Protein Alignment dlg1 and MPP1

DIOPT Version :9

• Sequence 1: NP_001162718.1
• Gene: dlg1 / 32083
• FlyBaseID: FBgn0001624
• Length: 1030
• Species: Drosophila melanogaster
• Sequence 2: NP_002427.1
• Gene: MPP1 / 4354
• HGNCID: 7219
• Length: 466
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 78/306 - (25%)
• Similarity: 129/306 - (42%)
• Gaps: 64/306 - (20%)

  Fly   661 LTTSASGGGGGGLSSGQQLSQSQSQLATS---QSQSQVHQQQHATPMVNSQSTEPGSRYASTNVL 722
            :|..||.|..||     .:..:.|.|...   |.:|:.....|....|.......||
Human     1 MTLKASEGESGG-----SMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGS-------- 52

  Fly   723 AAVPPGTPRAVSTEDITREPRTITIQK---GPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSEL 784
              ..||:|..|..::: |:.|.|..:|   .|.|:...:   .:.|...|:.||.||.......|
Human    53 --PAPGSPAQVKGQEV-RKVRLIQFEKVTEEPMGITLKL---NEKQSCTVARILHGGMIHRQGSL 111

  Fly   785 KRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGS 849
            ..||::|.:|..|:|:.:.::..:|:|.:.|:::|  :..|.:.:|..|
Human   112 HVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQSRLPA---------------- 158

  Fly   850 GTLLRTTQKRSLYVRALFDYDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNED 912
                     ..:::||.|||||.:|:.:|.:  ||.|..|||:.:.|..|..|||. ||.|.::
Human   159 ---------LQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQG-RVEGSSK- 212

  Fly   913 EQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKK 958
            |..|::||....|.::.:..:|        |.:.....|...:|||
Human   213 ESAGLIPSPELQEWRVASMAQS--------APSEAPSCSPFGKKKK 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	21/80 (26%)
		SH3_DLG-like	862..922	CDD:212795	27/61 (44%)
MPP1	NP_002427.1	PDZ	71..149	CDD:366185	21/82 (26%)
		SH3_MPP1	162..223	CDD:213013	27/62 (44%)
		Interaction with PALS1. /evidence=ECO:0000269|PubMed:17584769	268..466
		Guanylate_kin	281..453	CDD:366206

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810