DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Card10

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_038935185.1	Gene:	Card10 / 315120	RGDID:	1304949	Length:	1109	Species:	Rattus norvegicus

Alignment Length:	936	Identity:	179/936 - (19%)
Similarity:	303/936 - (32%)	Gaps:	356/936 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 RSHVQDAAGESGSEQGSER---GFWSTIFG-------------------QAGLAISQDEEERIAD 301
            |:...:|..|:|:..|||.   ..|..|.|                   |..:...|||||.::.
  Rat    53 RADAAEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNPAKLTPYLRQCRVLDEQDEEEVLST 117

  Fly   302 IQ---KAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFY---ELTLLDD 360
            .:   :|:|...|::                    ::|....|.|:|.|:..|||   ..|||..
  Rat   118 YRFPCRANRTGRLID--------------------ILRCRGKRGFEAFLEALEFYYPEHFTLLTG 162

  Fly   361 SKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQR-----S 420
            .:..|       :.:...:::|     .:.....:.::....:|....|..::||.|.|     .
  Rat   163 QEPAQ-------RCSMILDEEG-----PEGLTQFLMTEVRRLREARKSQLHREQQLQARGRALEE 215

  Fly   421 SRSPQQQNPQQQQGSKSRSGSQTVNGD-DSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIY 484
            .|:..:|..::||.::.|  .|.:..| ::...|.::|:..|..:...:|..::..
  Rat   216 ERAGLEQRLREQQAAQER--CQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEK--------- 269

  Fly   485 ITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKR--------KR 541
                              |..::...|:.:       |||.|       ||.|.|        :|
  Rat   270 ------------------NSAVLRSRDLQL-------AVDQL-------KLKVSRLEEECALLRR 302

  Fly   542 GTATTPAAGSAAGDARDSAASGPKVI------------EIDLVKGGKGLGFSIAGGIGNQHIPGD 594
            |....|.|     :.::....|..::            .:..::.|.....|..|..|::.|
  Rat   303 GRGPPPGA-----EEKEKEPDGVDLLSELRAENQRLTASLQELQEGLQQEMSRPGAAGSERI--- 359

  Fly   595 NGIYVTKLM--DGGAAQVDGRLSIGDKLIAVRTNGS--------EKNLENV-------------- 635
                :..::  |...|| |.|..:..||.||:  |.        :|.|:.:
  Rat   360 ----LLDILEHDWREAQ-DSRQELCQKLHAVQ--GELQWAEELRDKYLQEMEDLRLKHRTLLKDC 417

  Fly   636 ---THELA--VATLKSI----------TDKVTL-----IIGKTQH--------------LTTSAS 666
               .|.:|  :|.|:.|          .|::.|     :|.|.|:              |||..|
  Rat   418 DLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTVTS 482

  Fly   667 ----------------GGGG-----------GGLSSGQQLSQSQSQL----ATSQS-QSQVHQQQ 699
                            ||..           ..|||...||:..|.|    ||.:: .|:.|..:
  Rat   483 LEGTKAMLEAQLQRTQGGSSLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGETGGSEPHTSE 547

  Fly   700 HATPM---VNSQSTEP-----GSRYASTNVLAAVPPGTPRAVST-EDITREPRTITIQKGPQGLG 755
            .||..   :|..|..|     ||...........||  .|:.|: .|||   .::|::....||.
  Rat   548 EATDSEKEINRLSILPFPPSAGSILRRQREEDPEPP--KRSFSSMSDIT---GSVTLKPWSPGLS 607

  Fly   756 FNI-------VGGEDG---QGIYVSFILAGGPADLGSELKRGDQLLSVNNV-------NLTHATH 803
            .:.       :|..:|   :|..:.|        |.|.:.|.|..:|....       :|..|:.
  Rat   608 SSSSSDSVWPLGKPEGLLARGCGLDF--------LNSSILRWDPAVSSPEASSEPLCPSLAAASR 664

  Fly   804 EEA--------AQALKTSG-------------------------GVVTLLAQYRPEEYNRFEARI 835
            .||        :.|::.||                         |.|.......|.     .||.
  Rat   665 LEANGCSLLELSLAIRVSGWSPSGGLDPQDKSPDSLPILGDRWSGAVVRRVLSGPG-----SART 724

  Fly   836 QELKQQAALGAGGSGTLLRT-TQKRSL------------------------------------YV 863
            :: |:..|.|:|..||.|.. .|:|:|                                    |:
  Rat   725 EQ-KEPRAEGSGLEGTGLEAEVQQRTLPWNQSSTLPFLLDSKACQSFHEALDVWAKGPGAEPFYI 788

  Fly   864 RALFDYDPNRDDGLPSRGLPFKHGDILHVTNAS---DDEWWQARRVLGDNEDEQIGIVPSKRRWE 925
            ||.|.. |.|.|   ...|..|..:||.:.:.:   ..||:..|.......|...|.||:.:|.:
  Rat   789 RANFSL-PERAD---PHALCVKAQEILRLVDPAYKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQ 849

  Fly   926 RKMRARDRSVKFQGHAAANNNLDKQS 951
            :.:..:::.:....|.:..:||.|::
  Rat   850 QLLEVQEKYLISSRHRSPRSNLKKRA 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	13/61 (21%)
		PDZ	454..540	CDD:214570	13/93 (14%)
		PDZ_signaling	566..655	CDD:238492	24/144 (17%)
		PDZ_signaling	742..820	CDD:238492	21/127 (17%)
		SH3_DLG-like	862..922	CDD:212795	18/62 (29%)
Card10	XP_038935185.1	CARD_CARD10_CARMA3	76..161	CDD:260069	22/104 (21%)
		Smc	<196..>499	CDD:224117	62/360 (17%)
		SH3	784..849	CDD:418401	19/68 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810