DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and mpp2b

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_005156123.1	Gene:	mpp2b / 431770	ZFINID:	ZDB-GENE-040704-70	Length:	561	Species:	Danio rerio

Alignment Length:	362	Identity:	89/362 - (24%)
Similarity:	131/362 - (36%)	Gaps:	102/362 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 KLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQ 683
            ||.|||.|..|. ::::..:|...:..|......:.|.|..|.                     |
Zfish    67 KLEAVRDNNVEL-VQDILRDLNTLSPDSPAAHELICILKEPHF---------------------Q 109

  Fly   684 SQLATSQSQSQVHQQQHATP-------MVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITRE 741
            |.|.|..|   |..:.:.||       |..:.:.:|            |||...|.|....::.|
Zfish   110 SLLETHDS---VASKSYETPPPSPCAFMDPAFNNQP------------VPPDAVRMVGIRKVSGE 159

  Fly   742 PRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEA 806
            ...:|         |.:.|||    :.::.||.||..|....|..||.:..||...:  .:..:.
Zfish   160 HLGVT---------FRVEGGE----LVIARILHGGMIDQQGLLHVGDIIKEVNGKEV--GSDPKV 209

  Fly   807 AQ-ALKTSGG--VVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFD 868
            .| .||.|.|  |:.:|..|:...                             ..|..:|:..||
Zfish   210 LQNMLKESSGSVVLKILPSYQEPH-----------------------------TPRQAFVKCHFD 245

  Fly   869 YDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRA- 930
            |||:.|:.:|.:  ||.|..||||.:.|..|..||||..:.|.:    .|::|| :..|.|.:|
Zfish   246 YDPSHDNLIPCKEAGLKFSSGDILQIFNQEDPNWWQACHLEGGS----AGLIPS-QLLEEKRKAF 305

  Fly   931 --RDRSVKFQGHAAAN-NNLDKQSTLDRKKKNFTFSR 964
              ||..:...|...|. ....|:..:....||..|.|
Zfish   306 VKRDLELASTGPLCAGIGGKKKKKMMYLTTKNAEFDR 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492	9/35 (26%)
		PDZ_signaling	742..820	CDD:238492	21/80 (26%)
		SH3_DLG-like	862..922	CDD:212795	25/61 (41%)
mpp2b	XP_005156123.1	L27	76..127	CDD:280918	13/75 (17%)
		PDZ_signaling	148..226	CDD:238492	24/92 (26%)
		SH3_MPP2	239..297	CDD:212970	25/62 (40%)
		Guanylate_kin	358..546	CDD:279019
		GuKc	368..546	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810