DRSC/TRiP Functional Genomics Resources

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Protein Alignment dlg1 and dlg5a

DIOPT Version :9

Sequence 1:NP_001162718.1 Gene:dlg1 / 32083 FlyBaseID:FBgn0001624 Length:1030 Species:Drosophila melanogaster
Sequence 2:XP_005156738.1 Gene:dlg5a / 569065 ZFINID:ZDB-GENE-030131-3149 Length:1961 Species:Danio rerio


Alignment Length:1738 Identity:291/1738 - (16%)
Similarity:497/1738 - (28%) Gaps:836/1738 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 REKSSDPNEGLLSSDDKTFHDDDEPAEDSSPADDEEEPEEEECLLPQKKAQIRCDQDQPPLVVLV 73
            ||:........|:|...|| ||..|  :|.|..|.|            :.:.:|.:....|..|.
Zfish   156 RERDELRKRLALASPGTTF-DDCRP--NSKPGHDYE------------RLKTQCTKAMADLQSLQ 205

  Fly    74 QPSAEAIEVRQEIDDTNPVAVAAKASD---------MDGDSQLEVMEHQMETVTEPDPEPPKCPT 129
            ....:.::..:|         |.|.:|         :...:||   :.:||.:...:.:..:...
Zfish   206 NQHTKTLKRCEE---------AVKEADYYHIQHSRLLSEQTQL---KEEMEVLKRENTKLTREHN 258

  Fly   130 SLRDSVRESVECFYSAQDLLEYGHM-LSSTSMVRTPDVESGYFEKSES--DASRDEWEG------ 185
            .|:.|. |.:...:| :|..|...| |....::|    |:|..|....  |.:.|:.||      
Zfish   259 HLKQSC-EELRRLHS-EDQREVADMRLQQQQVIR----ENGSSEVLNKLYDTAMDKLEGVKKEYD 317

  Fly   186 ---------PSSSSSGAARC--------RLLSGISGLSVS-----------SSSRHSAEGLRMEL 222
                     .||.::..:|.        ||...|..|...           |:|....:.::.||
Zfish   318 VLSKRYSEKVSSHNTDLSRLEQVEEENRRLQKQIDALLKQRDTAIQYQQQWSTSMRRFDSVQQEL 382

  Fly   223 SRFRTMIETLERESLEKSQSEL------QLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWS 281
            ::.....:.|:|| :|:.|||:      ||||             |:|     |.:...||   .
Zfish   383 NKASAQNKELQRE-MERLQSEVTRYKNFQLKA-------------VKD-----GEKYKEER---D 425

  Fly   282 TIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSE------------------------P 322
            ::|.:..|.:| :.::.|.::.|....||..|   |||..                        .
Zfish   426 SVFNEYRLIMS-ERDQVIKEVDKLQTELEAAE---ARLKNTSSERMVASEELEALRQELNSSLVD 486

  Fly   323 QDRAL---RIAIERVIRIFKSR------LFQALLDIQ-------------------------EFY 353
            :|||:   ...:|:.....|.:      |.||..||:                         |:|
Zfish   487 RDRAICERNELLEKYCHEVKDKAEAQKELSQACKDIETVREERDVARKERTEAIIQRDQLLREYY 551

  Fly   354 ELTLLDDS-------------------KSIQQKTAETLQIA------TKW---EKD-----GQAV 385
            :.....||                   :::.|:..|.:|.|      ..|   |:|     .:::
Zfish   552 QARQKQDSATLDMERANKEIDILRKQCEAMSQELKEAVQEAEVAKCRRDWAFQERDKIVAERESI 616

  Fly   386 K-IADN---QRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSK-----SRSGS 441
            : :.||   :|.|..||..:|.....:.::::..|.:......::...|..:.::     :.|..
Zfish   617 RTLCDNLRRERDRAVSDLADALRNLDDMRKQRNDAARELKELKEKMESQLDKEARFCQLMAHSSH 681

  Fly   442 QTVNGDDS--WLYEDIQLERGN-----SGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGR 499
            .:....||  |..|.::.|:..     ..:||.||.|.::|::..|..|:::::..|  :.||||
Zfish   682 DSAIDTDSLEWETEVVEFEKDRDDMDLKAMGFDIAEGVNDPYLPGDCGIFVSRVDKG--SIADGR 744

  Fly   500 LSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGP 564
            |.:||.::.:|||.:.:......:.|:...|.::.:.|:|::         |..|....|     
Zfish   745 LRVNDWLLKINDVDLTNKDRKQVIKAVLNGGGLINMVVRRRK---------SLGGRLVTS----- 795

  Fly   565 KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAV------ 623
              :.|:|: |.|..|.::.|           |::|..:..|..|..:|.|:|||:|||:      
Zfish   796 --VHINLI-GHKDAGIALEG-----------GVFVAGIAPGSPAAREGSLTIGDRLIAINGIALD 846

  Fly   624 -------------------------------------------RTNG-------SEKNLENVTHE 638
                                                       ::||       ..:|..|:.|.
Zfish   847 NKSLSECEALLRGGRDSLALSLMKFFPQSTSGQNIFESLREAEKSNGRIHLTDVHSRNSRNLKHN 911

  Fly   639 ---------------------------------LAVATL-------------------------- 644
                                             ..::||                          
Zfish   912 SSTQTDIYSCDTAGERRKTRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASAFQEVCY 976

