DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and vari

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	110/403 - (27%)
Similarity:	171/403 - (42%)	Gaps:	82/403 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   682 SQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRY--------ASTNVL-AAVPPGTPRAVSTED 737
            |.|:...|:..:::..|.|...::.:.. |.|:.|        .||:.| .|....|...:.|||
  Fly    99 SPSRRLESRELAKLLAQPHFRALLRAHD-EIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTED 162

  Fly   738 I--TREP----RTITIQKGP-QGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNN 795
            :  |:.|    :.:.:::.| :.||..:...|..| :.|:.|||||..|..|.|..||.:|.||.
  Fly   163 VLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQ-LVVARILAGGVIDKQSMLHVGDVILEVNG 226

  Fly   796 VNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGG----SG-TLLRT 855
            ..:  .|.:|....:..:...:||......:|         |:|......:||    :| ..|.|
  Fly   227 TPV--RTPDELQVEVSRAKENLTLKIGPNVDE---------EIKSGRYTVSGGQVKQNGIASLET 280

  Fly   856 TQKRSLYVRALFDYDPNRDDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIV 918
            .:|.:.|:||||.|:|:.|..||.|  |||||.||||.:.|..|..||||:.:..  |.::||::
  Fly   281 GKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITA--ESDKIGLI 343

  Fly   919 PSKRRWERK------------------MRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRK 965
            ||:...||:                  .|...|..|....:.||...||...|..::    .:|.
  Fly   344 PSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEE----VTRM 404

  Fly   966 FPFMKS------------RDEKNE-DGSDQEPF--MLCYTQDDANA--EGGEIIYRVELPDMEQI 1013
            .||.:.            |..||. ..||.:.|  ::.:|.....|  |.|...:.::..:||:.
  Fly   405 PPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEA 469

  Fly  1014 T-----LIYLENN 1021
            .     |.|.|:|
  Fly   470 VRNNEFLEYGEHN 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	23/82 (28%)
		SH3_DLG-like	862..922	CDD:212795	31/61 (51%)
vari	NP_724288.3	L27	<105..128	CDD:280918	3/23 (13%)
		PDZ_signaling	173..250	CDD:238492	23/79 (29%)
		SH3_MPP	287..347	CDD:212796	31/61 (51%)
		Guanylate_kin	408..622	CDD:279019	16/75 (21%)
		GuKc	418..622	CDD:214504	16/65 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810