DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and LOC564220

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_017212193.1	Gene:	LOC564220 / 564220	-ID:	-	Length:	1406	Species:	Danio rerio

Alignment Length:	1116	Identity:	221/1116 - (19%)
Similarity:	379/1116 - (33%)	Gaps:	340/1116 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSPADDEEEPEEEECLLP------------------QKKAQIRCDQDQPPLVVLVQPSAEAIEVR 83
            |.|.||..||      ||                  ..|:....|   |.||...:|..:..:..
Zfish   282 SLPRDDSLEP------LPYNWEMAYTETGMVYFIDHNTKSTTWLD---PRLVKKAKPPEKCEDGE 337

  Fly    84 -----QEIDD-----------------TNPVAVAAKASDMDGDSQLEVMEHQMETVTEPDPEPPK 126
                 :||||                 .|||..|.:...:|         ..:.|.|:....||.
Zfish   338 LPYGWEEIDDPQYGTYYVDHINQRTQFENPVVEAKRKLGLD---------TAVATQTQQRAAPPP 393

  Fly   127 -----CPTSLRDSVRESVECFYSAQDLLEYGHMLS------STSMVRTPDVESGYFEKSESDASR 180
                 .|...||..:...|.:::|....:.|...:      |...::..:|.|
Zfish   394 GGAAGTPGFTRDPTQLKGELYHTALRKSQQGFGFTIIGGDRSDEFLQVKNVLS------------ 446

  Fly   181 DEWEGPSSSSSGAARCRLLSGISGLSVSSSSRHSA----------EGLRMELSRFRTMIETLERE 235
               :||::..:..|...::..|:|..|...:....          :.:.|.|.|..::...::.:
Zfish   447 ---DGPAAQDNKMASGDVIVEINGTLVLGKTHADVVHMFQCIPINQYVDMVLCRGYSLPPDVDAD 508

  Fly   236 SLE------KSQSEL----------QLKAKSKAKPKPKQRSH--VQDAAG---------ESGSEQ 273
            |.:      ....|:          .|..|..|.....|..|  ..||:|         .|.:..
Zfish   509 SEDLPPPPPPPTGEIVTAVPLINGQPLLVKGDALHGSSQELHYVTTDASGRPVVAALPASSAAND 573

  Fly   274 GSERGFWS-------TIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSEPQDRALRIAI 331
            ..|.|...       .:.|..|...:      |||.....:...:|::...|.....|....|..
Zfish   574 RPETGMLQPELVSVPIVKGPGGFGFA------IADCPLGQKVKMILDEQWCRGLLKGDVIKEINR 632

  Fly   332 ERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIE 396
            :.|..:..:::...|.|:....|:.||      ..:..:|..:.:...:.|.
Zfish   633 QNVQTLSHAQVVDILKDLPVGSEVNLL------VLRGGQTSPVKSLRPRGGM------------- 678

  Fly   397 SDTENAKEPTVEQ--QQKQQQAQQRSSRSPQQQNPQQQQG---SKSRSGSQTVNGDDSWLYEDIQ 456
                :|...|:::  .....||....|.:....:|:|...   ||.::.::::......|  |:.
Zfish   679 ----SASTETLDRCHDMMVPQALTYHSNTLPCSSPKQDASLHYSKPKALTESIVPQYKEL--DVF 737

  Fly   457 LERG-NSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHA 520
            ::|. .:|.||.:.||.     |.:..:||..:|..|||..:|||...|.::.::.::|....|.
Zfish   738 IKRDQETGFGFRVLGGE-----GAEQPVYIGAIIPQGAAEKEGRLRAGDELIGIDGITVKGKSHK 797

  Fly   521 SAVDALKKA---GNVVKLHVKRKRGTATTPAAGSAAGDARDSAASG--------PKV--IEIDLV 572
            ..:|.:..|   |.|: |.|:||          ....||.:...||        |::  |::..|
Zfish   798 QVLDLMTNAARNGQVL-LSVRRK----------VIFRDALEDVGSGALTLVNGSPRLPRIQVPSV 851

  Fly   573 K------------GGKGLGFSI-------AGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGD 618
            |            ..:|.||.|       ..|:....||...|    ::::|......|.|::||
Zfish   852 KDQESFDITLHRRDNEGFGFVILTSKSKPPPGVCVSVIPHKIG----RIIEGSPTDRCGLLNVGD 912

  Fly   619 KLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQ---LS 680
            ::.||    :.:::..::|...|..:|...:.|||.:..........||......|...|   |.
Zfish   913 RISAV----NSQSIVELSHNDIVQLIKDAGNSVTLTVVPEDEYKGPPSGASSAKQSPAPQHKTLK 973

  Fly   681 QSQSQ---LATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREP 742
            .:|.:   |...:.:.::...::.||  |.|.::.|                  .::.|
Zfish   974 STQDERYNLDMDEIRDELTWTEYKTP--NRQESKQG------------------CIAVE------ 1012

  Fly   743 RTITIQKGPQGLGFNIVGG-EDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEA 806
                :::||:|.||::.|| |...|:|:..:...|||.....:..|||::.:|.......:|..|
Zfish  1013 ----LERGPRGFGFSLRGGTEYNMGLYILRLAEDGPALQDGRIHVGDQVVEINGEQTQGISHTRA 1073

  Fly   807 AQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAAL----GAG--------GSGT-------- 851
            .:.::..|..|.||                 |:.||.|    .||        ||.|
Zfish  1074 IELIQAGGNKVLLL-----------------LRPQALLPENSSAGDVILPDPPGSHTSNIPLSSH 1121

  Fly   852 -LLRTTQKRSLYVRALFD--YDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRV------- 906
             ...:.:||:    .|.|  .:|::|....      ||....:.:::...:  |.||:
Zfish  1122 PTSTSVKKRT----GLTDGSLNPSKDSKRE------KHTKTPNTSSSRVSQ--QPRRIKSRSAEN 1174

  Fly   907 ---LGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFT--FSRKF 966
               |||.|..:   .|||    .|.:|.....|.|           |||.|.:|...:  .||..
Zfish  1175 LLDLGDTEKSK---SPSK----AKDKAHSHKEKLQ-----------QSTRDSQKNRSSRQHSRSV 1221

  Fly   967 PFMKSRDEKNE 977
            ...|||.|:.|
Zfish  1222 SPQKSRRERQE 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	9/55 (16%)
		PDZ	454..540	CDD:214570	26/89 (29%)
		PDZ_signaling	566..655	CDD:238492	24/109 (22%)
		PDZ_signaling	742..820	CDD:238492	21/78 (27%)
		SH3_DLG-like	862..922	CDD:212795	15/71 (21%)
LOC564220	XP_017212193.1	PDZ_signaling	15..98	CDD:238492
		NK	120..>198	CDD:327404
		WW	291..323	CDD:197736	6/40 (15%)
		WW	338..367	CDD:306827	4/28 (14%)
		PDZ	412..498	CDD:214570	14/100 (14%)
		PDZ	589..664	CDD:214570	15/86 (17%)
		PDZ_signaling	733..817	CDD:238492	26/91 (29%)
		PDZ_signaling	857..946	CDD:238492	21/96 (22%)
		PDZ_signaling	1011..1084	CDD:238492	21/82 (26%)
		Neuromodulin_N	<1182..>1365	CDD:331332	20/69 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910