DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and magu-2

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001355433.1	Gene:	magu-2 / 3565703	WormBaseID:	WBGene00006467	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	669	Identity:	133/669 - (19%)
Similarity:	227/669 - (33%)	Gaps:	212/669 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 GAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKA--GNVVKLHVKRKRGTATTPAAGSAA- 553
            |.||....|||.|.||.|||:.:....:......:::.  ..:::|.|:|:  ....||...|:
Worm    59 GTAAERAGLSIGDEIVGVNDMKIEGKSYEEVTTYIQECIRRKIIQLKVRRR--ALEIPAENEASV 121

  Fly   554 ----------GDA------RD------------------------SAASGPKVIEIDLVKGGKGL 578
                      .||      :|                        :|.|||..:      ..:|.
Worm   122 FNCTNSNRMITDAYLVSVDKDHIKEVTKRLKKEYPEIHTYDMEYIAATSGPPSV------APRGS 180

  Fly   579 ----GFSIAGGIGNQHIPGD------------------NGIYVTKLMDGGAAQVD---------- 611
                ||.|..  |:...|.:                  :.:..:|.:...|..||
Worm   181 VHTNGFGIER--GSLRRPPEQFEMQEKKRKEQENTFLRSSLRKSKKLQALARNVDPLTNEPMKVT 243

  Fly   612 ---------------------GRLSIGDKLIAV------RTNGSEKNLENVTHELAVATLKSITD 649
                                 .|:::|::::..      ..|...:.|:.|     :.:::.|..
Worm   244 SFANPLAEVEETPSRKTENGATRITVGEEVLESSEVLIDEENKDSRQLDEV-----IISVERIAS 303

  Fly   650 KVTLIIGKTQHLT-----------------TSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQ 697
            |::.:.|:...:.                 |....|..|..|||  :.......::|.:.|.:
Worm   304 KLSSMQGRESDVAMLRDFFAAPPIQAAIEQTVKQNGKCGTTSSG--IGTDSGGDSSSCTSSPI-- 364

  Fly   698 QQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGFNIVGGE 762
                 |.|.........|..||:..::|.|.....|...::.::..:.        ||..:  ..
Worm   365 -----PPVIMNGNGKSERCPSTSSSSSVSPRNAPNVKVVEVVKDEDSY--------LGATV--RN 414

  Fly   763 DGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEE 827
            :...|.|..::.||..:..:..:.||:||.:|..:|......|....|:...|.:|.:...:.|
Worm   415 ENNKIIVGRVVKGGIVEKMNLFQEGDELLELNGSSLKGKQVNEICDILRNLSGPITFVVAPKEE- 478

  Fly   828 YNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSR--GLPFKHGDIL 890
                    |:.:|..  ....:....:.:|:...::||||||||..|..:|.:  .:.|:.||||
Worm   479 --------QDTEQPT--DTATNTVTAKKSQQHVQHLRALFDYDPEDDVYVPCKELAMKFQRGDIL 533

  Fly   891 HVTNASDDEWWQARRVLGDNEDEQ---IGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQST 952
            ||.|..||.||||.|   |.||.|   .|::||.       ..|.:.|.:...........::..
Worm   534 HVLNTKDDNWWQAYR---DGEDIQHSLAGLIPSS-------SFRQQVVLYADEVEREQEQKRKEC 588

  Fly   953 LDRKKKNFTFSRKFPFMKSRDEKN--------------------EDGSDQEPFMLCYTQDDANAE 997
            ..:|||      |....|..||:|                    ...:.:.|.:||      .||
Worm   589 KGKKKK------KLEVKKGADEENLPAIGVYSDFLTYEEVVLELPKATHRRPIVLC------GAE 641

  Fly   998 G-GEIIYRVELPDMEQITL 1015
            | |.:..|..|.:.::|||
Worm   642 GVGCLKLRDRLLESDRITL 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570	14/49 (29%)
		PDZ_signaling	566..655	CDD:238492	17/147 (12%)
		PDZ_signaling	742..820	CDD:238492	16/77 (21%)
		SH3_DLG-like	862..922	CDD:212795	32/64 (50%)
magu-2	NP_001355433.1	PDZ	<59..107	CDD:238080	13/47 (28%)
		PDZ_signaling	408..474	CDD:238492	16/67 (24%)
		SH3_MPP5	503..565	CDD:212969	32/71 (45%)
		GuKc	642..817	CDD:214504	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820