DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and MAGI3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	1232	Identity:	247/1232 - (20%)
Similarity:	418/1232 - (33%)	Gaps:	373/1232 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTDSEREKSSDPNEGLLSSDDKTFHDDDEPAEDSSPADDEEEPEEEECLLPQKKAQIRCDQDQPP 68
            |.:|:|::::..::             .|..:.|.|  :|||.|::|.:.....|:.|....:
Human   215 DAESQRKRTTSVSK-------------MERMDSSLP--EEEEDEDKEAINGSGNAENRERHSE-- 262

  Fly    69 LVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMD------GDSQLE-----------------VM 110
                   |::.::.....:.||        |.||      .|..||                 .:
Human   263 -------SSDWMKTVPSYNQTN--------SSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFI 312

  Fly   111 EHQMETVTEPDP---EPPKCPTSLRDSVRESVECFYSAQDL--LEYG-----HMLSSTSMVR--- 162
            :|..:|.|..||   :..|.|....|.     |..|..:.:  .:||     |:...|....
Human   313 DHNTKTTTWLDPRLCKKAKAPEDCEDG-----ELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVE 372

  Fly   163 ----------------TPDVESGYFEKSESDAS------------------------RDEW---- 183
                            .||:|..:|.:..|...                        .||:
Human   373 EAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVK 437

  Fly   184 ----EGPSSSSSGAARCRLLSGISGLSVSSSSRHSA----------EGLRMELSRFRTMIETLER 234
                :||::.....|...::..|:|..|...:....          :.:.:.|.|...:.:..|.
Human   438 NVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSED 502

  Fly   235 ESLEKSQSELQLKAKSKAKPKP-------KQRSHVQDAAGESGSEQGSERGFWSTIFGQAGLAIS 292
            ..::...:...:..:|..|.:.       |..:.|.:..|:||          .|:.|......|
Human   503 PVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSG----------HTLTGDGLNGPS 557

  Fly   293 QDEEERIADIQKAHRALELLEDYHARLSEPQDRALRIAI----ERVIRIFKSRLFQALLD---IQ 350
            ...|:|::.........||:.  ...:..|:.....||.    ::|..|..|:..|.|..   |:
Human   558 DASEQRVSMASSGSSQPELVT--IPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIK 620

  Fly   351 EFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIE----SDTENAKEPTVEQQQ 411
            |.|.       :::|..|  .||:.   |...|....||...:.:.    |.|:.||..|   .:
Human   621 EIYH-------QNVQNLT--HLQVV---EVLKQFPVGADVPLLILRGGPPSPTKTAKMKT---DK 670

  Fly   412 KQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSW-----LYE---------DIQLERGNS 462
            |:......:...|..| |.....|..||||..::..:.:     |||         |:.|.:..|
Human   671 KENAGSLEAINEPIPQ-PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES 734

  Fly   463 GLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALK 527
            |.||.:.||.     |.|.||||..:|..|||..||||...|.::.::.:.|....|...:|.:.
Human   735 GFGFRVLGGD-----GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMT 794

  Fly   528 KA---GNVVKLHVKRK-------------RGTATTPAAGSAAGDARDSAASGPKVIEIDLV---K 573
            .|   |:|: |.|:||             :...:|.........|...|...|:. ..|:|   |
Human   795 TAARNGHVL-LTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQE-PYDVVLQRK 857

  Fly   574 GGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHE 638
            ..:|.||.|... .|:..||.....:.::::|..|...|:|.:||.:.||  ||  :::..::|:
Human   858 ENEGFGFVILTS-KNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV--NG--QSIVELSHD 917

  Fly   639 LAVATLKSITDKVTL-IIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHAT 702
            ..|..:|.....||| :|.:.:|      .|...|.:|.:            ||.:..|:
Human   918 NIVQLIKDAGVTVTLTVIAEEEH------HGPPSGTNSAR------------QSPALQHR----- 959

  Fly   703 PMVNSQSTE-PGSRYASTNVLAA-VPPGTPRAVSTEDITREPRT------------------ITI 747
            ||..||:.. ||.|.|....:.. |......:.|......:|.|                  :.:
Human   960 PMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL 1024

  Fly   748 QKGPQGLGFNIVGGED-GQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALK 811
            ::||:|.||::.||:: ..|:::..:...|||.....:..|||::.:|.......||..|.:.::
Human  1025 ERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089

  Fly   812 TSGGVVTLLAQYRP-----------------------------------------------EEYN 829
            ..|..|.||  .||                                               ||..
Human  1090 AGGNKVLLL--LRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESL 1152

  Fly   830 RFE--ARIQELK-----QQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHG 887
            |.:  .:.:|||     :::.|.....     ..:.:||..:.:...||           |..||
Human  1153 RVQICEKAEELKDIVPEKKSTLNENQP-----EIKHQSLLQKNVSKRDP-----------PSSHG 1201

  Fly   888 -----DILHVTNASDDEWWQA--RRVLGDNEDEQIGIVPSKRRWERKMRARDRSV---------- 935
                 ::|.|.|.........  ::....:.:|.:..:||..:...|.|.||:|:
Human  1202 HSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSKGENKSC 1266

  Fly   936 --------------KFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQE 983
                          |.:|.:|:..   ||..::..|.......|....|||......||:.|
Human  1267 QVSTRAGSGQDQCRKSRGRSASPK---KQQKIEGSKAPSNAEAKLLEGKSRRIAGYTGSNAE 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	13/62 (21%)
		PDZ	454..540	CDD:214570	31/88 (35%)
		PDZ_signaling	566..655	CDD:238492	26/92 (28%)
		PDZ_signaling	742..820	CDD:238492	22/96 (23%)
		SH3_DLG-like	862..922	CDD:212795	11/66 (17%)
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273		14/81 (17%)
		WW	294..326	CDD:197736	5/31 (16%)
		WW	342..372	CDD:238122	5/29 (17%)
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492		9/81 (11%)
		PDZ	413..493	CDD:214570	9/79 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570		8/37 (22%)
		PDZ	575..656	CDD:214570	21/94 (22%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		31/87 (36%)
		PDZ_signaling	726..807	CDD:238492	30/86 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		2/21 (10%)
		PDZ_signaling	849..935	CDD:238492	26/90 (29%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		27/91 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		14/59 (24%)
		PDZ_signaling	1022..1100	CDD:238492	22/79 (28%)
		Red1	<1132..1461	CDD:311769	38/213 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481		32/175 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810