DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and Pals2

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001158205.1	Gene:	Pals2 / 56524	MGIID:	1927340	Length:	553	Species:	Mus musculus

Alignment Length:	430	Identity:	101/430 - (23%)
Similarity:	151/430 - (35%)	Gaps:	126/430 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 IPGDNG------IYVTKLMDG----GAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELA-VATL 644
            :|...|      |::..:|:.    ..|:...||. ..||.||    |:.|||.|...|. :..|
Mouse    11 LPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLE-DSKLEAV----SDNNLELVNEILEDITPL 70

  Fly   645 KSITDKVTLIIG--KTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNS 707
            .|:.:.|..::|  |..|.               |.|.::...:|:....|.....:...|.:|:
Mouse    71 ISVDENVAELVGILKEPHF---------------QSLLEAHDIVASKCYDSPPSSPEMNIPSLNN 120

  Fly   708 QSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFI 772
            |......|....:..|..|.|....|...|:.                             ::.|
Mouse   121 QLPVDAIRILGIHKKAGEPLGVTFRVENNDLV-----------------------------IARI 156

  Fly   773 LAGGPADLGSELKRGDQLLSVNNVNLTHATHE------EAAQALKTSGGVVTL--LAQYR----P 825
            |.||..|....|..||.:..||.       ||      |..:.||...|.|||  |..||    |
Mouse   157 LHGGMIDRQGLLHVGDIIKEVNG-------HEVGNNPKELQELLKNISGSVTLKILPSYRDTITP 214

  Fly   826 EE-YNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSR--GLPFKHG 887
            :: |...|.....::|                    ::|:..|||:|..|:.:|.:  ||.|..|
Mouse   215 QQSYVNMERHPAHVRQ--------------------VFVKCHFDYNPFNDNLIPCKEAGLKFSKG 259

  Fly   888 DILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERK----MRARDRSVKFQGHAAANNNLD 948
            :||.:.|..|..||||..|   .|....|::||:...|::    .|..|.|..|.|
Mouse   260 EILQIVNREDPNWWQASHV---KEGGSAGLIPSQFLEEKRKAFVRRDWDNSGPFCG--------- 312

  Fly   949 KQSTLDRKKKN---FTFSRKFPFMKSRDEKNEDGSDQEPF 985
               |:..|||.   :..:|...|.:...:..|:.:...||
Mouse   313 ---TISNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPF 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492	20/74 (27%)
		PDZ_signaling	742..820	CDD:238492	19/85 (22%)
		SH3_DLG-like	862..922	CDD:212795	24/61 (39%)
Pals2	NP_001158205.1	L27	2..55	CDD:197794	12/48 (25%)
		L27	57..108	CDD:397114	14/65 (22%)
		PDZ_signaling	132..205	CDD:238492	24/108 (22%)
		SH3_MPP6	232..292	CDD:212971	24/62 (39%)
		Guanylate_kin	350..540	CDD:395500	101/430 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810