DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and PALS2

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001289966.1	Gene:	PALS2 / 51678	HGNCID:	18167	Length:	540	Species:	Homo sapiens

Alignment Length:	428	Identity:	101/428 - (23%)
Similarity:	155/428 - (36%)	Gaps:	135/428 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 IPGDNG------IYVTKLMDG----GAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELA-VATL 644
            :|...|      |::..:|:.    ..|:...||. ..||.||    |:.|||.|...|. :..|
Human    11 LPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLE-DSKLEAV----SDNNLELVNEILEDITPL 70

  Fly   645 KSITDKVTLIIG--KTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNS 707
            .::.:.|..::|  |..|.               |.|.::...:|     |:.:....::|.:|:
Human    71 INVDENVAELVGILKEPHF---------------QSLLEAHDIVA-----SKCYDSPPSSPEMNN 115

  Fly   708 QSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQK---GPQGLGFNIVGGEDGQGIYV 769
            .|.        .|.|..|.     |:         |.:.|.|   .|.|:.|.:    :...:.:
Human   116 SSI--------NNQLLPVD-----AI---------RILGIHKRAGEPLGVTFRV----ENNDLVI 154

  Fly   770 SFILAGGPADLGSELKRGDQLLSVNNVNLTHATHE------EAAQALKTSGGVVTL--LAQYRPE 826
            :.||.||..|....|..||.:..||.       ||      |..:.||...|.|||  |..||.
Human   155 ARILHGGMIDRQGLLHVGDIIKEVNG-------HEVGNNPKELQELLKNISGSVTLKILPSYRD- 211

  Fly   827 EYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSR--GLPFKHGDI 889
                                        |...:.::|:..|||:|..|:.:|.:  ||.|..|:|
Human   212 ----------------------------TITPQQVFVKCHFDYNPYNDNLIPCKEAGLKFSKGEI 248

  Fly   890 LHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERK----MRARDRSVKFQGHAAANNNLDKQ 950
            |.:.|..|..||||..|   .|....|::||:...|::    .|..|.|..|.|
Human   249 LQIVNREDPNWWQASHV---KEGGSAGLIPSQFLEEKRKAFVRRDWDNSGPFCG----------- 299

  Fly   951 STLDRKKKN---FTFSRKFPFMKSRDEKNEDGSDQEPF 985
             |:..|||.   :..:|...|.:...:..|:.:...||
Human   300 -TISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPF 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492	19/74 (26%)
		PDZ_signaling	742..820	CDD:238492	25/88 (28%)
		SH3_DLG-like	862..922	CDD:212795	24/61 (39%)
PALS2	NP_001289966.1	L27	2..55	CDD:197794	12/48 (25%)
		L27	57..108	CDD:397114	13/70 (19%)
		PDZ_signaling	133..206	CDD:238492	24/83 (29%)
		SH3_MPP6	219..279	CDD:212971	24/62 (39%)
		Guanylate_kin	337..527	CDD:395500	101/428 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810