DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and pyd

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	172/783 - (21%)
Similarity:	284/783 - (36%)	Gaps:	272/783 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 EQQQKQQQAQQRSSRSPQQQNPQQQQG-----------------------SKSRSGSQTV----- 444
            ||||:|||.||:.    ||...|||.|                       ::|||.|.:|
  Fly   115 EQQQQQQQQQQQH----QQVQEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRSRSNSVGNRSI 175

  Fly   445 ---------------------------NGDD---------------------------------- 448
                                       |.||
  Fly   176 TSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKK 240

  Fly   449 ----SWLYEDIQLER-GNSGLGFSIAGGTDNPHIGT-DTSIYITKLISGGAAAADGRLSINDIIV 507
                :|.|..:.:.| ...|.|.:::||.||||... |.||.::.::.||  .|:.||.:||.|:
  Fly   241 GDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGG--PAEDRLQVNDRII 303

  Fly   508 SVNDVSVVDVPHASAVDALKKAGNVVKLHVKRK------------------------------RG 542
            |||.||:.:|.:|:||..|:.:||.|:|.|||:                              .|
  Fly   304 SVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGG 368

  Fly   543 TATTPAAGSAAGDARDSA----ASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLM 603
            .|.||....:..::.:|:    ||..:.|::.|.||||...:.:..|.         .::|.::.
  Fly   369 VAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGC---------RLFVKEIS 424

  Fly   604 DGGAAQVDGR---LSIGDKLIAVRTNG---------SEKNLENVTHELAVATLKSITDKVTLIIG 656
            .....|::..   |..||.:..:....         ::|.::.....|.:..|:.||::..:
  Fly   425 SKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAV--- 486

  Fly   657 KTQHLTTSASGGGGGGLSSGQQ-----LSQSQSQL-------ATSQSQSQVH------------- 696
            ...:|..|||....|.:.:..|     .|.|.:.|       ..|.|...::
  Fly   487 SQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNI 551

  Fly   697 -------QQQHATPMVNSQS---------------TEPGSRYASTNVLAAVPP--GTPRAVSTED 737
                   ::.:.||...|:.               |....|.|:.:.....||  |:....:.||
  Fly   552 NGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQED 616

  Fly   738 I------------TREPRTITIQKGPQG-LGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQ 789
            .            :.|||.|:.||  :| :|..:.||.:. ||:|:.:..|.||.| ..|..||:
  Fly   617 FYSSRRQLYEERQSAEPRFISFQK--EGSVGIRLTGGNEA-GIFVTAVQPGSPASL-QGLMPGDK 677

  Fly   790 LLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLR 854
            :|.||::::...|.|||...|.:....:.|:.||..|||:..
  Fly   678 ILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEV----------------------- 719

  Fly   855 TTQKR--SLYVRALFDYDPNRDDGLPSRG-LPFKHGDILHVTNASDD---EWWQARRVLGDNEDE 913
            .|.:|  |.:::..|..|.      ||:| :.||.||:..|.:...:   ..||..::...:::.
  Fly   720 VTNQRGDSFHIKTHFHCDN------PSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEM 778

  Fly   914 QIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNED 978
            |.|::|:|.|.|....|:..:.|            |:...:..:.||...|:....:|:....|:
  Fly   779 QRGVIPNKSRAEELATAQFNATK------------KEMNANESRGNFFRRRRSTHRRSKSLSREN 831

  Fly   979 GSD 981
            ..|
  Fly   832 WDD 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570	36/87 (41%)
		PDZ_signaling	566..655	CDD:238492	17/100 (17%)
		PDZ_signaling	742..820	CDD:238492	27/78 (35%)
		SH3_DLG-like	862..922	CDD:212795	15/63 (24%)
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	34/86 (40%)
		PDZ_signaling	396..477	CDD:238492	14/89 (16%)
		PDZ_signaling	633..710	CDD:238492	28/80 (35%)
		SH3_ZO	729..790	CDD:212793	17/66 (26%)
		GuKc	831..1007	CDD:214504	1/4 (25%)
		ZU5	2263..2351	CDD:279170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910