DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and MPP3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001317162.1	Gene:	MPP3 / 4356	HGNCID:	7221	Length:	610	Species:	Homo sapiens

Alignment Length:	288	Identity:	78/288 - (27%)
Similarity:	125/288 - (43%)	Gaps:	66/288 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   681 QSQSQLATSQSQSQVHQQQHATPMVNS---------QSTEPGSRYA---------STNVLAAV-- 725
            :|.|.|.....:.:.:::|..||:::|         :..:..|.::         ||..|.||
Human    66 KSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLM 130

  Fly   726 --------------PPGTPRAVSTEDITREP-RTITIQKGPQGLGFNIVGGEDGQGIYVSFILAG 775
                          || .|..:. ||...|. :.:.:.|..:.||..|...|....:.|:.|:.|
Human   131 VHDTVAQKNFDPVLPP-LPDNID-EDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRG 193

  Fly   776 GPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQ 840
            |.||....:..||:|..||.:.:.|...:|.:|.|..|.|.:||......:|    |.|::|.|
Human   194 GAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQE----EDRLKESK- 253

  Fly   841 QAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQA 903
                                :::||||.|:|..|..:|.:  ||||:...:|.|.:..|..||||
Human   254 --------------------VFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQA 298

  Fly   904 RRVLGDNEDEQIGIVPSKRRWERKMRAR 931
            :|| ||. :.:.|::|||...||::..|
Human   299 KRV-GDT-NLRAGLIPSKGFQERRLSYR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	23/78 (29%)
		SH3_DLG-like	862..922	CDD:212795	26/61 (43%)
MPP3	NP_001317162.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810