DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and mpp3a

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_021330373.1	Gene:	mpp3a / 572079	ZFINID:	ZDB-GENE-130530-555	Length:	613	Species:	Danio rerio

Alignment Length:	345	Identity:	88/345 - (25%)
Similarity:	135/345 - (39%)	Gaps:	92/345 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 GGGLSSGQQLSQSQSQLATSQSQSQV-----------------------HQQQHATPMVNSQST- 710
            ||||.....|..||.:...:..:..|                       :::|..||:::|.||
Zfish    11 GGGLHETLALLTSQLRPDANHKEDMVFLRDVFSERSLSCLMKIHEKLRQYEKQSPTPVLHSASTL 75

  Fly   711 --------EPG-------------------------SRYASTNVLAAVPPGTPRAVSTEDITREP 742
                    :.|                         ...|..|....:|| .|.....|......
Zfish    76 AEDVAEELQSGPMSVEEKELLHLLTSPHLKAVLSVHDTVAQKNFDPVLPP-LPDDFEDELDEESV 139

  Fly   743 RTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAA 807
            :.:.:.|..:.||..|...|....:.|:.|:.||.||....:..||:|..||..::.|...:|.:
Zfish   140 KIVRLVKNKEPLGATIRRDESTGAVIVARIMKGGAADRSGLVHVGDELREVNGSSVMHKRPDEIS 204

  Fly   808 QALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPN 872
            |.|..|.|.:||..             |..:|::..|            |:..:|:||||||.|.
Zfish   205 QLLSQSQGSITLKI-------------IPAIKEEDKL------------QENKVYMRALFDYTPL 244

  Fly   873 RDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSV 935
            .|...|.:  |||||.||:|.|.:..|..||||:|: ||. :.:.|:||||:..||::..|.:..
Zfish   245 EDKATPCQEAGLPFKRGDVLQVVSQDDQTWWQAKRI-GDC-NLRAGLVPSKQFQERRLAYRIKMG 307

  Fly   936 KFQGHAAANNNLDKQSTLDR 955
            ..|     |:...|::..|:
Zfish   308 TLQ-----NSKSPKKAVYDQ 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	23/77 (30%)
		SH3_DLG-like	862..922	CDD:212795	31/61 (51%)
mpp3a	XP_021330373.1	L27	15..66	CDD:308467	5/50 (10%)
		L27	73..123	CDD:308467	5/49 (10%)
		PDZ_signaling	139..219	CDD:238492	24/92 (26%)
		SH3	234..295	CDD:327375	32/62 (52%)
		GuKc	426..597	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810