/77 (13%)
L27 189..237 CDD:197794 9/63 (14%)
PDZ_signaling 254..333 CDD:238492 19/111 (17%)
SH3_MPP5 349..411 CDD:212969 31/63 (49%)
GuKc 491..661 CDD:214504
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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