DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and Guk1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_006246539.1	Gene:	Guk1 / 303179	RGDID:	1309638	Length:	266	Species:	Rattus norvegicus

Alignment Length:	182	Identity:	39/182 - (21%)
Similarity:	70/182 - (38%)	Gaps:	42/182 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 SWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTS---IYITK-LISGGAAAAD--------GRL- 500
            |.|.:.:..|.| |..|||::..|.||..|.:..   .::|: ::....||.|        |.|
  Rat    86 STLLKKLFQEHG-SVFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLY 149

  Fly   501 ----SINDIIVSVNDVSVVDVPHASAVDALKKAG-NVVKLHVK-----------RKRGTATTPAA 549
                .....:.::|.:.|:|| ....|.::||.. :.:.:.|:           |:|.|.|..:.
  Rat   150 GTSKEAVRAVQAMNRICVLDV-DLQGVRSIKKTDLHPIYISVQPPSMDVLEQRLRQRNTETEESL 213

  Fly   550 GS--AAGDARDSAASGPKVIEIDLVKGG---------KGLGFSIAGGIGNQH 590
            ..  ||..|...::..|.:.::.:|...         :.|...|....|.:|
  Rat   214 AKRLAAAQADMESSKEPGLFDLVIVNDNLDEAYVTLKQALSEEIKKAEGTEH 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570	24/114 (21%)
		PDZ_signaling	566..655	CDD:238492	5/34 (15%)
		PDZ_signaling	742..820	CDD:238492
		SH3_DLG-like	862..922	CDD:212795
Guk1	XP_006246539.1	Guanylate_kin	71..256	CDD:279019	36/171 (21%)
Guk1	XP_006246539.1	guanyl_kin	73..255	CDD:213788	36/170 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810