DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and mpp2a

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001314719.1	Gene:	mpp2a / 562207	ZFINID:	ZDB-GENE-071004-82	Length:	547	Species:	Danio rerio

Alignment Length:	414	Identity:	103/414 - (24%)
Similarity:	148/414 - (35%)	Gaps:	129/414 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 KLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQ 683
            :|.|||.|..|. ::::..||:..|.:|.|......|....|.                     |
Zfish    53 RLEAVRDNNVEL-VQDILRELSPFTHRSNTAAELSRILNQPHF---------------------Q 95

  Fly   684 SQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRA-----VSTEDITREP- 742
            |.|.|..|             |.||:.|.             ||.:|.|     :||..:..:.
Zfish    96 SLLETHDS-------------VASQTCES-------------PPPSPCAFMEPPISTAQVPADAI 134

  Fly   743 RTITIQKGP---QGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVN--NVNLTHAT 802
            |.:.|:|.|   .|:.|.|..||    :.::.||.||..|....|..||.:..||  .|......
Zfish   135 RMVGIRKVPGEHLGVTFRIENGE----LVIARILHGGMIDQQGLLHVGDIIKEVNGREVGDDPRV 195

  Fly   803 HEEAAQALKTSGGVV-TLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRAL 866
            .:|..|  :|||.:| .:|..|:...                             ..|.::|:..
Zfish   196 LQEVLQ--ETSGNIVLKILPSYQEPH-----------------------------PPRQVFVKCH 229

  Fly   867 FDYDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMR 929
            .||||..|:.:|.:  ||.|..||||.:.|..|..|||||.|.|.:    .|::||:...|::..
Zfish   230 CDYDPANDNLIPCKEAGLMFSSGDILQIVNQEDVNWWQARHVEGGS----AGLIPSQLLEEKRKA 290

  Fly   930 ARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDA 994
            ...|.|:....|    ||.......:|||          |.....||.|....|  :|.|.:
Zfish   291 FVKRDVELSPAA----NLCSGMVGKKKKK----------MMYLTTKNADFDRHE--LLIYEE--- 336

  Fly   995 NAEGGEIIYRVELPDMEQITLIYL 1018
                     ..::|...:.|||.:
Zfish   337 ---------VAKVPPFRRKTLILI 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492	11/35 (31%)
		PDZ_signaling	742..820	CDD:238492	26/84 (31%)
		SH3_DLG-like	862..922	CDD:212795	26/61 (43%)
mpp2a	NP_001314719.1	L27	62..113	CDD:308467	17/98 (17%)
		PDZ_signaling	134..212	CDD:238492	26/83 (31%)
		SH3	225..283	CDD:327375	26/61 (43%)
		Guanylate_kin	344..534	CDD:331880	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910