DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dlg1 and CARD10

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_055365.2	Gene:	CARD10 / 29775	HGNCID:	16422	Length:	1032	Species:	Homo sapiens

Alignment Length:	922	Identity:	167/922 - (18%)
Similarity:	277/922 - (30%)	Gaps:	351/922 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 RSHVQDAAGESGSEQGSER---GFWSTIFG-------------------QAGLAISQDEEERIAD 301
            |:...:|..|:|:..|||.   ..|..|.|                   |..:...|||||.::.
Human     4 RAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLST 68

  Fly   302 IQ---KAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFY---ELTLLDD 360
            .:   :.:|...|::                    ::|....|.::|.|:..|||   ..|||..
Human    69 YRFPCRVNRTGRLMD--------------------ILRCRGKRGYEAFLEALEFYYPEHFTLLTG 113

  Fly   361 SKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQR-----S 420
            .:..|       :.:...:::|     .:.....:.::....:|....|.|::||.|.|     .
Human   114 QEPAQ-------RCSMILDEEG-----PEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEE 166

  Fly   421 SRSPQQQNPQQQQGSKSRSGSQTVNGD-DSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIY 484
            .|:..:|..:.||.::.|  .|.:..| ::...|.::|:..|..:...:|..::..
Human   167 ERAGLEQRLRDQQQAQER--CQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEK--------- 220

  Fly   485 ITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLH-----VKRKRGTA 544
                              |..::...|:.:       |||.||.  .|.:|.     ::|.||
Human   221 ------------------NSAVLRSRDLQL-------AVDQLKL--KVSRLEEECALLRRARG-- 256

  Fly   545 TTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGI-----GNQH------IPGDNGIY 598
              |..|:...:........|.  .:|||...:.....:...:     |.|.      .||...|.
Human   257 --PPPGAEEKEKEKEKEKEPD--NVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERIL 317

  Fly   599 VTKLMDGGAAQVDGRLSIGDKLIAV-------------------------RTNGSEKNLENVTHE 638
            :..|........|.|..:..||.||                         ||  .:|:.:...|.
Human   318 LDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRT--LQKDCDLYKHR 380

  Fly   639 LA--VATLKSI----------TDKVTL-----IIGKTQH--------------LTTSASGGG--- 669
            :|  :|.|:.|          .|::.|     :|.|.|:              |||..|..|
Human   381 MATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKA 445

  Fly   670 ----------GG--------------GLSSGQQLSQSQSQLATSQSQSQV--------HQQQHAT 702
                      ||              .|||...||:..|.|...::..:.        |..:.||
Human   446 LLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEAT 510

  Fly   703 -----------------------------------------------------PMVNSQSTEPG- 713
                                                                 |.::|.|:...
Human   511 DSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSV 575

  Fly   714 -------------------SRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGFNIV 759
                               :|..:..|....|||.|          ||:    .|||.||.|.
Human   576 WPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGP----------EPQ----DKGPDGLSFY-- 624

  Fly   760 GGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYR 824
             |:...|..|..:|: ||.....|                  ..|:..:|....|..:...||.|
Human   625 -GDRWSGAVVRRVLS-GPGSARME------------------PREQRVEAAGLEGACLEAEAQQR 669

  Fly   825 PEEYNRFEA--------RIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRG 881
            ...:|:...        ..|...:.....|.|.|.       ...|:||.... |.|.|   ...
Human   670 TLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGA-------EPFYIRANLTL-PERAD---PHA 723

  Fly   882 LPFKHGDILHVTNAS---DDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAA 943
            |..|..:||.:.:::   ..||:..|.......|...|.||:.:|.::.:..:::.:....|...
Human   724 LCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGP 788

  Fly   944 NNNLDKQSTLDR 955
            .:||.|:: ||:
Human   789 RSNLKKRA-LDQ 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	11/61 (18%)
		PDZ	454..540	CDD:214570	12/90 (13%)
		PDZ_signaling	566..655	CDD:238492	25/141 (18%)
		PDZ_signaling	742..820	CDD:238492	17/77 (22%)
		SH3_DLG-like	862..922	CDD:212795	17/62 (27%)
CARD10	NP_055365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		7/18 (39%)
		CARD_CARD10_CARMA3	27..112	CDD:260069	20/104 (19%)
		Tmemb_cc2	<112..245	CDD:287269	28/182 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..276		6/28 (21%)
		ThylakoidFormat	<282..395	CDD:299915	20/114 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..553		5/71 (7%)
		SH3	705..770	CDD:302595	18/68 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910