DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Dlg1

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	XP_038943929.1	Gene:	Dlg1 / 25252	RGDID:	2505	Length:	939	Species:	Rattus norvegicus

Alignment Length:	813	Identity:	354/813 - (43%)
Similarity:	475/813 - (58%)	Gaps:	150/813 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 QKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSI-QQ 366
            |...|||.|||:|.::||:.:||.||.:|||||.||:|.|||||:|||||||:||||:.|.: ..
  Rat     6 QDTQRALHLLEEYRSKLSQTEDRQLRSSIERVISIFQSNLFQALIDIQEFYEVTLLDNPKCVDHS 70

  Fly   367 KTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSR-SPQQQN-- 428
            |..|.:|....||....:.....::.:      .....|.||:.:.|.:....|.| |||..|
  Rat    71 KQCEPVQPGNPWESGSLSSAAVTSESL------PGGLSPPVEKYRYQDEEVLPSERISPQVPNEV 129

  Fly   429 --PQQQQGS-KSRSGSQTVNG-------------------------------------------- 446
              |:....| ||.|..:.|:|
  Rat   130 LGPELVHVSEKSLSEIENVHGFVSHSHISPIKPTEAVPPSSPIVPVTPALPVPAESPVVLPSTPQ 194

  Fly   447 ----------------------DDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLI 489
                                  |..:.||:|.||||||||||||||||||||||.|:||:|||:|
  Rat   195 ANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKII 259

  Fly   490 SGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAG 554
            :|||||.||||.:||.|:.||:..|.||.|:.||:|||:||::|:|:|||::     ||:
  Rat   260 TGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRK-----PAS----- 314

  Fly   555 DARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDK 619
                     .|::||.|:||.||||||||||:|||||||||.|||||:::||||..||:|.||||
  Rat   315 ---------EKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370

  Fly   620 LIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQS 684
            |:||    :...||.||||.||..||:.:|.|.|.:.|...:.          ::.|    .:..
  Rat   371 LLAV----NSVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMY----------INDG----YAPP 417

  Fly   685 QLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQK 749
            .:..|.|||   ...|.:|     |:..|...||.   |...|.:...:..::||||||.:.:.:
  Rat   418 DITNSSSQS---VDNHVSP-----SSYLGQTPASP---ARYSPISKAVLGDDEITREPRKVVLHR 471

  Fly   750 GPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSG 814
            |..||||||||||||:||::|||||||||||..||::||:::|||:|:|..|:||:||.|||.:|
  Rat   472 GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

  Fly   815 GVVTLLAQYRPEEYNRFEARIQELKQQA--ALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGL 877
            ..||::||||||||:||||:|.:|::|.  :..:.|||: |||:||||||||||||||..:|.||
  Rat   537 QAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGS-LRTSQKRSLYVRALFDYDKTKDSGL 600

  Fly   878 PSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAA 942
            ||:||.||.||||||.|||||||||||:|..|.|.:::|::|||||.|:|.|||.::|||.....
  Rat   601 PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR 665

  Fly   943 ANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGGEIIYRVEL 1007
            .:..   ||..|::|||. |||||||.|::|:..::.||.:..:      .:||...|..|.:.:
  Rat   666 GDKG---QSFNDKRKKNL-FSRKFPFYKNKDQSEQETSDADQHV------TSNASDSESSYLILI 720

  Fly  1008 PD--------MEQITLIY--LENNDADYRKSSI 1030
            .|        .|:..|.|  :...:.:|.:..|
  Rat   721 TDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVI 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	36/55 (65%)
		PDZ	454..540	CDD:214570	59/85 (69%)
		PDZ_signaling	566..655	CDD:238492	56/88 (64%)
		PDZ_signaling	742..820	CDD:238492	48/77 (62%)
		SH3_DLG-like	862..922	CDD:212795	41/59 (69%)
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492	57/83 (69%)
		PDZ_signaling	317..403	CDD:238492	56/89 (63%)
		PDZ_assoc	404..465	CDD:402299	18/85 (21%)
		PDZ	463..547	CDD:214570	52/83 (63%)
		SH3_DLG1	582..648	CDD:212964	47/65 (72%)
		Guanylate_kin	748..926	CDD:395500	2/6 (33%)
		L27_1	2..62	CDD:401120	36/55 (65%)
		MAGUK_N_PEST	106..223	CDD:402306	16/116 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339821
Domainoid	1	1.000	311	1.000	Domainoid score	I1273
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20869
Inparanoid	1	1.050	882	1.000	Inparanoid score	I381
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm44403
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810