  Fly   645 --------KSITDKVTL------------IIG--------------------------------- 656
                    :.:|.:.||            ::|                                 
Zfish   977 TRSESVGPECVTLETTLEKKHSGGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIFDADTFKRPD 1041

  Fly   657 -----------------------------------KTQHLTTSAS--------------GGGGGG 672
                                               |.|..:||.|              ..|...
Zfish  1042 TPSKADYHGPQPLKADSAPTPPTPPTRSDSFKFKHKHQGSSTSESTISAMSISEPKQEDRNGNLY 1106

  Fly   673 LSSGQQLSQSQS-----------------------------------QLATSQSQS--------- 693
            .|.|:.||..:|                                   .|.:.||.|         
Zfish  1107 FSEGKVLSSRKSCEEDIGRMWAEEPEVKRPRPKSAPALRRRMTPQNIPLQSFQSYSNDGDSVEQR 1171

  Fly   694 -------------------------------------------------------QVH------- 696
                                                                   :||       
Zfish  1172 EMLRSSPNRPHRHSVGFVPTSYNGTLPPNSAHRGLAPCSAVTAVMKNPVYMVRSHRVHTNNCPTV 1236

  Fly   697 ----QQQHATP-----------MVNSQSTE-----------------PGS-RYASTNVL-----A 723
                .|||..|           :...:||:                 |.| |..|:|.|     .
Zfish  1237 VSQINQQHTHPSPQHQGQLSLDLSQKRSTDYSESSRSSRASHGTNSLPSSARLGSSNNLQYRTER 1301

  Fly   724 AVPPGTPR--------------------------------------------------------A 732
            ...|.|||                                                        .
Zfish  1302 IKIPSTPRYPRSILGSDRGSLSHSECSSPSLITPPLSPLNLETSSFASSQSQGSISTLPRISVSP 1366

  Fly   733 VSTED------ITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLL 791
            |.||:      ...|||.:.:.||.:.||.:||.||:| ||:||.:..|..|.... |:.|||||
Zfish  1367 VPTEERRKDRPYLEEPRNVMVHKGAEPLGISIVSGENG-GIFVSKVTGGSIAHQAG-LEYGDQLL 1429

  Fly   792 SVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEY-----NRFEARIQELKQQAALGAGGS-- 849
            ..|.:||.:||.::|...:......:|::|||.|..|     :|..:|::.:..|:.....|:  
Zfish  1430 EYNGINLRNATEQQARLIIGQQCDTITIMAQYNPHMYQLGNHSRSSSRLEPVSTQSTPQGSGTAT 1494

  Fly   850 ---------------GTL----------------------------------LRTTQ-------- 857
                           |||                                  :|.||        
Zfish  1495 PDNHSTIDTLSEQDEGTLTPSSKQTTPTTSPNSFIRMPSESSKKVPEARLVTVRKTQVELGIQLC 1559

  Fly   858 ---KRSLYVRALFDYDP------------------------------------------------ 871
               .|.::|..|.|..|                                                
Zfish  1560 GGNLRGIFVERLEDDSPARGADAVVPGDMILEYGSVNMKNKTVEEAYLEMLKPAETVTLRVQHRL 1624

  Fly   872 ---NRDDGLPSRG----------------LPFKHGDILHV----TNASDDEW--WQARRVLGDNE 911
               |:..|.|..|                |.||..|||:|    .|.:...|  ||    |.:|.
Zfish  1625 DEFNQVKGTPGDGFYIRALYDRVAETELDLSFKKDDILYVDDTLPNGNFGTWMAWQ----LDENA 1685

  Fly   912 DE-QIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEK 975
            .: |.|.:|||...:::...|....:.:....::..|...:     :::| |.||....:|..:.
Zfish  1686 QKIQRGQIPSKFMMDQEFYRRHSMTELKDETGSSKTLSAAA-----RRSF-FRRKHKHKRSSSKD 1744

  Fly   976 NED-------GSDQEPFMLCYTQDDANAEGGEIIYRVELPDMEQITLI 1016
            .:|       .:|..||:     ||..:...:.:.:::......:.::
Zfish  1745 GKDVVALDAISTDSIPFL-----DDCVSLAYQRVQKIDCTSPRPVLIL 1787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dlg1NP_001162718.1 L27_1 303..359 CDD:286187 19/113 (17%)
PDZ 454..540 CDD:214570 23/90 (26%)
PDZ_signaling 566..655 CDD:238492 28/223 (13%)
PDZ_signaling 742..820 CDD:238492 30/77 (39%)
SH3_DLG-like 862..922 CDD:212795 25/133 (19%)
dlg5aXP_005156738.1 CARD 9..88 CDD:260018
Takusan 128..211 CDD:282652 16/69 (23%)
Taxilin 295..627 CDD:286771 66/357 (18%)
RILP-like 338..460 CDD:304877 34/147 (23%)
SH3BP5 444..648 CDD:283045 35/206 (17%)
PDZ_signaling 696..783 CDD:238492 22/88 (25%)
PDZ_signaling 793..866 CDD:238492 19/91 (21%)
PDZ 1381..1463 CDD:214570 34/83 (41%)
dbPDZ_assoc 1461..1541 CDD:293216 10/79 (13%)
PDZ 1541..1623 CDD:214570 8/81 (10%)
SH3_DLG5 1639..1701 CDD:212794 18/65 (28%)
Guanylate_kin 1780..1949 CDD:279019 0/8 (0%)
NK 1794..1950 CDD:302627
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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