DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and sdt

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster

Alignment Length:	1073	Identity:	200/1073 - (18%)
Similarity:	342/1073 - (31%)	Gaps:	355/1073 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SSDPNEGLLSSDDKTFHDDDE---------PAEDSSPADDEEEPEEEECLLPQKKAQIRCDQDQ- 66
            ||:.|...|:|.:.:.|....         .|..||.|.......::..|.|......:..|.|
  Fly  1029 SSNSNSNSLNSSNSSMHTSSSSSGHSSNIASATSSSSATSSSTVPDDLSLAPPGYEVSQQQQQQH 1093

  Fly    67 ---PPLVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMDGDSQLEVMEHQMETVTEPDPEPPKCP 128
               .|:.:|:.|.|:..|:        ||.|.        ||.:|:::      |.|...||
  Fly  1094 LVATPVTMLLPPMAKHREL--------PVDVP--------DSFIEMVK------TTPRYPPP--- 1133

  Fly   129 TSLRDSVRESVECFYSAQDLLEYGHMLSSTSMVRTPDVESGYFEKSESDASRDEWEGPSSSSSGA 193
                                   .|:.|..|::......:.:...|....:.......:::::.|
  Fly  1134 -----------------------AHLSSRGSLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASA 1175

  Fly   194 ARCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQ 258
            :.....:.::..:||..:...|..:..||:                          ..|||.|..
  Fly  1176 SAACATTAVAAAAVSGVADGDARRVADELN--------------------------GNAKPVPPP 1214

  Fly   259 RSHV-------------------QDAAGESGSEQGSERGFWSTIFGQAGLAISQDEEERIADI-Q 303
            |.|:                   :.|.|.:.|             |.:|......:.::||.| :
  Fly  1215 RDHLRVEKDGRLVNCSPAPQLPDRRAPGNASS-------------GSSGATTHPLQHQQIAQIVE 1266

  Fly   304 KAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKT 368
            .....|:.::.|..:|...::...|||.:                 .||...:|
  Fly  1267 PTLEQLDSIKKYQEQLRRRREEEERIAQQ-----------------NEFLRNSL----------- 1303

  Fly   369 AETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQ-----RSSRSPQQQN 428
                               ..:::::...||....:...:|||:...|.|     ..:..|.:..
  Fly  1304 -------------------RGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQ 1349

  Fly   429 PQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGA 493
            ||.:|                           ..|.|..||..|...:          :|...|.
  Fly  1350 PQAEQ---------------------------IDGYGELIAALTRLQN----------QLSKSGL 1377

  Fly   494 AAADGRLS-INDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDAR 557
            :...||:| .:.::.|.:      |.|..|      |...|   ::|:|...:.|...|:.|..:
  Fly  1378 STLAGRVSAAHSVLASAS------VAHVLA------ARTAV---LQRRRSRVSGPLHHSSLGLQK 1427

  Fly   558 DSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIA 622
            |       ::|: |.:........: |.:...|                  :::|.|...|: ||
  Fly  1428 D-------IVEL-LTQSNTAAAIEL-GNLLTSH------------------EMEGLLLAHDR-IA 1464

  Fly   623 VRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLA 687
            ..|:|:.......|..:..||..:::..|.   |..::|                      ..:.
  Fly  1465 NHTDGTPSPTPTPTPAIGAATGSTLSSPVA---GPKRNL----------------------GMVV 1504

  Fly   688 TSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAV---STEDITREPRTITIQK 749
            ..........|:.|.|:...:|..|........:..::|...|.:.   :..|.....|.|.|:|
  Fly  1505 PPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEK 1569

  Fly   750 GPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSG 814
            ..:.||..:  ..:|:.:.:..|:.||.|:....|..||::|.||...|...|..|....|....
  Fly  1570 STEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQ 1632

  Fly   815 GVVTLL---AQYRPEEYNRFEARIQEL-----KQQAALGAGGSGTLLRTTQKRSLYVRALFDYDP 871
            |.:|.|   |...|.        :..:     .|.|.||.....|.:       |:|||.|||||
  Fly  1633 GTLTFLIVPAGSPPS--------VGVMGGTTGSQLAGLGGAHRDTAV-------LHVRAHFDYDP 1682

  Fly   872 NRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRS 934
            ..|..:|.|  |:.|:.||:|||.:..|..||||.|. |:.:....|::||:
  Fly  1683 EDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYRE-GEEDQTLAGLIPSQ------------- 1733

  Fly   935 VKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQE-PFMLC-----YTQDD 993
             .|| |             .|:......:.:....:||   .:|||..: ..:||     ..:..
  Fly  1734 -SFQ-H-------------QRETMKLAIAEEAGLARSR---GKDGSGSKGATLLCARKGRKKKKK 1780

  Fly   994 ANAEGGEIIYRVELPD---------MEQITLIY 1017
            |::|.|..:|....||         .|::.|.|
  Fly  1781 ASSEAGYPLYATTAPDETDPEEILTYEEVALYY 1813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	9/55 (16%)
		PDZ	454..540	CDD:214570	16/86 (19%)
		PDZ_signaling	566..655	CDD:238492	15/88 (17%)
		PDZ_signaling	742..820	CDD:238492	23/77 (30%)
		SH3_DLG-like	862..922	CDD:212795	28/61 (46%)
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	11/70 (16%)
		PDZ_signaling	1562..1640	CDD:238492	24/79 (30%)
		SH3_MPP5	1673..1734	CDD:212969	28/75 (37%)
		Guanylate_kin	1820..1994	CDD:279019
		GuKc	1831..2002	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810