DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Dlg5

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	684	Identity:	159/684 - (23%)
Similarity:	244/684 - (35%)	Gaps:	177/684 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 DNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYE 453
            ||||:||.|:      |:|..:..........|...............|.|.|.:.....|.:..
  Fly  1164 DNQRLRIPSN------PSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSS 1222

  Fly   454 DIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVP 518
            .|     ::..|.:||||.     ||.:||.    :.||.....||.|      .:..|.|..:.
  Fly  1223 SI-----HNSYGANIAGGN-----GTGSSIG----VGGGGGGGSGRGS------PMPQVHVEVLS 1267

  Fly   519 HASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIA 583
            |...... |:..||              ||.....||.|          .:.:.|..|.||.:|.
  Fly  1268 HGGGGSG-KRNSNV--------------PADFLCPGDLR----------RVTIDKRDKSLGITIQ 1307

  Fly   584 ----GGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATL 644
                ||          ||:|:.:.|...|...| |.:||:|:.|    ...|:...|.|:|...|
  Fly  1308 CNNNGG----------GIFVSTVADKSTAMRAG-LQVGDQLLEV----CGINMRAATQEIAANVL 1357

  Fly   645 KSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPM-VNSQ 708
            :...|..|:::........|....|...|.....::.|.|....:..:..........|| ..:.
  Fly  1358 RQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAP 1422

  Fly   709 STEPGSR--------------------------------YASTNVLAA--------------VPP 727
            ||.||||                                .|:|....|              :||
  Fly  1423 STRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPP 1487

  Fly   728 GTPRAVSTEDITREPRTITIQKG-PQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLL 791
             .|.:|..|.:    |.:|:... .:.||..:.|| :..||||..:..|.|:| .:.:::|||:|
  Fly  1488 -PPASVPAETL----RYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSD-HAGIRKGDQIL 1545

  Fly   792 SVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTT 856
            ..|.|:|:..|.|:||..:......||:|.|          .::..|||            ::..
  Fly  1546 EYNGVDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ------------IKDE 1588

  Fly   857 QKRSLYVRALFDY--DPNRDDGLPSRGLPFKHGDILHVTNA---SDDEWWQARRVLGDNEDEQIG 916
            ...|.|:|..||.  :.|.||      |.|...::|:|.|.   .....|:|.::......::.|
  Fly  1589 PGDSFYIRVGFDRTGELNEDD------LRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECG 1647

  Fly   917 IVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSD 981
            |:||:.:.|.::|:.:......|.|...:...::|...|||...:.||             |.::
  Fly  1648 IIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFRRKKNQRSSSR-------------DSTE 1699

  Fly   982 QEPF---MLCYTQDDA--NAEGGEIIY-RVELPD 1009
            ...|   .|.:..|..  |.:||.:.| ||||.|
  Fly  1700 IASFSNTQLSFFPDLGLLNDDGGALSYQRVELLD 1733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570	21/85 (25%)
		PDZ_signaling	566..655	CDD:238492	25/92 (27%)
		PDZ_signaling	742..820	CDD:238492	26/78 (33%)
		SH3_DLG-like	862..922	CDD:212795	18/64 (28%)
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	26/103 (25%)
		PDZ_signaling	1497..1576	CDD:238492	27/84 (32%)
		SH3_DLG5	1594..1657	CDD:212794	18/68 (26%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810