DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and dlg1b

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_009295207.1	Gene:	dlg1b / 497648	ZFINID:	ZDB-GENE-050222-3	Length:	990	Species:	Danio rerio

Alignment Length:	863	Identity:	358/863 - (41%)
Similarity:	480/863 - (55%)	Gaps:	203/863 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 AHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLD---------- 359
            |.|||.|||:|.::||..:||.||.:|:|||.||:|.|||||:|||||||:||||
Zfish     8 AQRALLLLEEYRSKLSSTEDRQLRHSIQRVIDIFQSNLFQALIDIQEFYEVTLLDTERCGELVKV 72

  Fly   360 ----------DSKSIQQKTA-------------------ETLQIATKWEKDG------------- 382
                      |..|||..|.                   |.|.:..|.:...
Zfish    73 PDALPPVNLWDFSSIQSTTVTSDTLPSLSTSIEDSPLLNEILHVLAKAKSSSSDLDQKYRHQDED 137

  Fly   383 -------------------QAVKIADNQRMRIES-------------DTENAK------EPTVEQ 409
                               :.|::|:....:||:             ..|:.:      .|.|::
Zfish   138 TGSPQEPSSPQFTDDTPGPELVQVAEKSLSQIENVHGFVAHSHISPMKVESLECIFDGPSPVVKE 202

  Fly   410 QQKQQQAQQRSSRSPQ-----QQ--------------------------NPQQQQ--------GS 435
            :.....:...|:..||     ||                          :|...|        .:
Zfish   203 ESPPSPSTPLSNPYPQSPVSVQQTDAVPPSTLIIPVIPISTVPTEPAVISPSTSQANPPPVVVNT 267

  Fly   436 KSRSGSQTVNGDDS-WLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGR 499
            :|...:..|||.:: :.||:|.||||||||||||||||||||||.|.||:|||:|.|||||.|||
Zfish   268 ESLDSAPYVNGTEADFEYEEITLERGNSGLGFSIAGGTDNPHIGEDPSIFITKVIPGGAAAQDGR 332

  Fly   500 LSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGP 564
            |.:||:|:.||:|.|.||.|:.||:|||:||::|:|:|:|::                   ::..
Zfish   333 LRVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRK-------------------SASE 378

  Fly   565 KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSE 629
            ||:||.|:||.||||||||||:|||||||||.|||||:::||||..||||.|||||:||.::
Zfish   379 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKLLAVNSS--- 440

  Fly   630 KNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQ 694
             .||.||||.||..||:..|.|.|.:.|...:..:.|       .:...::.|.||
Zfish   441 -CLEEVTHEHAVTALKNTPDVVYLKVAKPNSVFMNDS-------FAPPDITNSYSQ--------- 488

  Fly   695 VHQQQH-ATPMVNSQSTEP--GSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGF 756
             |.:.| :.|...||...|  ..|::.|       |.|  .|..:|:|||||.:.:.:|..||||
Zfish   489 -HMENHISPPSYLSQPLPPVHSGRFSPT-------PKT--TVGDDDVTREPRKVVLHRGTTGLGF 543

  Fly   757 NIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLA 821
            ||||||||:||::|||||||||||..||::||:|:|||.::|..||||:||.|||.:|..||::|
Zfish   544 NIVGGEDGEGIFISFILAGGPADLCGELRKGDRLVSVNGIDLRGATHEQAAAALKNAGQTVTIVA 608

  Fly   822 QYRPEEYNRFEARIQELKQQAALG--AGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPF 884
            |||||||:||||:|.:|::|....  :.|||: |||:||||||||||||||..:|.||||:||.|
Zfish   609 QYRPEEYSRFEAKIHDLREQMMNSSISSGSGS-LRTSQKRSLYVRALFDYDKTKDSGLPSQGLNF 672

  Fly   885 KHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDK 949
            |.||||||.|||||||||||:|....|.|::|::|||||.|:|.|||.::|||.     :.:.:|
Zfish   673 KFGDILHVVNASDDEWWQARQVTAQGEVEEMGVIPSKRRVEKKERARLKTVKFN-----SKSREK 732

  Fly   950 QSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGGEIIYRVELPDMEQIT 1014
            .|..|::|||. |||||.|.|::|...::.||.|..:      .:||...|..||    ..|:..
Zfish   733 GSLNDKRKKNL-FSRKFTFYKNKDVSEQETSDVEQHV------TSNASDSESSYR----GQEEYV 786

  Fly  1015 LIY--LENNDADYRKSSI 1030
            |.|  :...:.:|.:..|
Zfish   787 LSYEPVSQQEVNYSRPVI 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	35/53 (66%)
		PDZ	454..540	CDD:214570	59/85 (69%)
		PDZ_signaling	566..655	CDD:238492	58/88 (66%)
		PDZ_signaling	742..820	CDD:238492	49/77 (64%)
		SH3_DLG-like	862..922	CDD:212795	41/59 (69%)
dlg1b	XP_009295207.1	L27_1	4..62	CDD:286187	35/53 (66%)
		MAGUK_N_PEST	130..286	CDD:287565	18/155 (12%)
		PDZ_signaling	287..371	CDD:238492	58/83 (70%)
		PDZ_signaling	380..466	CDD:238492	58/89 (65%)
		PDZ_assoc	467..530	CDD:287558	20/88 (23%)
		PDZ_signaling	529..607	CDD:238492	49/77 (64%)
		SH3_DLG1	647..713	CDD:212964	47/65 (72%)
		Guanylate_kin	799..977	CDD:279019	2/6 (33%)
		GuKc	810..977	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579584
Domainoid	1	1.000	304	1.000	Domainoid score	I1349
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	848	1.000	Inparanoid score	I420
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm25031
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910