DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Mpp2

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001343253.1	Gene:	Mpp2 / 50997	MGIID:	1858257	Length:	569	Species:	Mus musculus

Alignment Length:	323	Identity:	78/323 - (24%)
Similarity:	120/323 - (37%)	Gaps:	103/323 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 KLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQ 683
            ||.|||.|    |||.|...|                                     :.|::..
Mouse    76 KLEAVRDN----NLELVQEIL-------------------------------------RDLAELA 99

  Fly   684 SQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREP------ 742
            .|.:|:...:::.|:.|...::.:..:.....|.:       ||.:|....|  .:.:|
Mouse   100 EQSSTAAELARILQEPHFQSLLETHDSVASKTYET-------PPPSPGLDPT--FSNQPVPPDAV 155

  Fly   743 RTITIQK--GPQ-GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHE 804
            |.:.|:|  |.. |:.|.:.|||    :.::.||.||.......|..||.:..||...:  .:..
Mouse   156 RMVGIRKTAGEHLGVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV--GSDP 214

  Fly   805 EAAQAL--KTSGGVV-TLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRAL 866
            .|.|.|  ..||.|: .:|..|                |:..|             .|.::|:..
Mouse   215 RALQELLRSASGSVILKILPSY----------------QEPHL-------------PRQVFVKCH 250

  Fly   867 FDYDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERK 927
            |||||.||...|.:  ||.|..||:|.:.|..|..||||..|.|.:    .|::||:...|::
Mouse   251 FDYDPARDSLSPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS----AGLIPSQLLEEKR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492	11/35 (31%)
		PDZ_signaling	742..820	CDD:238492	25/89 (28%)
		SH3_DLG-like	862..922	CDD:212795	26/61 (43%)
Mpp2	NP_001343253.1	L27	30..83	CDD:197794	5/6 (83%)
		L27	85..136	CDD:308467	10/94 (11%)
		PDZ_signaling	155..233	CDD:238492	24/83 (29%)
		SH3_MPP2	246..304	CDD:212970	26/61 (43%)
		GuKc	376..557	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810