DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Dlg5

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001358932.1	Gene:	Dlg5 / 305645	RGDID:	1308753	Length:	1925	Species:	Rattus norvegicus

Alignment Length:	1013	Identity:	206/1013 - (20%)
Similarity:	365/1013 - (36%)	Gaps:	282/1013 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DEEEPEEEECLLPQKKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMDGDSQ 106
            |:.:.:::..:|.::..::|.:::      |:|.|.|.::..:|.|.       .:..|:....|
  Rat   236 DQTQLKDDVDMLRRENGKLRRERN------LLQQSWEDMKRLREEDQ-------KEIGDLRAQQQ 287

  Fly   107 LEVMEHQMETVTEPDPEPPKCPTSLRDSVRESVECFYSAQDLLEYGHMLSSTSMVRTPDVESGYF 171
             :|::|...:         :....|.|:..:.:|......|.|                 ...|.
  Rat   288 -QVLKHNGSS---------EILNKLYDTAMDKLEVVKKDYDAL-----------------RKRYS 325

  Fly   172 EK---SESDASRDEWEGPSSSSSGAARCRLLSGISGLSVSSSSRHSAEGLR----MELSRFRTMI 229
            ||   ..||.||.|..|..:.       ||......|   :..|.:|..|:    :.|.||.|:.
  Rat   326 EKVAMHNSDLSRLEQLGEENQ-------RLQKQTEML---TQQRDTAIQLQHQCALSLRRFETIH 380

  Fly   230 ETL------------ERESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERGFWST 282
            ..|            |.|.|:...:||:.|....||...|.:.. :||
  Rat   381 HELSKATAQNKDLQWEMELLQSELTELRSKQVKTAKESEKYKEE-RDA----------------- 427

  Fly   283 IFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALL 347
            ::.:..|.:| :.::.|:::.|....:||.|. ..:.|..:.:|   |.|.|         :||.
  Rat   428 VYSEYKLIMS-ERDQVISELDKLQTEVELAES-KLKSSTSEKKA---ASEEV---------EALR 478

  Fly   348 DIQEFYEL----------TLLDDSKSIQQKTAETLQIA------TKW---EKDGQAVK------I 387
            .|::...:          .|....|::.|:..|.||.|      ..|   |:|....:      :
  Rat   479 QIKDTVTMDAGRANKEVEVLRKQCKALCQELKEALQEADVAKCRRDWAFRERDKIVAERDSIRTL 543

  Fly   388 ADN---QRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSR------SGSQT 443
            .||   :|.|..|:...|.....:.::::....:......:|...|.::.::.|      |....
  Rat   544 CDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMECQLEKEARFRQLMAHSSHDSA 608

  Fly   444 VNGDD-SWLYEDIQLERGN-----SGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSI 502
            ::.|. .|..|.::..|..     ..|||.:|.|.:.|....|..|::||:..|  :.|||||.:
  Rat   609 IDTDSMEWETEVVEFVRETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKG--SIADGRLRV 671

  Fly   503 NDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKR---GTATTPAAGSAAGDARDSAASGP 564
            ||.::.:|||.:::.....|:.||......:.:.|:|::   |...||
  Rat   672 NDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTP----------------- 719

  Fly   565 KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSE 629
              :.|:| .|.|..|.|:           :||:|...::.|..|..:|.|::||:::|:  ||..
  Rat   720 --LHINL-SGQKDSGISL-----------ENGVYAAAVVPGSPAAKEGSLAVGDRIVAI--NGIA 768

  Fly   630 KNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLA--TSQSQ 692
              |:|.:.....:.|:|..|.:||.:.|....::|.|     |.:..:.:..|...|:  ....:
  Rat   769 --LDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWS-----GQNIFENIKDSDRMLSCRAHGPE 826

  Fly   693 SQVHQQQHATPMVNSQSTE-----------------PGSRYASTNVLAAVPPGTPRA-------- 732
            .|.|.:::.....||..|:                 ..|.|.......|..|.:|:|
  Rat   827 VQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELDHSGGSSSYLYKPFSGASSPASPQACPSTSERS 891

  Fly   733 -------VSTE------DITREPRTITIQK--GPQGLGFNIVG---------GEDGQGIYVSFIL 773
                   .|.|      |:..:...::.:.  ||.|    .||         |.:..|.:...:|
  Rat   892 LNSFRSDTSAERGYGLVDVQSQRPLLSFETEVGPCG----TVGAPLDKIDPEGSNSGGTWPKAVL 952

  Fly   774 --AGGPADLGSELKRGDQLLSVNNVN-------------------LTHATHEEAAQALKTSGGVV 817
              ..||..| |..|:..|..|:.:.|                   |||:  .:.::...|..|.:
  Rat   953 GSTSGPEKL-SVYKKPKQRKSIFDPNTFKRPQTPPKVDYLLPGLGLTHS--PQPSKRADTPKGSL 1014

  Fly   818 TLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTL---------------LRTTQKRSLYVRALF 867
            |.....|..:..:|:.|::...:..|...|.|.:.               :..:..|...||...
  Rat  1015 TPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSAPPPSMDPSEPMHASPPRKARVRIAS 1079

  Fly   868 DYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARR 905
            .|. :..||..|. ||.|......:|:...||..|.||
  Rat  1080 SYH-SEGDGDTSY-LPVKKPCDEDLTSQKVDELGQKRR 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	13/65 (20%)
		PDZ	454..540	CDD:214570	26/90 (29%)
		PDZ_signaling	566..655	CDD:238492	25/88 (28%)
		PDZ_signaling	742..820	CDD:238492	22/109 (20%)
		SH3_DLG-like	862..922	CDD:212795	15/44 (34%)
Dlg5	NP_001358932.1	Takusan	129..213	CDD:398477
		Smc	<141..564	CDD:224117	80/409 (20%)
		Cep57_CLD_2	<545..585	CDD:372959	6/39 (15%)
		PDZ_signaling	620..707	CDD:238492	25/88 (28%)
		PDZ_signaling	722..790	CDD:238492	23/83 (28%)
		PDZ	1351..1433	CDD:214570
		dbPDZ_assoc	1431..1506	CDD:406907
		PDZ	1506..1588	CDD:214570
		SH3_DLG5	1604..1666	CDD:212794
		GuKc	1738..1914	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910