DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dlg1 and Magi3

DIOPT Version :9

Sequence 1:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	1214	Identity:	251/1214 - (20%)
Similarity:	417/1214 - (34%)	Gaps:	411/1214 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EREKSSDPNEGLLSSD--DKTFHDDDEPAEDSSP----------ADDEEEPEEE----------- 49
            |:.|:.:.:..||.|.  |..|:...:|..:.||          .|:|.:.|.:
  Rat   168 EQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKME 232

  Fly    50 --ECLLPQKKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDD-----------TNPVAVAAKASD- 100
              :..||::      ::|:....|....|.|..|:..|..|           ||      ::.|
  Rat   233 RMDSSLPEE------EEDEDKEAVNGSGSMETREMHSESSDCWMKTVPSYNQTN------RSMDF 285

  Fly   101 ---MDGDSQLE-----------------VMEHQMETVTEPDP---EPPKCPTSLRDSVRESVECF 142
               |..|..||                 .::|..:|.|..||   :..|.|....|.     |..
  Rat   286 RNYMMRDENLEPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDG-----ELP 345

  Fly   143 YSAQDL--LEYG-----HMLSSTSMVRTPDVESGYFEKSESDASRDEWEGPSSSSSG------AA 194
            |..:.:  .:||     |:...|.           ||....:|.|.:..|.:.:.|.      |.
  Rat   346 YGWEKIEDPQYGTYYVDHLNQKTQ-----------FENPVEEAKRKKQIGQAETHSAKTDVERAH 399

  Fly   195 RCRLLSGISGLSVSSSSRHSAEGLRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQR 259
            ..|..|.:.|:.|.:|.:.|..|...      |:|      ..::....||:|...|..|.
  Rat   400 FTRDPSQLKGVLVRASLKKSTMGFGF------TII------GGDRPDEFLQVKNVLKDGPA---- 448

  Fly   260 SHVQDAAGESGSEQGSERGFWSTIFGQA-----------------------GLAISQDEEERIAD 301
              .||.....|.......|  :.:.|..                       |.|:..|.|:.:.|
  Rat   449 --AQDGKMAPGDVIVDING--NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYALPDDSEDPVVD 509

  Fly   302 IQKAHRAL-------------------------------ELLEDYHARLSEPQD----------- 324
            |..|...:                               :||...|  |:.|.|
  Rat   510 IVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSGKLLSSDH--LNGPSDSNEQRASLASS 572

  Fly   325 ----------------RALRIAI------ERVIRIFKSRLFQALLD---IQEFYELTLLDDSKSI 364
                            :....||      ::|..|..|:..|.|..   |:|.|.       :::
  Rat   573 GSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYH-------QNV 630

  Fly   365 QQKTAETLQIATKWEKDGQAVKI--------ADNQRMRIESDT-------ENAKEPTVEQQQKQQ 414
            |..|...:....|....|..|.:        :..:..::::||       |...|||
  Rat   631 QNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKETSGSLETINEPT-------- 687

  Fly   415 QAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSW-----LYE---------DIQLERGNSGLG 465
                     ||   |.....|..||||..::..:.:     |||         |:.|.:..||.|
  Rat   688 ---------PQ---PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFG 740

  Fly   466 FSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKA- 529
            |.:.||.     |.|.||||..:|..|||..||||...|.::.::.:.|....|...:|.:..|
  Rat   741 FRVLGGD-----GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 800

  Fly   530 --GNVV-----KLHVKRKRGTATTPAAGSAAGDARDS-----AASGPKVIEIDLV---KGGKGLG 579
              |:|:     |:....|:....:|.|.|.:|..|.:     ..|.|:. ..|::   |..:|.|
  Rat   801 RNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELPTRSAPQE-SYDVILQRKENEGFG 864

  Fly   580 FSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATL 644
            |.|... .::..||.....:.:::||..|...|||.:||.:.||  ||  :::.:::|:..|..:
  Rat   865 FVILTS-KSKPPPGVIPHKIGRVIDGSPADRCGRLKVGDHISAV--NG--QSIVDLSHDNIVQLI 924

  Fly   645 KSITDKVTL-IIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQ 708
            |.....||| ::.:.:|      .|...|.:|.:            ||.:..|:     ||..:|
  Rat   925 KDAGVTVTLTVVAEEEH------HGPPSGTNSAR------------QSPALQHR-----PMGQAQ 966

  Fly   709 STE-PGSRYA-----STNVLAA-----------VPPGTPRAVSTEDITREPRT-----ITIQKGP 751
            :|. ||.|.|     ..:|.::           ..|.|  ||.:...:|..::     :.:::||
  Rat   967 ATHIPGDRTALEGEVGKDVCSSYRHSWSDHKHLAQPDT--AVISVVGSRHSQSLGCYPVELERGP 1029

  Fly   752 QGLGFNIVGGED-GQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGG 815
            :|.||::.||:: ..|:::..:...|||.....:..|||::.:|.......||..|.:.::..|.
  Rat  1030 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGN 1094

  Fly   816 VVTLLAQ--------------YRPEEYN-----------------RFE-----------ARIQ-- 836
            .|.||.:              |.|...|                 .||           .|:|
  Rat  1095 KVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPPPLPSSHSAATFEESHVPVTEDSLIRVQTC 1159

  Fly   837 ----ELK-----QQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLP-FKHGDILH 891
                |||     :::.|.........::.||.      :...||:|..|...:.|| .::|....
  Rat  1160 EKAEELKDTVQEKKSTLNGSQPEMKYQSVQKN------VSKKDPSRSHGHGDKNLPKGENGVTRR 1218

  Fly   892 VTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSV 935
            ..:||      .::.:..:.:|.:..:|...|.:.|.::||||:
  Rat  1219 GRSAS------PKKSVNRHSEEHLEKIPRPLRSDPKGKSRDRSL 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	17/122 (14%)
		PDZ	454..540	CDD:214570	30/93 (32%)
		PDZ_signaling	566..655	CDD:238492	26/92 (28%)
		PDZ_signaling	742..820	CDD:238492	20/83 (24%)
		SH3_DLG-like	862..922	CDD:212795	11/60 (18%)
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:418433	8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		16/87 (18%)
		HUL4	<211..>373	CDD:227354	35/189 (19%)
		WW	299..329	CDD:238122	5/29 (17%)
		WW	345..375	CDD:238122	7/40 (18%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		15/101 (15%)
		PDZ	416..496	CDD:214570	14/99 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575		6/26 (23%)
		PDZ	578..659	CDD:214570	15/87 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700		10/54 (19%)
		PDZ	729..812	CDD:214570	29/87 (33%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		29/86 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847		7/28 (25%)
		PDZ_signaling	851..936	CDD:238492	26/89 (29%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		26/91 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		14/59 (24%)
		PDZ_signaling	1023..1101	CDD:238492	22/77 (29%)
		PTZ00112	1115..>1405	CDD:240274	30/154 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470		20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900