DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and Pals1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001101504.1	Gene:	Pals1 / 314259	RGDID:	1308071	Length:	675	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	78/316 - (24%)
Similarity:	134/316 - (42%)	Gaps:	66/316 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 VHQQ--QHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITRE-------------PRT 744
            |||:  |..|.::|:...:.        :|.|......:.:..|.||.|             .:.
  Rat   200 VHQKEGQELTALLNAPHIQA--------LLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKI 256

  Fly   745 ITIQKGPQ-GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQ 808
            :.|:|... .||..:....|  .:.:|.|:.||.|:....|..||::|.:|.:.:......|...
  Rat   257 VRIEKARDIPLGATVRNEMD--SVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFD 319

  Fly   809 ALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNR 873
            .|....|.:|.:.           ...|::|...|             ::..::|:|.|||||:.
  Rat   320 LLSDMHGTLTFVL-----------IPSQQIKPPPA-------------KETVIHVKAHFDYDPSD 360

  Fly   874 DDGLPSR--GLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQI-GIVPSKRRWERKMRARDRSV 935
            |..:|.|  ||.|:.||||||.:..|..||||.|. ||.:::.: |:||.| .::::..|..:::
  Rat   361 DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYRE-GDEDNQPLAGLVPGK-SFQQQREAMKQTI 423

  Fly   936 KFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQ 991
            :      .:...:|...|...|||....:|..:   ...||:|..::|  :|.|.:
  Rat   424 E------EDKEPEKSGKLWCAKKNKKKRKKVLY---NANKNDDYDNEE--ILTYEE 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570
		PDZ_signaling	566..655	CDD:238492
		PDZ_signaling	742..820	CDD:238492	19/78 (24%)
		SH3_DLG-like	862..922	CDD:212795	30/62 (48%)
Pals1	NP_001101504.1	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	1..345		34/178 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Interaction with PARD6B. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	21..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..79
		L27_N	123..170	CDD:401122
		Interaction with LIN7C. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	181..243		12/50 (24%)
		L27	189..237	CDD:197794	9/44 (20%)
		PDZ_signaling	254..333	CDD:238492	19/91 (21%)
		SH3_MPP5	349..411	CDD:212969	31/63 (49%)
		GuKc	491..661	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810