DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and card11

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_009297971.1	Gene:	card11 / 557072	ZFINID:	ZDB-GENE-100219-1	Length:	1125	Species:	Danio rerio

Alignment Length:	961	Identity:	175/961 - (18%)
Similarity:	329/961 - (34%)	Gaps:	299/961 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LLPQKKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMDGDSQLEVMEHQMET 116
            |:..|:...||.      .::|:...|.: ::..:::...:...:||.||          .:|:.
Zfish    99 LVTGKEPTRRCS------TIVVEEGQEGL-IQFLMNEVMKLQQQSKAKDM----------QRMDV 146

  Fly   117 VTEPDPEPPKCPTSLRDSVRESVECFYSAQDLLEYGHMLSSTSMVRTPDVESGYFEKSESDASRD 181
            :|       ||.| |.|   |..:...:.|:||.:....:..              |.|.:...|
Zfish   147 MT-------KCRT-LED---EHKKLRLTNQELLTFQERYNKM--------------KEERNNYND 186

  Fly   182 E-WEGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIETLERE-SLEKSQSEL 244
            | .:....:...|.|...||....::|..|     ..|::|:.:.:..:..:|.| .:|:.|| |
Zfish   187 ELMKVKDDNYQLAMRYAQLSEEKNMAVMRS-----RDLQLEIDQLKHKLNKVEEECKMERRQS-L 245

  Fly   245 QLKAKSKAKPKPKQ-----------RSHVQDAAG--ESGSEQGSERGFWSTI--FGQAGLAISQD 294
            :|:...:.:|:.:|           :..||:...  :.|....|::.....:  ..|..|...|:
Zfish   246 KLRNDIENRPRKEQVFELERENEVLKIKVQELQSIIQPGPLPDSDKAILDILEHDRQEALEDRQE 310

  Fly   295 EEERIADIQKAHRALELLEDYHARLSEPQDRALRIA-IERVIRIFKSRLFQALLDIQEFYELTLL 358
            ..:|:.::.:..|..|.|.|.:  |.|.:|..|:.: :.:...::|:|:...::.::|
Zfish   311 LVDRLCNLHEEVRQAEELRDKY--LEEKEDLELKCSTLVKDCEMYKNRMNTIMVQLEE------- 366

  Fly   359 DDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSRS 423
                             .:.|:| ||.|..|:.:..:       .:..:::.:.::|.::...:|
Zfish   367 -----------------VERERD-QAFKSRDDSQHLV-------SQCLIDKDKYRKQIRELEEKS 406

  Fly   424 PQQQNPQQQQGSK--------SRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTD 480
            .:.|....::.:|        .|...:  ||.|.      .|.||.:.|..:...|..:...|.|
Zfish   407 DELQIEIVRKEAKIVNLECKLRRMAKE--NGLDQ------SLPRGITPLIIAQNFGQHDEDSGED 463

  Fly   481 TSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTAT 545
            |                           |:||..          .|::..| :|..|.| .....
Zfish   464 T---------------------------VDDVEF----------RLQRRSN-LKGRVSR-INRPK 489

  Fly   546 TPAAGSAA----------GDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVT 600
            :||||..:          ||..:.||             |...|||.|..:   :.|.:  ::
Zfish   490 SPAAGPKSPLFPAQPFTNGDLSEHAA-------------GDSTGFSNASPM---NTPAE--LF-- 534

  Fly   601 KLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSA 665
                                        .||:.:..|.: ::|.....|..:::....::
Zfish   535 ----------------------------SKNIRSRNHSI-LSTAPEPPDNHSIVRRIKEN----- 565

  Fly   666 SGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAV----- 725
                    |.....|...|..|.:.|........|....:||.|:...|....:..|..|
Zfish   566 --------SDALHKSFLPSDTADTDSGDNADMDDHEPSSINSSSSSHQSEIMDSYDLEQVNNIFR 622

  Fly   726 ------------PPGTPR---------AVSTEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYV 769
                        ..|.||         ::|.|::..|              ..::||.| .||:|
Zfish   623 KFSLERPFRPSLTSGPPRNSLRTVQSLSLSGENLLSE--------------ITLIGGND-SGIFV 672

  Fly   770 SFILAGGPADLGSELKRGDQLL--------SVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPE 826
            :.:.:|..|||.. :|.|..||        ...:|:|..:|.|||...|:...|.|.|..:...:
Zfish   673 NSVQSGSDADLAG-VKVGFHLLMLEGNVHGKAESVSLDTSTKEEAHWTLQRCSGQVHLHYKSSYD 736

  Fly   827 EYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILH 891
            .|.|....|::            ||::   ...|.|:|...:.....|    :..|..:..::||
Zfish   737 SYRRLVKDIED------------GTVV---SGDSFYIRLNLNISSQSD----NCSLNVRCDEVLH 782

  Fly   892 VTNASDD---EWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQG 939
            |.:....   ||..||.....::|...|.:||..|.::.:..:.:.:..:|
Zfish   783 VLDTMHQDKCEWLCARVDPFTDKDLDKGTIPSYSRAQQLLLVKIQKLMCRG 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	11/56 (20%)
		PDZ	454..540	CDD:214570	15/85 (18%)
		PDZ_signaling	566..655	CDD:238492	11/88 (13%)
		PDZ_signaling	742..820	CDD:238492	23/85 (27%)
		SH3_DLG-like	862..922	CDD:212795	15/62 (24%)
card11	XP_009297971.1	DD	16..101	CDD:301326	1/1 (100%)
		BAR	<159..>251	CDD:299863	22/111 (20%)
		iSH2_PI3K_IA_R	187..333	CDD:304922	30/153 (20%)
		SPATA1_C	294..434	CDD:292371	26/175 (15%)
		PDZ_signaling	660..732	CDD:238492	24/73 (33%)
		SH3	754..819	CDD:302595	17/68 (25%)
		NK	<981..1114	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910