DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and Mpp4

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_038940071.1	Gene:	Mpp4 / 58808	RGDID:	620016	Length:	636	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	83/340 - (24%)
Similarity:	136/340 - (40%)	Gaps:	59/340 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 QSQSQVHQQQHATPMVNSQST------EPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQ 748
            |...||.|..|...::.:..|      ||        :|..:|...|      |.....||:.:.
  Rat   139 QELRQVLQAPHCKALLRAHDTVAQKDFEP--------LLPPLPDNIP------DSEEAMRTVCLV 189

  Fly   749 KGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTS 813
            |..|.||..|...|....|.|:.::.||..:....|..||:|:.||.|.:.....|:....|..|
  Rat   190 KNQQPLGATIKRHEITGDILVARVIHGGLVERSGLLYAGDKLVEVNGVPVEGLDPEQVIHILAMS 254

  Fly   814 GGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLP 878
            .|  |::.:..|.                        :....:.:.::||||:.||.|..|..:|
  Rat   255 CG--TIMFKVIPV------------------------SAPPVSSQTTVYVRAMIDYWPQEDPDIP 293

  Fly   879 --SRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQI--GIVPSKRRWERKMRARDRSVKFQG 939
              ..||||..||||.:.:.||..|||||::    .|..|  |::||....:||.|....|..:|.
  Rat   294 CMDAGLPFLKGDILQIVDQSDALWWQARKI----SDLAICAGLIPSNHLLKRKQREFWWSQPYQP 354

  Fly   940 HAAANNNLDKQSTLDRKKKNFT--FSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGGEII 1002
            |....:...|:..:...::.|.  |.|.....:.:...::..::......||:...|..|  |::
  Rat   355 HTCLKSTRSKEEFVGDGQQFFIAGFRRSMRLCRRKSHFSQLHANMRCTCSCYSAVGAPYE--EVV 417

  Fly  1003 -YRVELPDMEQITLI 1016
             |:.:..|..::.::
  Rat   418 RYQRQPADKHRLIVL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	24/77 (31%)
		SH3_DLG-like	862..922	CDD:212795	29/63 (46%)
Mpp4	XP_038940071.1	L27	<79..114	CDD:197794
		L27	124..171	CDD:197794	9/39 (23%)
		PDZ_signaling	184..263	CDD:238492	24/80 (30%)
		SH3_MPP4	277..337	CDD:212967	29/63 (46%)
		Guanylate_kin	428..618	CDD:395500	0/5 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810